Chemical Science,
Journal Year:
2020,
Volume and Issue:
11(6), P. 1649 - 1656
Published: Jan. 1, 2020
The
extreme
complexity
and
heterogeneity
of
fatal
tumors
requires
the
development
combination
phototherapy
considering
limited
therapeutic
efficiency
conventional
monomodal
photodynamic
therapy
(PDT)
or
photothermal
(PTT).
However,
tumor-specific
drug
administration
accompanying
hypoxia-restrained
PDT
present
main
obstacles
for
executing
an
efficient
phototherapy.
Developing
a
highly
biocompatible,
tumor-specific,
near
infrared
absorbing,
oxygen
(O2)-evolving
multifunctional
nanoplatform
is
thus
crucial
effective
PDT-based
therapy.
In
this
contribution,
ZIF-8-gated
polydopamine
nanoparticle
(PDA)
carrier
was
synthesized
simultaneously
delivering
photosensitizer
catalase
(CAT)
into
tumor
cells,
realizing
cooperatively
enhanced
therapy,
as
systematically
demonstrated
in
vitro
vivo.
ZIF-8
gatekeeper
facilitates
simultaneous
delivery
these
functional
payloads,
subsequent
acidic
pH-stimulated
release.
This
leads
to
significant
improvement
efficacy
by
ameliorating
hypoxic
conditions
since
CAT-mediated
self-sufficient
O2
generation
could
substantially
promote
operation.
addition,
can
effectively
convert
photoradiation
heat,
resulting
thermally
induced
elimination
cancerous
cells.
As
intelligent
multi-mode
nanosystem,
inorganic/organic
hybrid
nanosystem
showed
great
potential
accurate
cancer
diagnosis
immediate
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(15), P. 8450 - 8454
Published: Jan. 25, 2021
Understanding
the
complex
interplay
among
gasotransmitters
is
of
great
significance
but
remains
technically
challenging.
In
this
study,
we
present
design
and
synthesis
a
dually
responsive
BOD-NH-SC
reporter
for
probing
dynamic
alternating
existence
NO
H2
S
in
living
cells.
This
designed
can
repeatedly
cycle
S-nitrosation
transnitrosation
reactions
when
successively
treated
with
S,
thus
affording
interchange
NIR
fluorescence
at
645
nm
(NO)
II
936
(H2
S).
light
unique
alternation
between
two
colors,
synthesized
water-soluble
dots
to
visualize
intracellular
dynamics
S.
These
molecular
probes
provide
toolbox
elucidate
interplaying
roles
interaction
networks
various
signal
transduction
pathways.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Feb. 11, 2021
Nitric
oxide
(NO)
is
an
important
signaling
molecule
overexpressed
in
many
diseases,
thus
the
development
of
NO-activatable
probes
vital
significance
for
monitoring
related
diseases.
However,
sensitive
photoacoustic
(PA)
detecting
NO-associated
complicated
diseases
(e.g.,
encephalitis),
have
yet
to
be
developed.
Herein,
we
report
a
NO-activated
PA
probe
vivo
detection
encephalitis
by
tuning
molecular
geometry
and
energy
transformation
processes.
A
strong
donor-acceptor
structure
with
increased
conjugation
can
obtained
after
NO
treatment,
along
active
intramolecular
motion,
significantly
boosting
"turn-on"
near-infrared
property.
The
exhibits
high
specificity
sensitivity
towards
over
interfering
reactive
species.
capable
differentiating
different
severities
spatiotemporal
resolution.
This
work
will
inspire
more
insights
into
high-performing
activatable
advanced
diagnosis
making
full
use
motion
Chemical Science,
Journal Year:
2020,
Volume and Issue:
11(6), P. 1649 - 1656
Published: Jan. 1, 2020
The
extreme
complexity
and
heterogeneity
of
fatal
tumors
requires
the
development
combination
phototherapy
considering
limited
therapeutic
efficiency
conventional
monomodal
photodynamic
therapy
(PDT)
or
photothermal
(PTT).
However,
tumor-specific
drug
administration
accompanying
hypoxia-restrained
PDT
present
main
obstacles
for
executing
an
efficient
phototherapy.
Developing
a
highly
biocompatible,
tumor-specific,
near
infrared
absorbing,
oxygen
(O2)-evolving
multifunctional
nanoplatform
is
thus
crucial
effective
PDT-based
therapy.
In
this
contribution,
ZIF-8-gated
polydopamine
nanoparticle
(PDA)
carrier
was
synthesized
simultaneously
delivering
photosensitizer
catalase
(CAT)
into
tumor
cells,
realizing
cooperatively
enhanced
therapy,
as
systematically
demonstrated
in
vitro
vivo.
ZIF-8
gatekeeper
facilitates
simultaneous
delivery
these
functional
payloads,
subsequent
acidic
pH-stimulated
release.
This
leads
to
significant
improvement
efficacy
by
ameliorating
hypoxic
conditions
since
CAT-mediated
self-sufficient
O2
generation
could
substantially
promote
operation.
addition,
can
effectively
convert
photoradiation
heat,
resulting
thermally
induced
elimination
cancerous
cells.
As
intelligent
multi-mode
nanosystem,
inorganic/organic
hybrid
nanosystem
showed
great
potential
accurate
cancer
diagnosis
immediate
