Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
58(40), P. 14357 - 14364
Published: July 31, 2019
A
large
range
of
nanoparticles
have
been
developed
to
encapsulate
hydrophobic
drugs.
However,
drug
loading
is
usually
less
than
10
%
or
even
1
%.
Now,
core-shell
are
fabricated
having
exceptionally
high
up
65
(drug
weight/the
total
weight
drug-loaded
nanoparticles)
and
encapsulation
efficiencies
(>99
%)
based
on
modular
biomolecule
templating.
Bifunctional
amphiphilic
peptides
designed
not
only
stabilize
but
also
induce
biosilicification
at
the
nanodrug
particle
surface
thus
forming
drug-core
silica-shell
nanocomposites.
This
platform
technology
highly
versatile
for
encapsulating
various
cargos.
Furthermore,
lead
better
in
vitro
cytotoxic
effects
vivo
suppression
tumor
growth,
highlighting
significance
using
drug-loading
nanoparticles.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
31(3)
Published: Sept. 10, 2018
Abstract
Recently,
diverse
functional
materials
that
take
subcellular
structures
as
therapeutic
targets
are
playing
increasingly
important
roles
in
cancer
therapy.
Here,
particular
emphasis
is
placed
on
four
kinds
of
therapies,
including
chemotherapy,
gene
therapy,
photodynamic
therapy
(PDT),
and
hyperthermal
which
the
most
widely
used
approaches
for
killing
cells
by
specific
destruction
organelles.
Moreover,
some
non‐drug‐loaded
nanoformulations
(i.e.,
metal
nanoparticles
molecular
self‐assemblies)
with
a
fatal
effect
influencing
functions
without
use
any
drug
molecules
also
included.
According
to
basic
principles
unique
performances
each
treatment,
appropriate
strategies
developed
meet
task‐specific
applications
integrating
materials,
ligands,
well
methods.
In
addition,
combination
two
or
more
therapies
based
multifunctional
nanostructures,
either
directly
target
organelles
release
organelle‐targeted
therapeutics,
introduced
intent
superadditive
effects.
Finally,
related
challenges
critical
re‐evaluation
this
emerging
field
presented.
ACS Applied Materials & Interfaces,
Journal Year:
2018,
Volume and Issue:
10(13), P. 10664 - 10677
Published: March 6, 2018
Nucleolus
tracking
and
nucleus-targeted
photodynamic
therapy
are
attracting
increasing
attention
due
to
the
importance
of
nucleolus
sensitivity
nucleus
various
therapeutic
stimuli.
Herein,
a
new
class
multifunctional
fluorescent
carbon
quantum
dots
(or
dots,
CDs)
synthesized
via
one-pot
hydrothermal
reaction
m-phenylenediamine
l-cysteine
was
reported
effectively
target
nucleolus.
The
as-prepared
CDs
possess
superior
properties,
such
as
low-cost
facile
synthesis,
good
water
dispersibility,
surface
groups
for
further
modifications,
prominent
photostability,
excellent
compatibility,
rapid/convenient/wash-free
staining
procedures.
Besides,
compared
with
SYTO
RNASelect
(a
commonly
used
commercial
dye
imaging)
that
can
only
image
in
fixed
cells,
realize
high-quality
imaging
not
cells
but
also
living
allowing
real-time
nucleolus-related
biological
behaviors.
Furthermore,
after
conjugating
protoporphyrin
IX
(PpIX),
photosensitizer,
resultant
CD-PpIX
nanomissiles
showed
remarkably
increased
cellular
uptake
nucleus-targeting
properties
achieved
greatly
enhanced
phototherapeutic
efficiency
because
nuclei
show
poor
tolerance
reactive
oxygen
species
produced
during
therapy.
vivo
experiments
revealed
negatively
charged
could
rapidly
specifically
tumor
site
intravenous
injection
cause
efficient
ablation
no
toxic
side
effects
laser
irradiation.
It
is
believed
present
CD-based
nanosystem
will
hold
great
potential
drug
delivery
cancer
Journal of the American Chemical Society,
Journal Year:
2018,
Volume and Issue:
140(30), P. 9566 - 9573
Published: July 11, 2018
The
endoplasmic
reticulum
(ER)
is
responsible
for
the
synthesis
and
folding
of
a
large
number
proteins,
as
well
intracellular
calcium
regulation,
lipid
synthesis,
transfer
to
other
organelles,
emerging
target
cancer
therapy.
However,
strategies
selectively
targeting
ER
cells
are
limited.
Here
we
show
that
enzymatically
generated
crescent-shaped
supramolecular
assemblies
short
peptides
disrupt
cell
membranes
selective
death.
As
revealed
by
sedimentation
assay,
interact
with
synthetic
membranes.
Live
imaging
confirms
impair
membrane
integrity,
which
further
supported
lactate
dehydrogenase
(LDH)
assays.
According
transmission
electron
microscopy
(TEM),
static
light
scattering
(SLS),
critical
micelle
concentration
(CMC),
attaching
an
l-amino
acid
at
C-terminal
d-tripeptide
results
in
assemblies.
Structure-activity
relationship
suggests
morphology
interacting
controlling
fate.
Moreover,
fluorescent
indicates
accumulate
on
ER.
Time-dependent
Western
blot
ELISA
indicate
accumulation
causes
stress
subsequently
activates
caspase
signaling
cascade
approach
situ
generating
binding
scaffolds
(i.e.,
assemblies),
this
work
promises
new
way
developing
anticancer
therapeutics.
ACS Applied Materials & Interfaces,
Journal Year:
2019,
Volume and Issue:
11(30), P. 26529 - 26558
Published: May 28, 2019
The
ultimate
goal
of
cancer
therapy
is
to
eliminate
malignant
tumors
while
causing
no
damage
normal
tissues.
In
the
past
decades,
numerous
nanoagents
have
been
employed
for
treatment
because
their
unique
properties
over
traditional
molecular
drugs.
However,
lack
selectivity
and
unwanted
therapeutic
outcomes
severely
limited
index
nanodrugs.
Recently,
a
series
nanomaterials
that
can
accumulate
in
specific
organelles
(nucleus,
mitochondrion,
endoplasmic
reticulum,
lysosome,
Golgi
apparatus)
within
cells
received
increasing
interest.
These
rationally
designed
either
directly
destroy
subcellular
structures
or
effectively
deliver
drugs
into
proper
targets,
which
further
activate
certain
cell
death
pathways,
enabling
them
boost
efficiency,
lower
drug
dosage,
reduce
side
effects,
avoid
multidrug
resistance,
prevent
recurrence.
this
Review,
design
principles,
targeting
strategies,
mechanisms,
current
challenges,
potential
future
directions
organelle-targeted
will
be
introduced.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
32(27)
Published: Oct. 30, 2019
Engineered
nanomaterials
have
been
extensively
employed
as
therapeutics
for
tumor
management.
Meanwhile,
the
complex
niche
along
with
multiple
barriers
at
cellular
level
collectively
hinders
action
of
nanomedicines.
Here,
advanced
strategies
that
hold
promise
overcoming
numerous
biological
facing
nanomedicines
are
summarized.
Starting
from
entry,
methods
promote
tissue
penetration
nanomedicine
and
address
hypoxia
issue
also
highlighted.
Then,
emphasis
is
given
to
significance
both
physical
barriers,
such
membrane-associated
efflux
pumps,
features,
resistance
apoptosis.
The
pros
cons
an
individual
approach
presented.
In
addition,
associated
technical
problems
discussed,
importance
balancing
therapeutic
merits
additional
cost
sophisticated
designs.
Small,
Journal Year:
2021,
Volume and Issue:
17(52)
Published: Aug. 3, 2021
The
antitumor
efficiency
and
clinical
translation
of
traditional
nanomedicines
is
mainly
restricted
by
low
drug
loading,
complex
preparation
technology,
potential
toxicity
caused
the
overused
carrier
materials.
In
recent
decades,
small-molecule
prodrug
nanoassemblies
(SMP-NAs),
which
are
formed
self-assembly
prodrugs
themselves,
have
been
widely
investigated
with
distinct
advantages
ultrahigh
drug-loading
negligible
excipients-trigged
adverse
reaction.
Benefited
from
simple
process,
SMP-NAs
used
for
chemotherapy,
phototherapy,
immunotherapy,
tumor
diagnosis.
addition,
combination
therapy
based
on
accurate
co-delivery
behavior
can
effectively
address
challenges
heterogeneity
multidrug
resistance.
Recent
trends
in
outlined,
corresponding
mechanisms
discussed
detail.
Besides,
smart
stimuli-responsive
summarized,
special
emphasis
structure-function
relationships.
Finally,
outlooks
cancer
highlighted.
