Cited by Selective C‐Methylenation of N‐Unsubstituted Indoles Using CO2 Under NaBH4/I2 System

N-Iodosuccinimide-Promoted Synthesis of Indolo[3,2-c]quinolizines via Cascade Intramolecular C–N Bond Formation/Aromatization with 3-(1H-Indol-3-yl)-2-(pyridin-2-yl)propanoates DOI

Chen Chen, Xixiang Yang, Jiaxin Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

An NIS-promoted cascade of intramolecular C-N bond formation/aromatization with 3-(1H-indol-3-yl)-2-(pyridin-2-yl)propanoates is described for synthesizing a polycyclic indole skeleton, indolo[3,2-c]quinolizine, as well 1,9-dihydropyrazolo[4',3':5,6]pyrido[2,3-b]indole. The advantages this protocol include accessible starting materials, mild conditions, simple operation, and good yields. Indolo[3,2-c]quinolizines exhibited fluorescence properties effective staining live cells, targeting lysosomes mitochondria. Additionally, the products showed significant antiproliferative activity against tumor cells in MTT assay.

Language: Английский

Citations

Substrate-Controlled Divergent Reductive Cyclization of 2-Arylanilines Using CO₂ as a Switching Reagent DOI

Qiang Yan, Jiang Nan,

Rui Cao

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 27(1), P. 510 - 516

Published: Dec. 30, 2024

Capturing CO2 is highly valued in the field of organic synthesis, especially underdeveloped dual-CO2 conversion. In this study, we detail a novel reductive cyclization 2-indolylanilines with dual as difunctional reagent presence PMHS [poly(methylhydrosiloxane)], delivering methyl-substituted quinoxalines. Furthermore, another chemoselective 2-pyrrolylanilines also realized by converting mono-CO2. Mechanistic investigations shed light upon fact that substrate-controlled divergence mainly depends on formation N-diacylative intermediates.

Language: Английский

Citations

The Silane-Promoted Cycloaddition of Thiobenzhydrazide with Carbon Dioxide toward 1,3,4-Thiadiazol-2(3H)-one DOI

Hailong Chen,

Junhang Gao,

Yang Zhao

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Herein, we developed a silane-promoted cycloaddition of thiobenzhydrazides with carbon dioxide leading to 1,3,4-thiadiazol-2(3 H )-ones.

Language: Английский

Citations

Selective C‐Methylenation of N‐Unsubstituted Indoles Using CO2 Under NaBH4/I2 System DOI

Zhiqiang Guo,

Jinglong Wu,

Xue-Hong Wei

et al.

ChemSusChem, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

The selective C-methylenation of N-unsubstituted indoles using CO

Language: Английский

Citations