Engineering precision nanoparticles for drug delivery

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 20(2), P. 101 - 124

Published: Dec. 4, 2020

Language: Английский

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Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(21), P. 13454 - 13619

Published: Sept. 28, 2021

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.

Language: Английский

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Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)

Published: June 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Language: Английский

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Photodynamic Therapy—Current Limitations and Novel Approaches

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: June 10, 2021

Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via excitation a photosensitizer, so that target tumor cells can be destroyed. PDT applied in settings several malignant diseases. In fact, earliest preclinical applications date back to 1900’s. Dougherty reported treatment skin tumors by 1978. Several further studies around 1980 demonstrated effectiveness PDT. Thus, technique has attracted attention numerous researchers since then. Hematoporphyrin derivative received FDA approval as clinical application 1995. We have indeed witnessed considerable progress field over last century. Given fact favorable adverse event profile and enhance anti-tumor immune responses well demonstrating minimally invasive characteristics, it is disappointing not broadly utilized setting for and/or non-malignant issues still hinder development PDT, such those related with light, tissue oxygenation inherent properties photosensitizers. Various photosensitizers been designed/synthesized order overcome limitations. this Review, we provide general overview mechanisms action terms cancer, including effects system vasculature cell destruction. will also briefly mention The current limitations utilization cancer reviewed, identifying problems associated design/synthesis light might pave way more effective approaches. Furthermore, novel promising approaches improve outcome selectivity, bioengineering, subcellular/organelle targeting, etc. discussed detail, potential pioneering exceptional aim reveal full translation are undoubtedly exciting. A better understanding concepts ( e.g. enhanced, two-stage, fractional PDT) most likely prove very useful pursuing improving strategies.

Language: Английский

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Recent progress in nanomedicine for enhanced cancer chemotherapy

Theranostics, Journal Year: 2021, Volume and Issue: 11(13), P. 6370 - 6392

Published: Jan. 1, 2021

As one of the most important cancer treatment strategies, conventional chemotherapy has substantial side effects and leads easily to failure. Therefore, exploring developing more efficient methods enhance is an urgently problem that must be solved. With development nanotechnology, nanomedicine showed a good application prospect in improving chemotherapy. In this review, we aim present discussion on significant research progress for enhanced First, increased enrichment drugs tumor tissues relying different targeting ligands promoting tissue penetration are summarized. Second, specific subcellular organelle-targeted discussed. Next, combinational strategies reverse multidrug resistance (MDR) improve effective intracellular concentration therapeutics Furthermore, advantages combination therapy emphasized. Finally, discuss major problems facing therapeutic chemotherapy, propose possible future directions field.

Language: Английский

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Nanomedicine in cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Aug. 7, 2023

Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise to multiple undesired side effects. Recent advances nanotechnology, accompanied by our growing understanding of biology and nano-bio interactions, have led development series nanocarriers, which aim improve efficacy while reducing off-target toxicity encapsulated anticancer agents through tumor tissue-, cell-, organelle-specific targeting. However, vast majority nanocarriers do not possess hierarchical targeting capability, their indices often compromised poor accumulation, inefficient cellular internalization, inaccurate subcellular localization. This Review outlines current prospective strategies design organelle-targeted nanomedicines, highlights latest progress technologies can dynamically integrate these three different stages static maximize outcomes. Finally, we briefly discuss challenges future opportunities for clinical translation nanomedicines.

Language: Английский

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Engineered Exosome-Mediated Near-Infrared-II Region V₂C Quantum Dot Delivery for Nucleus-Target Low-Temperature Photothermal Therapy

ACS Nano, Journal Year: 2019, Volume and Issue: unknown

Published: Jan. 25, 2019

The limited penetration depth of photothermal agents (PTAs) active in the NIR-I biowindow and thermoresistance caused by heat shock protein (HSP) significantly limit therapeutic efficiency therapy (PTT). To address problem, we introduce a strategy low-temperature nucleus-targeted PTT NIR-II region achieving effective tumor killing combining vanadium carbide quantum dots (V2C QDs) PTA an engineered exosomes (Ex) vector. small fluorescent V2C QDs with good effect were modified TAT peptides packaged into Ex RGD modification (V2C-TAT@Ex-RGD). resulting nanoparticles (NPs) exhibited biocompatibility, long circulation time, endosomal escape ability, they could target cell enter nucleus to realize advanced destruction efficiency. imaging, photoacoustic imaging (PAI), magnetic resonance (MRI) capability NPs also revealed. provides more possibilities toward successful clinical application PTT.

Language: Английский

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Type I photosensitizers based on phosphindole oxide for photodynamic therapy: apoptosis and autophagy induced by endoplasmic reticulum stress

Chemical Science, Journal Year: 2020, Volume and Issue: 11(13), P. 3405 - 3417

Published: Jan. 1, 2020

Photodynamic therapy (PDT) is considered a pioneering and effective modality for cancer treatment, but it still facing challenges of hypoxic tumors. Recently, Type I PDT, as an strategy to address this issue, has drawn considerable attention. Few reports are available on the capability reactive oxygen species (ROS) generation purely organic photosensitizers (PSs). Herein, we report two new PSs, α-TPA-PIO β-TPA-PIO, from phosphindole oxide-based isomers with efficient ROS abilities. A detailed study photophysical photochemical mechanisms conducted shed light molecular design PSs based mechanism. The in vitro results demonstrate that these can selectively accumulate neutral lipid region, particularly endoplasmic reticulum (ER), cells efficiently induce ER-stress mediated apoptosis autophagy PDT. In vivo models indicate β-TPA-PIO successfully achieves remarkable tumor ablation. ROS-based ER stress triggered by β-TPA-PIO-mediated PDT high potential precursor immunostimulatory effect immunotherapy. This work presents comprehensive protocol I-based highlights significance considering working mechanism optimization treatment protocols.

Language: Английский

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Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(16), P. 9093 - 9098

Published: Feb. 6, 2021

Pyroptosis as a lytic and inflammatory form of cell death is powerful tool to fight against cancer. However, pyroptosis usually activated by chemotherapeutic drugs, which limits its anti-tumor applications due drug resistance severe side effects. Herein, we demonstrate that membrane targeting photosensitizers can induce for cancer ablation with noninvasiveness low A series anchoring (TBD-R PSs) aggregation-induced emission (AIE) characteristics were prepared through conjugation TBD phenyl ring cationic chains. Upon light irradiation, cytotoxic ROS produced in situ, resulting direct damage superior ablation. Detailed study revealed gradually became the dominant pathway along increase TBD-R PSs capability. This offers photo-activated pyroptosis-based intervention strategy

Language: Английский

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Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development

Acta Pharmaceutica Sinica B, Journal Year: 2020, Volume and Issue: 10(8), P. 1382 - 1396

Published: Jan. 13, 2020

Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers from undesirable impediment local hypoxia in tumors. Moreover, PDT could further worsen hypoxia. Therefore, developing effective strategies for manipulating improving effectiveness has been focus on antitumor treatment. In this review, mechanism relationship are discussed. we highlight recent trends field nanomedicines modulate enhancing PDT, such as oxygen supply systems, down-regulation consumption utilization. Finally, opportunities challenges put forward facilitate development clinical transformation PDT.

Language: Английский

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