Lysosome‐Targeted Bifunctional Fluorescent Probe and Type I/II Photosensitizer for Viscosity Imaging and Cancer Photodynamic Therapy DOI Open Access

Du Liu,

Hongyan An,

Xianglong Li

et al.

Luminescence, Journal Year: 2024, Volume and Issue: 39(11)

Published: Nov. 1, 2024

Abnormal lysosomal viscosity is closely associated with cancer progression, underscoring the need for bifunctional fluorescent probes and photosensitizers (PSs) that can both monitor facilitate imaging-guided therapy simultaneous diagnosis treatment. Despite advances in lysosome-targeted PSs development, few have demonstrated ability to generate Type I II reactive oxygen species (ROS). In this study, we present BTTPA, a probe photosensitizer, designed integrate via imaging treatment through photodynamic (PDT). Our findings reveal BTTPA selectively targets lysosomes, enabling dynamic monitoring of cellular distinguishing cells from normal cells. Upon light activation, efficiently generates ROS. Apoptosis assays further confirm BTTPA's effectiveness inducing cell apoptosis, highlighting its potential as powerful tool therapy.

Language: Английский

Cu-Doped MnO2 Nanoparticles Loaded with Docetaxel Synergistically Enhance Chemodynamic Therapy through Ferroptosis and Cuproptosis DOI

Lekang Liu,

Mingbo Shao,

Linna Guo

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

We have developed an innovative Cu-doped and DTX-loaded Cu-MnO2@DTX@FA (MCDF) nanodrug designed to strategically alter tumor microenvironment (TME) by harnessing the synergistic effects of chemodynamic therapy (CDT), chemotherapeutic agents, induction ferroptosis cuproptosis. The MCDF efficiently degrades, releasing abundant Mn4+, Cu2+, DTX. conversion Cu2+ Cu+ facilitated FDX1 initiates cuproptosis, while, similar Mn2+, reacts with hydrogen peroxide (H2O2) generate hydroxyl radicals (·OH). Mn4+ oxidize glutathione (GSH), significantly depleting GSH levels in cells inactivating GPX4, which further promotes ferroptosis. release intensifies DTX effectively disrupts cell division cycle, thereby inhibiting proliferation spread cells. FA-modified is evade immune detection while selectively targeting tissues, ensuring precision treatment delivery. This cutting-edge material not only provides a multifunctional therapeutic strategy but also sets stage for next generation tumor-targeting nanomedicines.

Language: Английский

Citations

1
Beyond chemotherapy: Spatiotemporal activation of metal complexes for deep-tissues precision medicine DOI

Yida Pang,

Fang Zhao, Yuting Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216664 - 216664

Published: March 30, 2025

Language: Английский

Citations

0
Renal-Clearable Molecular Reporters for Near-Infrared Fluorescence Imaging and Urinalysis of Pulmonary Metastatic Tumor DOI

Ya Zhou,

Jun Chen, Yang Zhou

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Despite approximately 40% of all patients with cancer developing pulmonary metastases in the course their disease, it remains a diagnostic challenge clinical practice. Herein, we propose fluorogenic probe (CPRG) gamma-glutamyl transferase (GGT)-triggered signal turn-on for near-infrared fluorescence imaging (NIRF) and urinalysis orthotopic metastatic tumors living mice. CPRG comprised four key moieties: GGT-reactive moiety, hemicyanine-based unit, polyethylene glycol linker, an active tumor targeting moiety. Such tailored is intrinsically nonfluorescent only activates its NIRF signals presence GGT. After intratracheal administration into lungs tumor-bearing mice, can efficiently accumulate sensitively real-time imaging. Relying on high renal clearance efficiency (∼70% ID), be rapidly excreted through kidneys assessed by chemotherapeutic efficacy cisplatin. This study not reports tracers but also provides guidelines development molecular probes companion diagnosis cancer.

Language: Английский

Citations

0
Dinuclear Ru(II) Complexes for Synergetic Photodynamic, Photothermal, and Sonodynamic Therapy against Cisplatin-Resistant Cancer DOI
Xiaoxia Ren, Xuelian Li, Runyu Zhao

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

A new series of dinuclear Ru(II) complexes with a novel bridging ligand were developed for the treatment cisplatin-resistant non-small-cell lung cancer via synergistic photodynamic, photothermal, and sonodynamic therapy mechanism. Comprehensive experimental theoretical studies investigated their photophysical photochemical properties along influence ancillary ligands. The exhibit significant two-photon absorption at IR region, facilitating ROS generation through both type I II mechanisms under laser ultrasound exposure. They effectively target mitochondria nuclei, regulating DNA-related mechanisms, including inhibition DNA topoisomerase RNA polymerase while promoting photoactivated apoptosis ferroptosis. high synergy effect between was attributed to rise in oxygen availability ultrasound-induced cavitation thermal-induced increase vascular permeability partial pressure. In vivo experiments confirmed that combination yielded superior therapeutic outcomes compared single-modality treatments. tested complex exhibited excellent safety rapid clearance low toxicity normal cells. These findings suggest IR-activated metal can significantly advance integrated diagnostic approaches, overcoming challenges such as drug resistance hypoxic environments deep tumors.

Language: Английский

Citations

0
Homologous-Targeting Porous Type I/II Nanophotosensitizers for Efficient Delivery of STING Agonists and Enhanced Photodynamic Cancer Immunotherapy DOI
Debabrata Dutta, Xin Chen, Li Cheng

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Immunotherapy as a transformative cancer treatment modality frequently struggles with the immunosuppressive tumor microenvironment, which hinders effective immune responses. In this report, we construct biomimetic cell membrane-cloaked porous covalent organic framework (COF) nanophotosensitizers (CMSCOFs) to synergistically enhance photodynamic therapy (PDT) and stimulate interferon genes (STING)-mediated immunotherapy. CMSCOF is prepared from porphyrin benzothiadiazole-based units cloaked 4T1 membranes for homologous targeting. The structure of COF enables efficient encapsulation non-nucleotide STING agonist SR717. Upon 660 nm light irradiation, CMSCOFs trigger both type I II effects by producing superoxide (O2•-) singlet oxygen (1O2). design improves stability mimics natural cells enhanced blood circulation, accumulation, homologous-targeting tumors. Inside tissues, unique leads immunogenic death (ICD) upon exposure irradiation. Furthermore, encapsulated SR717 released after cellular internalization activate pathway elicit potent antitumor response. This synergistic approach effectively reverses enhances cytotoxic T infiltration, suppresses primary metastatic tumors, demonstrating potential promising platform

Language: Английский

Citations

0
A comprehensive overview on mononuclear and multinuclear Ruthenium-based coordination compounds as breast cancer therapeutics DOI
Madiha Naseem, Amna Siddique, Muhammad Sohail Latif

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114718 - 114718

Published: May 1, 2025

Language: Английский

Citations

0
Substituent‐Modulated Excited Triplet States and Activities of Ruthenium Complexes for Dual Photodynamic/Sonodynamic Therapy to Cisplatin‐Resistant Non‐Small Cell Lung Cancer DOI

Dan-Dan Xie,

Xuelian Li,

Lizhen Zeng

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Six polypyridyl Ru(II) complexes were designed for single-molecule photodynamic and sonodynamic therapy (PDT/SDT) synergistic multimodal anticancer toward cisplatin-resistant NSCLC. They demonstrated lowest 3ES with distinct intraligand transition nature, which is beneficial singlet oxygen generation. Remarkable quantum yields of both superoxide anion under either 808 nm laser irradiation or ultrasonic treatment could induce apoptosis ferroptosis A549R cells. Cytotoxicity experiments clearly a effect between PDT SDT. The relationship the structures these their cellular biological mechanisms has been explored in detail. Using sensitizer to achieve PDT/SDT may provide valuable insights drug-resistant tumors that located deeply hypoxic microenvironment.

Language: Английский

Citations

2
Lysosome‐Targeted Bifunctional Fluorescent Probe and Type I/II Photosensitizer for Viscosity Imaging and Cancer Photodynamic Therapy DOI Open Access

Du Liu,

Hongyan An,

Xianglong Li

et al.

Luminescence, Journal Year: 2024, Volume and Issue: 39(11)

Published: Nov. 1, 2024

Abnormal lysosomal viscosity is closely associated with cancer progression, underscoring the need for bifunctional fluorescent probes and photosensitizers (PSs) that can both monitor facilitate imaging-guided therapy simultaneous diagnosis treatment. Despite advances in lysosome-targeted PSs development, few have demonstrated ability to generate Type I II reactive oxygen species (ROS). In this study, we present BTTPA, a probe photosensitizer, designed integrate via imaging treatment through photodynamic (PDT). Our findings reveal BTTPA selectively targets lysosomes, enabling dynamic monitoring of cellular distinguishing cells from normal cells. Upon light activation, efficiently generates ROS. Apoptosis assays further confirm BTTPA's effectiveness inducing cell apoptosis, highlighting its potential as powerful tool therapy.

Language: Английский

Citations

0