The Innovation Materials, Journal Year: 2024, Volume and Issue: unknown, P. 100110 - 100110
Published: Dec. 16, 2024
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 19, 2024
Abstract Molecular photoswitches can undergo isomerization under light exposure, making them uniquely attractive for high spatiotemporal resolution remote control of biological functions. Visible and near‐infrared (NIR) light, with their low energy consumption, safety, strong tissue penetration, are particularly suitable applications. Therefore, developing visible‐ NIR light‐driven molecular use is great significance. This review introduces the most common presents state‐of‐art applications in bioimaging, biosensing, drug delivery, photocontrolled cancer phototherapy, photopharmacology. The opportunities challenges future development outlined.
Language: Английский
Citations
4
Small, Journal Year: 2025, Volume and Issue: 21(11)
Published: Feb. 3, 2025
Abstract A red‐light switchable fast, near‐quantitative two‐way photoswitching of an azoheteroarene, arylazo‐ N ‐phenyl‐3,5‐diphenyl pyrazole ( AAP1 ), with a high thermal half‐life the cis ‐isomer is reported here. The photochromic molecule switches in solution phase and even thin films. design incorporates structural features that enable → trans reversal under red light quantitatively. Solid‐state pristine films has been demonstrated using . Various photo patterns on paper as ink are generated their switching displaying change color investigated. Single‐crystal XRD structures well as, more exciting rarely observed form, obtained. SCXRD analysis reveals phenyl groups ring engage intramolecular π‐stacking interaction only which significantly enhances its stability. needle‐shaped crystals thermodynamically stable ‐ display exceptional elastic mechanical flexibility, whilst plate‐like ‐isomers brittle. quantitative difference properties both isomers exhibited by nanoindentation experiments. softer than ones roughly three‐fold characteristics identified.
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Photopharmacology offers the promise of optical modulation cellular signaling in a spatially and temporally controlled fashion with light-sensitive molecules. This study presents first small-molecule photoswitchable agonist for an atypical G protein-coupled receptor (GPCR), chemokine 3 (ACKR3). Inspired by known benzylpiperidine-based ACKR3 scaffold, 12 azobenzene-containing analogs were synthesized characterized their interaction ACKR3. After analysis concise Structure-Photochemistry Structure-Affinity Relationships (SAR), compound 3e was selected as best series. Compound can be effectively switched from its thermodynamically stable trans state to less active cis-isomer photostationary 96%. The cis- only slowly switches back (t 1/2,37°C ∼ 15 days), trans-3e binds activates at 10-fold lower concentrations compared cis-isomer. demonstrates selectivity within wide panel receptors. Using recently published cryo-EM structures computational studies, binding mode is proposed that perfectly line observed SAR reduction upon photoswitching. (VUF25471) ligand GPCR will useful tool investigate role biological settings.
Language: Английский
Citations
0
Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
The use of photoswitchable ligand to control the protein functionalities and related downstream effects in an on-off manner is active research area photopharmacology medicinal chemistry. Temporal grants a privilege identify crucial role particular receptor biological occurrences without destroying permanently. Additionally, light can be applied site-selectively regulate functionality with cellular sub-cellular levels spatial resolutions. spatiotemporal resolution enables probing specific receptor, isoform, or signalling pathway. This reversible fast highly beneficial studying dynamic processes, including but not limited signal transduction, neurotransmission, cell divisions, immune response, folding, degradation. Though several light-active ligands have been developed efficiently, only few reports on exist literature. Major challenges achieve efficient photoswitches study are synthesis strategy, photostability ligand, bidirectional visible switching ability most importantly precise controlling local concentration desired photoisomer using light. site-specific localization depends multiple factors like nature photoswitch, binding affinity both photoisomers, molecular diffusion irradiation conditions. present review discusses suitable techniques different achieving subcellular dimension functionality. Multiple strategies discussed, along their advantages limitations, explore enormous potentiality these approaches manipulating
Language: Английский
Citations
0
RSC Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review covers the history of light therapy, emergence photopharmacology, its methods, and challenges. Current advancements show promise for treating diseases like cancer with precision minimal side effects.
Language: Английский
Citations
0
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111064 - 111064
Published: March 1, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Abstract Azobenzene‐based chiral photoswitches are widely used as photoresponsive dopants in cholesteric liquid crystals (CLCs) due to their ability dynamically tune supramolecular helices and have attracted considerable attention recent years. However, a challenge for application is the thermal instability of Z ‐isomers, causing photoaddressed images be thermally erased at room temperature within few hours. Here series new binaphthylazopyrazole reported, with good bidirectional photoconversions tunable half‐lives up two months because incorporated pyrazole ring T‐shaped isomer conformation. By co‐doping these switches photoinsensitive dopant S5011 into crystal host E7, CLCs high stability reflective color modulation obtained. Specifically, tuning across entire visible region achieved colorful can retained dark least 1 week. In addition, large helical twisting power variation, handedness inversion under 365 nm light irradiation also observed. These results provide guidance expanding diversity heteroaryl azo demonstrate great potential developing stable RGB colors.
Language: Английский
Citations
0
Advanced Optical Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 22, 2025
Abstract Achieving time‐resolved information encryption is crucial for advanced functional materials but remains a formidable challenge. Photoresponsive supramolecular assemblies have gained attention as promising candidates in this area. This work presents unique strategy that employs α ‐cyanostilbenes to construct photoresponsive which enable finely regulating fluorescence color and photoresponse kinetics, facilitating effective encryption. Three 1 – 3 are designed by the combination of electron donor 3,4‐ethoxylene dioxythiophene appended benzaldehyde with acceptor phenylacetonitrile different substituents. All three compounds undergo reversible Z/E isomerization CH CN under 420 254 nm light irradiation. Interestingly, while CN/H 2 O high water content (95%), these found be able self‐assemble into spherical reduced molecular distances. Remarkably, upon exposure visible light, [2+2] cycloadditions occur within assemblies, exhibiting distinct kinetics variations due formation cycloaddition products, confirmed H NMR spectroscopy, high‐resolution mass spectrometry, single crystal structures. Furthermore, their changes demonstrate potential applications hydrogel‐based photo‐patterning. research offers compelling designing visible‐light‐driven fluorescent switching high‐level beyond.
Language: Английский
Citations
0
Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics photopharmacology, offers the potential to modulate AR signaling with precise temporal spatial resolution. In this review, we summarize latest advancements signaling, encompassing optogenetics, photocaged compounds, photoswitchable compounds. We also discuss limitations current tools provide an outlook on next generation optogenetic photopharmacological tools. These emerging technologies not only enhance our understanding but pave way for developments.
Language: Английский
Citations
0
Langmuir, Journal Year: 2025, Volume and Issue: unknown
Published: April 16, 2025
This study presents a novel, eco-friendly, and cost-effective magnetic hybrid photocatalyst, Fe3O4@SiO2/L-tryptophan, synthesized through scalable three-step green approach using natural agricultural waste. The Fe3O4@SiO2/L-tryptophan nanoparticle features core-shell structure with high surface area (63.14 m2/g), strong visible-light absorption (λ > 448 nm), narrow band gap (1.84 eV), superparamagnetic properties (22 emu/g), enabling efficient separation reusability. Characterization techniques (XRD, XPS, FT-IR, FE-SEM, HR-TEM, UV-vis DRS, TGA, BET, EIS) confirmed its structural stability, charge separation, interfacial transport. photocatalyst achieved 82.1% oxidative desulfurization of dibenzothiophene (DBT) conversion rates for toluene (85%) styrene (90%) under visible light O2 as an oxidant. It retained over 85% activity after five cycles, demonstrating excellent durability. For the first time, all components are derived from sources: Fe3O4 sorghum seed extract, SiO2 rice husk, L-tryptophan enhanced separation. sustainable synthesis reduces chemical waste energy consumption, setting new benchmark environmentally friendly photocatalysts.
Language: Английский
Citations
0