Multi-Aryl Pyrroles: Exploring Aggregation-Induced Emission for the Biological/Medical Applications

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112633 - 112633

Published: Jan. 1, 2025

Language: Английский

Molecular Fragmentation and Recombination for the Synthesis of GFP Chromophore Analogues

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 90(4), P. 1678 - 1682

Published: Jan. 20, 2025

Green fluorescent protein (GFP) chromophores are widely studied as moieties for sensing and imaging applications. Herein, we present a straightforward synthetic strategy that involves the reaction of glycine amides with 1,3-diketones to form imidazolones through an unusual molecular fragmentation recombination pathway. Mechanistic investigations, including crossover experiments, inspired competing incorporates exogenous ketones into products, yielding GFP chromophore analogues. This method holds potential labeling glycine-terminated peptides.

Language: Английский

Trendbericht: Organische Chemie 2025

Nachrichten aus der Chemie, Journal Year: 2025, Volume and Issue: 73(3), P. 40 - 70

Published: Feb. 28, 2025

Abstract Highlights von November 2023 bis 2024: die erste Einelektron‐C–C‐σ‐Bindung und Anti‐Bredt‐Verbindung; gesättigte Heterocyclen elektrochemisch funktionalisieren; Ausrichten diskotischer Flüssigkristalle; enantioselektive Wagner‐Meerwein‐Umlagerung reiner Aliphaten; photokatalytisch Furanen zu Pyrrolen; mit Ammoniak primären Arylaminen; Metallschrott recyceln ionischen Flüssigkeiten; terminale Alkene Ni‐Katalysatoren zum (Z)‐ oder (E)‐Alken isomerisieren;neue Fungizide, Medikamente Alkaloide.