Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(1), P. 38 - 71

Published: Nov. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Language: Английский

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Molecular afterglow imaging with bright, biodegradable polymer nanoparticles

Nature Biotechnology, Journal Year: 2017, Volume and Issue: 35(11), P. 1102 - 1110

Published: Oct. 16, 2017

Language: Английский

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Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(13), P. 5359 - 5368

Published: March 13, 2019

Planar donor and acceptor (D–A) conjugated structures are generally believed to be the standard for architecting highly efficient photothermal theranostic agents, in order restrict intramolecular motions aggregates (nanoparticles). However, other channels of extra nonradiative decay may blocked. Now this challenge is addressed by proposing an "abnormal" strategy based on molecular motion aggregates. Molecular rotors bulky alkyl chains grafted central D–A core lower intermolecular interaction. The enhanced favors formation a dark twisted charge transfer state, whose enhances properties. Result shows that small-molecule NIRb14 with long branched at second carbon exhibits properties compared NIRb6, short chains, much higher than NIR6, linear commercial gold nanorods. Both vitro vivo experiments demonstrate nanoparticles can used as nanoagents photoacoustic imaging-guided therapy. Moreover, reversal poly(β-amino ester) makes specifically accumulate tumor sites. This study thus provides excited approach toward phototheranostic agents.

Language: Английский

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Dual‐Peak Absorbing Semiconducting Copolymer Nanoparticles for First and Second Near‐Infrared Window Photothermal Therapy: A Comparative Study

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(14)

Published: Feb. 19, 2018

Near-infrared (NIR) light is widely used for noninvasive optical diagnosis and phototherapy. However, current research focuses on the first NIR window (NIR-I, 650-950 nm), while second (NIR-II, 1000-1700 nm) far less exploited. The development of organic photothermal nanoagent (SPNI-II ) with dual-peak absorption in both windows its utilization therapy (PTT) are reported herein. Such a comprises semiconducting copolymer two distinct segments that respectively identically absorb at 808 1064 nm. With conversion efficiency 43.4% nm generally higher than other inorganic nanomaterials, SPNI-II enables superior deep-tissue heating over their respective safety limits. Model cancer PTT tissue depth 5 mm validates enhanced antitumor effect when shifting laser irradiation from NIR-I to NIR-II window. good biodistribution facile synthesis also allow it be doped an dye fluorescence-imaging-guided through systemic administration. Thus, this study paves way new polymeric nanomaterials advance

Language: Английский

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Antiferromagnetic Pyrite as the Tumor Microenvironment‐Mediated Nanoplatform for Self‐Enhanced Tumor Imaging and Therapy

Advanced Materials, Journal Year: 2017, Volume and Issue: 29(47)

Published: Nov. 2, 2017

Several decades of research have identified the specific tumor microenvironment (TME) to develop promising nanotheranostics, such as pH-sensitive imaging, acidity-sensitive starving therapy, and hydrogen peroxide-activated chemotherapy, etc. Herein, a novel TME-mediated nanoplatform employing antiferromagnetic pyrite nanocubes is presented, exploiting intratumoral, overproduced peroxide for self-enhanced magnetic resonance imaging (MRI) photothermal therapy (PTT)/chemodynamic (CDT). Through activation excessive in microenvironment, can lead situ surface oxidation generate hydroxyl radicals kill cells (i.e., CDT). The increase valence state Fe significantly promotes performance MRI accompanied by CDT. Furthermore, localized heat treatment accelerate intratumoral Fenton process, enabling synergetic PTT/CDT. To our best knowledge, this first study use TME-response valence-variable strategy based on developing nanotheranostic, which will open up new dimension design other TME-based anticancer strategies.

Language: Английский

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Ultralong Phosphorescence of Water‐Soluble Organic Nanoparticles for In Vivo Afterglow Imaging

Advanced Materials, Journal Year: 2017, Volume and Issue: 29(33)

Published: June 28, 2017

Afterglow or persistent luminescence eliminates the need for light excitation and thus circumvents issue of autofluorescence, holding promise molecular imaging. However, current agents are rare limited to inorganic nanoparticles. This study reports design principle, synthesis, proof-of-concept application organic semiconducting nanoparticles (OSNs) with ultralong phosphorescence in vivo afterglow The principle leverages formation aggregates through a top-down nanoparticle formulation greatly stabilize triplet excited states phosphorescent molecule. prolongs particle luminesce timescale that can be detected by commercial whole-animal imaging system after removal external source. Such OSNs is inert oxygen repeatedly activated, permitting lymph nodes living mice high signal-to-noise ratio. not only introduces first category water-soluble but also reveals universal prolong lifetime molecules level effective

Language: Английский

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Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(49)

Published: July 29, 2018

Optical imaging has played a pivotal role in biology and medicine, but it faces challenges of relatively low tissue penetration poor signal-to-background ratio due to light scattering autofluorescence. To overcome these issues, second near-infrared fluorescence, self-luminescence, photoacoustic have recently emerged, which utilize an optical region with reduced light-tissue interactions, eliminate real-time excitation, detect acoustic signals negligible attenuation, respectively. Because there are only few endogenous molecules absorbing or emitting above the visible region, development contrast agents is essential for those deep-tissue modalities. Organic semiconducting π-conjugated frameworks can be synthesized meet different requirements their easy chemical modification legible structure-property relation. Herein, applications organic including small-molecule nanoparticle derivatives summarized. In particular, molecular engineering nanoformulation approaches further improve detection sensitivity modalities highlighted. Finally, current potential opportunities this emerging subfield biomedical discussed.

Language: Английский

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Near‐Infrared (NIR) Organic Light‐Emitting Diodes (OLEDs): Challenges and Opportunities

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 29(21)

Published: Jan. 30, 2019

Abstract The rapid development of the science and technology organic semiconductors has already led to mass application light‐emitting diodes (OLEDs) in television monitors outstanding quality as well a large variety smaller displays found smartphones, tablets, other gadgets, while introduction illumination sector is imminent. Notably, requirements all such applications for emission visible range electromagnetic spectrum are tuned optical electronic properties typical semiconductors, thereby representing relatively “low‐hanging fruits,” terms material exploitation. However, question arises whether developing materials suited efficient near‐infrared (NIR, 700–1000 nm) possible, and, crucially, desirable enable new classes spanning from through‐space, short‐range communications biomedical sensors, night vision, more generally security name but few. Here, major fundamental hurdles be overcome achieve NIR π‐conjugated systems discussed, recent progress reviewed, an outlook further both provided.

Language: Английский

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Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance

Journal of the American Chemical Society, Journal Year: 2018, Volume and Issue: 140(5), P. 1715 - 1724

Published: Jan. 16, 2018

Organic fluorophores have been widely used for biological imaging in the visible and first near-infrared windows. However, their application second window (NIR-II, 1000–1700 nm) is still limited mainly due to low fluorescence quantum yields (QYs). Here, we explore molecular engineering on donor unit develop high performance NIR-II fluorophores. The are constructed by a shielding unit–donor(s)–acceptor–donor(s)–shielding structure. Thiophene introduced as connected unit, which can increase conjugation length red-shift emission. Alkyl thiophene employed acceptor unit. bulky hydrophobic alkyl affords larger distortion of conjugated backbone fewer interactions with water molecules compared other units studied before. fluorophore IR-FTAP octyl exhibits emission peaked at 1048 nm QY 5.3% aqueous solutions, one highest reported so far. Superior temporal spatial resolutions demonstrated blood vessels mouse hindlimb.

Language: Английский

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Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy

Small, Journal Year: 2018, Volume and Issue: 15(1)

Published: Nov. 20, 2018

Abstract Phototherapy including photothermal therapy (PTT) and photodynamic (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional include easy recognition immune system, rapid clearance from blood circulation, low accumulation in target sites. Cell‐membrane coating emerged as a potential way overcome these limitations, owing abundant proteins on surface of cell membranes that can be inherited membrane–camouflaged nanoparticles. This review summarizes recent advances development biomimetic nanoparticles phototherapy. Different sources used coat uisng different approaches. After cell‐membrane coating, photophysical properties original remain nearly unchanged; however, coated are equipped with additional physiological features escape, vivo prolonged circulation time, homologous targeting, depending sources. Moreover, membrane ablated under laser irradiation, leading drug release thus synergetic By combining other supplementary normalize tumor microenvironment, further enhance therapeutic efficacy against cancer.

Language: Английский

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