Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 619 - 631
Published: Nov. 29, 2024
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Sept. 28, 2024
Language: Английский
Citations
17
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1582 - 1582
Published: Dec. 11, 2024
Background: Achieving a balance between stable drug loading/delivery and on-demand activation/release at the target sites remains significant challenge for nanomedicines. Carrier-free prodrug nanoassemblies, which rely on design of molecules, offer promising strategy to optimize both delivery efficiency controlled release profiles. Methods: A library doxorubicin (DOX) prodrugs was created by linking DOX fatty alcohols varying chain lengths via tumor-responsive disulfide bond. In vitro studies assessed stability kinetics nanoassemblies. vivo evaluated their efficiency, tumor accumulation, antitumor activity in mouse models. Results: results demonstrated that longer alcohol chains improved nanoassemblies but slowed down disassembly process. DSSC16 NAs (hexadecanol-modified prodrug) significantly prolonged blood circulation time enhanced with AUC values 14.2-fold higher than DiR Sol. 4T1 tumor-bearing models, exhibited notably stronger activity, resulting final mean volume 144.39 ± 36.77 mm3, smaller all other groups (p < 0.05 ANOVA 95% confidence interval). Conclusions: These findings underscore critical role molecule development effective The is pivotal optimizing maximizing therapeutic efficacy.
Language: Английский
Citations
12
Nano Today, Journal Year: 2024, Volume and Issue: 61, P. 102604 - 102604
Published: Dec. 19, 2024
Language: Английский
Citations
5
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 684, P. 97 - 108
Published: Jan. 4, 2025
Language: Английский
Citations
0
Chinese Science Bulletin (Chinese Version), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This study introduces a novel and efficient approach for constructing stimulus-responsive polycarbonates with tunable stimulus sensitivity by tailoring nanoparticle core hydrophobicity.
Language: Английский
Citations
0
Polymers, Journal Year: 2025, Volume and Issue: 17(8), P. 1010 - 1010
Published: April 9, 2025
Hypoxic tumors pose considerable obstacles to cancer treatment, as diminished oxygen levels can impair drug effectiveness and heighten therapeutic resistance. Oral cancer, a prevalent malignancy, encounters specific challenges owing its intricate anatomical structure the technical difficulties in achieving complete resection, thereby often restricting treatment efficacy. The impact of hypoxia is particularly critical influencing both response prognosis oral cancers. This article summarizes examines potential polymer nanomedicines address these challenges. By engineering that specifically react hypoxic tumor microenvironment, pharmaceuticals markedly enhance targeting precision effectiveness. Polymer efficacy while reducing side effects by hypoxia-targeted accumulation. emphasizes overcome resistance frequently observed improving delivery bioavailability anticancer agents. Furthermore, this review elucidates design application for treating tumors, highlighting their transformative therapy. Finally, gives an outlook on stimuli-responsive polymeric cancer.
Language: Английский
Citations
0
Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 20, 2025
Comprehensive Summary Self‐assembly processes are ubiquitous in biological systems, playing essential roles sustaining life activities. The exploration of self‐assembled biomaterials (SABMs) holds great potential for advancing various fields, particularly biomedicine and materials science. Because the unique reversibility responsiveness to stimuli, dynamic covalent bonds (DCBs) noncovalent (NCBs) endow SABMs with self‐healing properties, stimuli controllable degradation, making them highly versatile a wide range biomedical applications. In this article, recent advances future trends based on DCBs NCBs thoroughly reviewed. We begin by introducing molecular principles characteristics that govern formation SABMs. also explore responsive functional features these detail. Finally, we summarize perspectives challenges associated development aim review offer comprehensive overview SABMs, serving as valuable resource chemists scientists striving further advance design Key Scientists
Language: Английский
Citations
0
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 22, 2025
The rational design of tumor-responsive prodrug nanoassemblies requires precise control over systemic stability and site-specific activation. While α-position disulfide bonds are advantageous for rapid response to redox conditions, they also risk premature drug leakage during circulation. This study introduces a steric hindrance-guided approach engineer disulfide-bridged podophyllotoxin homodimeric prodrugs spatiotemporal controlled delivery. By monomethyl or dimethyl substitution the carbon atoms adjacent α-disulfide bond, we can modulate hindrance. Excessive hindrance destabilizes slows effective release, while moderate (monomethyl modification) enhances pharmacokinetic properties promotes selective tumor In vivo studies indicate that monomethyl-modified exhibit superior antitumor efficacy reduced off-target toxicity compared PPT solution. work underscores importance in optimizing nanoassembly tumor-specific activation, offering comprehensive strategy redox-responsive nanomedicines.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113699 - 113699
Published: April 1, 2025
Language: Английский
Citations
0