ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 7, 2025
Dual-atom
nanozymes
(DAzymes)
have
garnered
considerable
attention
as
catalysts
for
reactive
oxygen
species
(ROS)-based
therapies,
effectively
leveraging
ROS
generation
within
the
tumor
microenvironment
(TME).
Herein,
we
introduce
FeMn-NCe
DAzymes,
which
are
meticulously
engineered
enhanced
peroxidase
(POD)-mimetic
activity
and
potent
radiosensitization
to
advance
radioimmunotherapy.
Density
functional
theory
(DFT)
calculations
reveal
that
DAzymes
lower
energy
barrier
increase
substrate
affinity,
enabling
highly
efficient
catalytic
performance.
Within
TME,
these
efficiently
convert
overexpressed
hydrogen
peroxide
(H2O2)
into
hydroxyl
radicals
(•OH),
potentially
activating
cGAS-STING
immune
pathway.
This
POD-mimetic
catalysis
is
further
accelerated
under
X-ray
irradiation,
significantly
enhancing
radiosensitization.
Additionally,
a
uniform
coating
of
ultrasmall
gold
nanoparticles
on
enhances
absorption
cancer
cells.
The
incorporation
STING
agonist
diABZI
onto
induces
long-term
antitumor
immunity,
reprograms
immunosuppressive
suppresses
growth
metastasis
following
single
low-dose
treatment.
work
highlights
valuable
strategy
designing
radiodynamic
immunotherapy.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(33), P. 13663 - 13671
Published: Aug. 10, 2024
Rapid
and
accurate
detection
of
human
epidermal
growth
factor
receptor
2
(HER2)
is
crucial
for
the
early
diagnosis
prognosis
breast
cancer.
In
this
study,
we
reported
an
iron-manganese
ion
N-doped
carbon
single-atom
catalyst
(FeMn-NC
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 19, 2024
Abstract
The
global
crisis
of
bacterial
infections
is
exacerbated
by
the
escalating
threat
microbial
antibiotic
resistance.
Nanozymes
promise
to
provide
ingenious
solutions.
Here,
we
reported
a
homogeneous
catalytic
structure
Pt
nanoclusters
with
finely
tuned
metal–organic
framework
(ZIF‐8)
channel
structures
for
treatment
infected
wounds.
Catalytic
site
normalization
showed
that
active
aggregates
fine‐tuned
pore
modifications
had
capacity
14.903×10
5
min
−1
,
which
was
18.7
times
higher
than
particles
in
monodisperse
state
ZIF‐8
(0.793×10
).
In
situ
tests
revealed
change
from
homocleavage
heterocleavage
hydrogen
peroxide
at
interface
nanozyme
one
key
reasons
improvement
activity.
Density‐functional
theory
and
kinetic
simulations
reaction
jointly
determine
role
center
substrate
together.
Metabolomics
analysis
developed
nanozyme,
working
conjunction
reactive
oxygen
species,
could
effectively
block
energy
metabolic
pathways
within
bacteria,
leading
spontaneous
apoptosis
rupture.
This
pioneering
study
elucidates
new
ideas
regulation
artificial
enzyme
activity
provides
perspectives
development
efficient
substitutes.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Photoelectrochemical
(PEC)
sensing
mechanisms
based
on
enzyme-catalyzed
strategies
primarily
achieve
the
quantitative
analysis
of
biomolecules
through
enhancement
or
attenuation
photocurrent
signals.
However,
there
are
still
no
reports
that
delve
into
principles
signaling
conversion
in
reaction
between
photoactive
materials
and
biomolecules.
In
this
work,
we
demonstrated
indium
oxysulfide
InOS-0.5
heterojunction
has
excellent
peroxidase
activity
to
catalyze
H
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
Abstract
Heterojunctions
are
sustainable
solutions
for
the
photocatalytic
CO
2
reduction
reaction
(CO
RR)
by
regulating
charge
separation
behavior
at
interface.
However,
their
efficiency
and
product
selectivity
severely
hindered
inflexible
weak
built‐in
electric
field
electronic
structure
of
two
phases.
Herein,
ferroelectric‐based
heterojunctions
between
polarized
bismuth
ferrite
(BFO(P))
CdS
constructed
to
enhance
interfacial
interactions
catalytic
activity.
The
intrinsic
polarization
depending
on
ferroelectric
state
causes
significant
electrostatic
potential
difference
energy‐band
bending.
This
helps
overcome
unsatisfactory
redox
that
differs
from
classical
mechanism,
synergy
heterostructure
facilitates
effective
transfer
photogenerated
charges
with
an
extended
lifetime
(>20
ns)
significantly
enhanced
photovoltage
(1002
times
BFO).
optimized
carrier
dynamics
allow
heterojunction
achieve
a
much
higher
yield
compared
state‐of‐the‐art
photocatalysts,
85.46
23.47
than
those
pristine
BFO,
respectively.
Moreover,
it
maintains
impressive
100%
together
excellent
repeatability
cycling.
work
not
only
sheds
light
how
strong
inherent
polarity
promotes
performance
photocatalysts
but
also
provides
new
insights
designing
efficient
RR.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
64(1)
Published: Aug. 22, 2024
Single-atom
nanozymes
(SAzymes)
with
ultrahigh
atom
utilization
efficiency
have
been
extensively
applied
in
reactive
oxygen
species
(ROS)-mediated
cancer
therapy.
However,
the
high
energy
barriers
of
reaction
intermediates
on
single-atom
sites
and
overexpressed
antioxidants
tumor
microenvironment
restrict
amplification
oxidative
stress,
resulting
unsatisfactory
therapeutic
efficacy.
Herein,
we
report
a
multi-enzyme
mimetic
MoCu
dual-atom
nanozyme
(MoCu
DAzyme)
various
catalytic
active
sites,
which
exhibits
peroxidase,
oxidase,
glutathione
(GSH)
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
mimicking
activities.
Compared
Mo
SAzyme,
introduction
Cu
atoms,
formation
synergetic
effects
among
enhance
substrate
adsorption
reduce
barrier,
thereby
endowing
DAzyme
stronger
Benefiting
from
above
enzyme-like
activities,
can
not
only
generate
multiple
ROS,
but
also
deplete
GSH
block
its
regeneration
to
trigger
cascade
stress.
Additionally,
strong
optical
absorption
near-infrared
II
bio-window
endows
remarkable
photothermal
conversion
performance.
Consequently,
achieves
high-efficiency
synergistic
treatment
incorporating
collaborative
therapy
This
work
will
advance
applications
DAzymes
provide
valuable
insights
for
nanocatalytic
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 2, 2024
Abstract
Given
the
pronounced
dissolution
of
electrocatalysts
in
acidic
environments,
quest
for
effective
oxygen
evolution
reaction
(OER)
suitable
proton
exchange
membrane
(PEM)
water
electrolyzers
persists
as
a
formidable
challenge.
In
this
investigation,
catalysts
are
synthesized
by
creating
vacancies
within
various
metal
oxides
(Nb
2
O
5‐x
,
Ta
ZrO
2‐x
TiO
)
through
plasma‐assisted
method,
thereby
facilitating
immobilization
IrO
onto
these
defect‐rich
surfaces.
The
findings
unveil
that
/Nb
manifests
reduced
overpotentials
during
OER,
achieving
an
overpotential
down
to
225
mV@10
mA
cm
−2
coupled
with
outstanding
durability
at
multicurrent
densities
exceeding
200
h,
attributed
strong
oxide‐support
interaction
(SOSI)
between
catalyst
and
Nb
substrate.
Density
functional
theory
(DFT)
computations
uncover
intensified
binding
affinities
thus
modulating
central
energy
levels
Ir's
d
orbitals
toward
favorable
OER
conditions,
consequently
bolstering
electrocatalytic
activity
stability
composite
catalyst.
Furthermore,
employing
PEM
electrolyzer
anode
enables
consistent
operation
1000
Ir
content
only
0.2852
mg
consumption
4.34
kWh
Nm
−3
H
.
This
achievement
substantially
lowers
cost
hydrogen
production
US$
0.96
per
kilogram,
underscoring
its
potential
practical
applications.
ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
6(6), P. 2487 - 2496
Published: May 23, 2024
Nanozyme
hybrids
with
photothermally
mediated
catalytic
activity
have
received
increasing
attention
in
addressing
the
challenges
of
public
health
events
caused
by
bacterial
infections.
However,
designing
photothermal
nanozyme
efficient
synergistic
antibacterial
properties
remains
a
challenge
but
is
desirable.
Herein,
prepared
CuxO@PDA
(CP)
showed
excellent
conversion
efficiency
39.81%.
More
interestingly,
CP
also
possesses
peroxidase-like
activity,
which
could
convert
H2O2
to
•OH,
and
capability
was
improved
under
NIR
irradiation.
The
effect
between
makes
proposed
therapy
able
kill
99.74%
Staphylococcus
aureus
(S.
aureus)
99.82%
Escherichia
coli
(E.
coli).
In
vivo
experiments
further
that
ability
be
well
applied
wound
infection
treatment.
Overall,
our
work
provides
insight
into
design
high-efficacy
photothermal-mediated
compounds
for
broad-spectrum
applications.
