The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
A
facile,
cost-effective,
and
sustainable
synthesis
of
substituted
triazines
from
primary
alcohols
by
newly
synthesized
nickel
pincer-type
complexes
(1–3)
has
been
described.
Herein,
we
report
the
a
set
three
well-defined
Ni(II)
O^N^O
complexes,
structurally
characterized
analytical,
spectral,
X-ray
diffraction
techniques.
Further,
are
explored
as
efficient
catalysts
(4
mol
%)
for
construction
2,4,6-substituted
1,3,5-triazines
readily
available
via
an
acceptorless
dehydrogenative
coupling
(ADC)
strategy.
wide
range
triazine
derivatives
(33
examples)
benzamidine/guanidine
hydrochloride
with
maximum
isolated
yield
92%
under
mild
conditions,
eco-friendly
H2O
H2
gas
only
byproducts.
plausible
mechanism
proposed
based
on
sequence
control
experiments.
Interestingly,
short
antiulcer
drug
irsogladine
large-scale
2,4-diphenyl-6-(p-tolyl)-1,3,5-triazine
highlight
convenience
current
methodology.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(33), P. 23338 - 23347
Published: Aug. 6, 2024
A
single-atom
iron
catalyst
was
found
to
exhibit
exceptional
reactivity
in
acceptorless
dehydrogenative
coupling
for
quinoline
synthesis,
outperforming
known
homogeneous
and
nanocatalyst
systems.
Detailed
characterizations,
including
aberration-corrected
HAADF-STEM,
XANES,
EXAFS,
jointly
confirmed
the
presence
of
atomically
dispersed
centers.
Various
functionalized
quinolines
were
efficiently
synthesized
from
different
amino
alcohols
a
range
ketones
or
alcohols.
The
achieved
turnover
number
(TON)
up
10
Science,
Journal Year:
2025,
Volume and Issue:
387(6738), P. 1108 - 1114
Published: March 6, 2025
The
synthesis
of
nitrogen-containing
molecules
through
carbon-nitrogen
(C-N)
bond
formation
is
critical
for
the
discovery
and
preparation
medicines,
agrochemicals,
materials.
Here,
we
report
direct
insertion
a
nitrogen
atom
into
unactivated
carbon-carbon
double
bonds
to
access
aza-allenium
intermediates,
which
can
be
converted
either
nitriles
or
amidine
products,
depending
on
initial
alkene
substitution
pattern.
This
operationally
simple
highly
functionally
compatible
reaction
works
wide
range
alkenes.
PIFA,
commercially
available
inexpensive
hypervalent
iodine
reagent,
key
this
reactivity.
Our
mechanistic
proposal
supported
by
chemical
trapping
experiments,
concomitantly
demonstrate
utility
our
method
valuable
N-heterocycles.
Additionally,
used
as
general
strategy
synthesizing
amides
amines,
well
15N-labeled
molecules.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(46), P. 32098 - 32104
Published: Nov. 11, 2024
Aromatic
N-heterocycles,
such
as
pyrroles
and
pyridines,
are
important
natural
products
bulk
fine
chemicals
with
numerous
applications
active
ingredients
of
pharmaceuticals
agrochemicals,
catalysts,
in
materials
sciences.
We
report
here
a
catalytic
version
the
Knorr
pyrrole
synthesis
which
simple
diversely
available
starting
materials,
1,2-amino
alcohols
or
1,3-amino
keto
esters,
undergo
dehydrogenative
coupling
to
form
respectively.
Our
reaction
forms
hydrogen
collectible
(and
usable)
byproduct
is
mediated
by
well-defined
Mn
catalyst.
The
highly
functionalized
heterocycles
was
demonstrated,
35
compounds,
not
yet
reported
literature,
were
introduced.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
A
highly
efficient
copper-catalyzed
oxidative
dehydrogenation
of
primary
amines
to
access
nitriles
has
been
developed.
We
found
that
DMAP
was
an
ligand
for
oxidation
and
molecular
oxygen
a
green
oxidizing
agent.
This
reaction
exhibited
excellent
functional
group
compatibility
broad
substrate
scope.
Various
benzylic,
allylic,
aliphatic
were
selectively
effectively
oxidized
the
corresponding
in
high
yields
(up
100%).
The
not
only
accelerated
rate
but
also
enhanced
stability
catalyst.
practicality
illustrated
on
gram
scale,
even
at
lower
catalyst
loading
and/or
under
bubble
air
conditions.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(13)
Published: April 1, 2025
Abstract
Considering
the
slow
kinetics
of
oxygen
evolution
reaction
(OER)
and
need
for
high
potential,
organic
electro
oxidation,
which
is
more
prone
to
occur
at
low
adopted
replace
OER
process.
The
research
method
combined
with
hydrogen
(HER)
has
gradually
become
mainstream
direction
synergistic
production
value‐added
products.
In
this
work,
NiFeB
hydroxide
(NiFeB(OH))
nanosheet
was
prepared.
Benefited
from
incorporation
electron‐deficient
boron
(B),
NiFeB(OH)
catalyst
exhibited
excellent
catalytic
activity
electrooxidation
benzylamine
(BA),
benzonitrile
(BN)
being
successfully
fabricated.
experiment
further
proves
that
conversion
BA
BN
not
only
selectivity
(100%)
Faraday
efficiency
(94.15%),
but
also
stability,
can
achieve
long‐term
operation.
studied
in
work
provides
new
ideas
methods
efficient
benzonitrile,
an
intermediate.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Ruthenium
complex
Ru(p-cymene)@Aza-COF
was
synthesized
by
the
immobilization
of
[Ru(p-cymene)Cl][Cl]
on
a
2D
Aza-COF.
Then,
this
utilized
as
an
auto-tandem
catalyst
for
preparation
quinazolinones
from
allylic
alcohols
and
o-aminobenzamides
via
redox
isomerization/acceptorless
dehydrogenative
coupling.
More
importantly,
its
catalytic
activity
is
well
maintained
during
six
runs.
