Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(6), P. 4185 - 4219

Published: Jan. 1, 2021

Molecular design directions for overcoming the photodynamic therapy challenges.

Language: Английский

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Tailoring the photoluminescence of atomically precise nanoclusters

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(8), P. 2422 - 2457

Published: Jan. 1, 2019

Fluorescent nanoclusters are an emerging class of modular nanomaterials. This review highlights recent developments in tailoring the photo-luminescence nanoclusters.

Language: Английский

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Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(24)

Published: April 26, 2019

Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target variety of biological tissues processes. This review focuses on summarizing organic dyes emitting at transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with surrounding allows photons travel nearly unperturbed throughout body. NIR-II fluorescence imaging overcomes penetration/contrast bottleneck in visible region, making it remarkable modality early diagnosis cancer highly sensitive tumor surgery. Due their convenient bioconjugation peptides/antibodies, molecular are desirable candidates targeted imaging, significantly overcoming autofluorescence/scattering issues deep tissue imaging. To promote clinical translation bioimaging, advancements high-performance small molecule-derived probes critically important. Here, molecules potential discussed, synthesis chemical structures dyes, optical properties behavior whole body detection surgery, as well microscopy A key perspective direction surgery is also discussed.

Language: Английский

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The light of carbon dots: From mechanism to applications

Matter, Journal Year: 2022, Volume and Issue: 5(1), P. 110 - 149

Published: Jan. 1, 2022

Language: Английский

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Emerging combination strategies with phototherapy in cancer nanomedicine

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8065 - 8087

Published: Jan. 1, 2020

Based on the challenges in single-mode phototherapy, this review summarizes significant research progress combinatorial strategies with phototherapy.

Language: Английский

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Design of superior phototheranostic agents guided by Jablonski diagrams

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

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Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(13), P. 5359 - 5368

Published: March 13, 2019

Planar donor and acceptor (D–A) conjugated structures are generally believed to be the standard for architecting highly efficient photothermal theranostic agents, in order restrict intramolecular motions aggregates (nanoparticles). However, other channels of extra nonradiative decay may blocked. Now this challenge is addressed by proposing an "abnormal" strategy based on molecular motion aggregates. Molecular rotors bulky alkyl chains grafted central D–A core lower intermolecular interaction. The enhanced favors formation a dark twisted charge transfer state, whose enhances properties. Result shows that small-molecule NIRb14 with long branched at second carbon exhibits properties compared NIRb6, short chains, much higher than NIR6, linear commercial gold nanorods. Both vitro vivo experiments demonstrate nanoparticles can used as nanoagents photoacoustic imaging-guided therapy. Moreover, reversal poly(β-amino ester) makes specifically accumulate tumor sites. This study thus provides excited approach toward phototheranostic agents.

Language: Английский

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(47)

Published: Oct. 16, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such deeper penetration depth, absence of phototoxicity, fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks the facile engineering nature nanotechnology, numerous novel nanoplatforms being applied this emerging field tackle these barriers achieve continuous innovations. In particular, combination other treatment strategies superior efficacy improving anticancer activity relative that monotherapies alone. Therefore, it is necessary summarize nanomaterial-assisted combinational cancer applications. Herein, design principles achieving synergistic effects based on nanomaterial methods highlighted. The ultimate goals stimulate better-quality combined schemes provide innovative ideas perspectives promoting future transformation clinical application.

Language: Английский

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Activatable Molecular Probes for Second Near‐Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(29), P. 11717 - 11731

Published: March 5, 2020

Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence biological tissue between 650-900 nm, conventional optical often has poor signal-to-background ratio shallow penetration depth, which limits its ability deep-tissue vivo imaging. Second near-infrared fluorescence, chemiluminescence, photoacoustic modalities mitigate these issues by their respective advantages of minimized scattering, eliminated external excitation, ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the change second or signals response biomarker have been developed. This Minireview summarizes design strategies, sensing mechanisms, applications AMPs. The potential challenges perspectives AMPs are also discussed.

Language: Английский

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Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Polymers, Journal Year: 2020, Volume and Issue: 12(6), P. 1397 - 1397

Published: June 22, 2020

In the past few decades, polymeric nanocarriers have been recognized as promising tools and gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical biomedical applications. Remarkably, these could be further modified stimuli-responsive systems based on mechanism of triggered release, i.e., response a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) effective biodistribution controlled release drugs genes at sites. Various nanoparticles (NPs) functionalized used templates imaging form metallic NPs, dendrimers, quantum dots, liposomes. The use active compounds has attracted considerable interest various cancer therapy fields. So-called smart nanopolymer are built respond certain stimuli such pH, light intensity wavelength, electrical, magnetic ultrasonic Many techniques explored optical imaging, resonance (MRI), nuclear photoacoustic (PAI), single photon emission computed tomography (SPECT), positron (PET). This review reports most recent developments methods by analyzing examples nanopolymers that can imaged using one more techniques. Unique features, nontoxicity, water solubility, biocompatibility, presence multiple functional groups, designate nanocues attractive nanomedicine candidates. this context, we summarize classes multifunctional, polymeric, nano-sized formulations liposomes, micelles, nanogels, dendrimers.

Language: Английский

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