Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
An electrochemical sulfenylation of unprotected N -heterocycles with a wide range commercially available arylsulfonyl chlorides was developed.
Language: Английский
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Utilizing electrons directly offers significant potential for advancing organic synthesis by facilitating novel reactivity and enhancing selectivity under mild conditions. As a result, an increasing number of chemists are exploring electrosynthesis. However, the efficacy electrochemical transformations depends critically on design cell. Batch cells often suffer from limitations such as large inter-electrode distances poor mass transfer, making flow promising alternative. Implementing cells, however, requires foundational understanding microreactor technology. In this review, we briefly outline applications electrosynthesis before providing comprehensive examination existing reactor technologies. Our goal is to equip with insights needed tailor their meet specific requirements effectively. We also highlight application designs in scaling up processes integrating high-throughput experimentation automation. These advancements not only enhance synthetic community but hold promise both academia industry.
Language: Английский
Citations
9
Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Comprehensive Summary The N–H methylsulfoxidation of sulfoximines using DMSO as a methylsulfinyl source, induced by electrochemistry, has been developed. This method is the first example an electrochemical reaction in which serves source. Unlike previous reactions involving substrate, exclusively proceed via radical mechanisms, this follows S‐cation pathway. A wide range N ‐methylsulfinyl were successfully obtained.
Language: Английский
Citations
0
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(9), P. 7524 - 7532
Published: Feb. 19, 2025
Despite a few successful examples, controlling the enantioselectivity in asymmetric synthesis of non-C2-symmetric biaryldiols has long been challenging. To address issues and regioselectivity, we introduced novel organoelectrocatalytic strategy enabling aryl-aryl dehydrogenative cross-coupling reactions. Using this approach, valuable were obtained up to 95% yields 97% enantiomeric excesses (ees), these compounds could be further applied as versatile ligands Detailed mechanistic studies supported sequential diradical followed by central-to-axial chirality conversion pathway.
Language: Английский
Citations
0
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 10, 2025
Abstract Deuterium labeling has found extensive applications across various research fields, including organic synthesis, drug design, and molecular imaging. Electrocatalytic semi-hydrogenation of alkynes offers a viable route for the synthesis Z -alkenes, yet it falls short in achieving semi-deuteration these compounds. In this study, we report an electrochemical cobalt-catalyzed transfer deuteration reaction that proficiently accomplishes alkynes, yielding -configuration deuterated alkene products. This utilizes cost-effective cobalt salts as catalysts employs D 2 O AcOD (acetic acid- d ) economical efficient deuterium sources, underscoring its practicality feasibility. The demonstrates broad alkyne substrate scope, high efficiency, good functional group compatibility, excellent -selectivity, remarkable degree rate.
Language: Английский
Citations
0
Small Methods, Journal Year: 2025, Volume and Issue: unknown
Published: April 21, 2025
Abstract Continuous‐flow nanoconfined catalysis is crucial for rapid and efficient water purification but challenging traditional reactors. Supramolecular metal–organic membranes, with their intrinsically rich metal nodes, present promising opportunities heterogeneous nano‐catalysis. However, achieving a uniform distribution stabilization of exposed active sites remains challenge. Here, phosphotungstic acid (H 3 PW 12 O 40 : ) modulated interfacial coordination strategy introduced to engineer thin palladium‐1,3,5‐triformylphloroglucinol (Pd‐Tp) nanofilm. The strong electrostatic‐dominated interaction between the fourfold hollow site Pd II enables in situ confined reduction, facilitating enhanced loading cluster‐shaped Pd‐PW nanoparticles within layer. hydrophilic Tp leads competition PdCl 4 2‐ during film formation, giving rise thinner, more hydrophilic, loose‐structured membranes. Importantly, PCM/NaBH system exhibits superior reducibility electron transfer capacity, enabling degradation range organic contaminants, attributed robust metal‐support interactions. PCM achieves rate constant target pollutant 4‐nitrophenol (97.8 ms −1 ), which 175 times faster than that control HCM (0.56 ). This study highlights role microstructure modulation membrane synergistic catalysis.
Language: Английский
Citations
0
Green Chemistry, Journal Year: 2024, Volume and Issue: 26(23), P. 11524 - 11530
Published: Jan. 1, 2024
An exogenous electrolyte- and base-free electrochemical cobalt-catalysed atroposelective C–H annulation has been established to construct N–N axially chiral isoquinolinones in excellent enantioselectivities good yields.
Language: Английский
Citations
3
Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(28), P. 5724 - 5728
Published: Jan. 1, 2024
Herein, a novel electroreductive carboxylation of benzylphosphine salts with CO 2 through cleavage the C(sp 3 )-P bond was reported under conditions without redox reagents and noble metal catalysts.
Language: Английский
Citations
2
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(74), P. 10120 - 10123
Published: Jan. 1, 2024
Electroorganic synthesis has become an exciting tool for the asymmetric conversion of pro-chiral compounds. Herein, we introduced a wireless methodology based on bipolar electrochemistry in synergy with enantioselective capabilities inherently chiral oligomers to induce umpolung chirality transfer. This was exemplified by electro-conversion racemic mixture lansoprazole
Language: Английский
Citations
2
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)
Published: Aug. 30, 2024
The control of enantioselectivity in radical cation reactions presents long-standing challenges, despite a few successful examples. We introduce novel strategy asymmetric counteranion-directed electrocatalysis to address chemistry. This concept has been successfully demonstrated two reactions: an dehydrogenative indole-phenol [3+2] coupling and atroposelective C-H/N-H coupling. These have enabled the synthesis benzofuroindolines C-N axially chiral indoles with high yields excellent enantiomeric excesses. Detailed mechanistic studies confirmed radical-radical mechanism. Moreover, density functional theory (DFT) calculations supported indole as pivotal intermediate, rather than neutral indolyl radical, shedding new light on underlying processes driving these reactions.
Language: Английский
Citations
2
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(59), P. 7614 - 7617
Published: Jan. 1, 2024
A mild and efficient electrochemical method for radical addition, cyclization, migration reaction was described in this work. difluoromethyl produced by anodizing CF
Language: Английский
Citations
1