Biosensors,
Journal Year:
2024,
Volume and Issue:
14(6), P. 282 - 282
Published: May 30, 2024
Second
near-infrared
(NIR-II)
fluorescence
imaging
is
the
most
advanced
fidelity
method
with
extraordinary
penetration
depth,
signal-to-background
ratio,
biocompatibility,
and
targeting
ability.
It
currently
booming
in
medical
realm
to
diagnose
tumors
being
widely
applied
for
fluorescence-imaging-guided
tumor
surgery.
To
efficiently
execute
this
modern
modality,
scientists
have
designed
various
probes
capable
of
showing
NIR-II
window.
Here,
we
update
state-of-the-art
fluorescent
recent
literature,
including
indocyanine
green,
emissive
cyanine
dyes,
BODIPY
probes,
aggregation-induced
emission
fluorophores,
conjugated
polymers,
donor-acceptor-donor
carbon
nanotubes,
quantum
dots
imaging-guided
Furthermore,
point
out
that
new
materials
NIR-III
higher
wavelength
range
further
optimize
results
are
a
challenge
scientific
world.
In
general,
hope
review
will
serve
as
handbook
researchers
students
who
an
interest
developing
applying
surgery
it
expedite
clinical
translation
from
bench
bedside.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(1), P. 209 - 268
Published: Oct. 19, 2021
In
vivo
imaging
in
the
second
near-infrared
window
(NIR-II,
1000-1700
nm),
which
enables
us
to
look
deeply
into
living
subjects,
is
producing
marvelous
opportunities
for
biomedical
research
and
clinical
applications.
Very
recently,
there
has
been
an
upsurge
of
interdisciplinary
studies
focusing
on
developing
versatile
types
inorganic/organic
fluorophores
that
can
be
used
noninvasive
NIR-IIa/IIb
(NIR-IIa,
1300-1400
nm;
NIR-IIb,
1500-1700
nm)
with
near-zero
tissue
autofluorescence
deeper
penetration.
This
review
provides
overview
reports
published
date
design,
properties,
molecular
imaging,
theranostics
fluorophores.
First,
we
summarize
design
concepts
up-to-date
functional
biomaterials,
order
single-walled
carbon
nanotubes
(SWCNTs),
quantum
dots
(QDs),
rare-earth-doped
nanoparticles
(RENPs),
organic
(OFs).
Then,
these
novel
modalities
applications
brought
by
superior
fluorescent
properties
are
reviewed.
Finally,
challenges
perspectives
future
translation,
aiming
at
boosting
application
progress
NIR-IIa
NIR-IIb
technology
highlighted.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: April 22, 2021
Abstract
J-aggregation
is
an
efficient
strategy
for
the
development
of
fluorescent
imaging
agents
in
second
near-infrared
window.
However,
design
J-aggregates
challenging
due
to
lack
suitable
dyes.
Herein,
we
report
meso
-[2.2]paracyclophanyl-3,5-bis-
N
,
-dimethylaminostyrl
BODIPY
(PCP-BDP2)
as
example
dye
with
induced
fluorescence.
PCP-BDP2
shows
emission
maximum
at
1010
nm
state.
Mechanism
studies
reveal
that
steric
and
conjugation
effect
PCP
group
on
play
key
roles
behavior
photophysical
properties
tuning.
Notably,
can
be
utilized
lymph
node
fluorescence-guided
surgery
nude
mouse,
which
demonstrates
their
potential
clinical
application.
This
study
alternate
platform
developing
agents.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
61(14)
Published: Dec. 7, 2021
Abstract
Optical
imaging,
especially
fluorescence
and
photoacoustic
is
a
non‐invasive
imaging
approach
with
high
spatial
temporal
resolution
sensitivity,
compared
to
positron
emission
tomography
(PET)
or
magnetic
resonance
(MRI).
Due
the
merits
of
using
second
near‐infrared
(NIR‐II)
window,
like
deeper
penetration
depth,
signal‐to‐noise
ratio,
resolution,
low
tissue
damage,
researchers
have
devoted
great
effort
developing
contrast
agents
NIR‐II
absorption
emission.
In
this
Review,
we
summarize
recently
developed
organic
luminescent
materials,
ranging
from
small
molecules
conjugated
polymers.
Then,
systematically
introduce
engineering
strategies
describe
performance
classified
by
skeleton
cores.
Finally,
elucidate
challenges
prospects
these
dyes
for
potential
clinical
applications.
We
expect
our
summary
can
inspire
expand
spectrum
diverse
bioapplications.
Small,
Journal Year:
2021,
Volume and Issue:
17(42)
Published: Aug. 4, 2021
Abstract
Sonodynamic
therapy
(SDT)
is
a
novel
noninvasive
therapeutic
modality
that
combines
low‐intensity
ultrasound
and
sonosensitizers.
Versus
photo‐mediated
therapy,
SDT
has
the
advantages
of
deeper
tissue
penetration,
high
accuracy,
less
side
effects.
Sonosensitizers
are
critical
for
efficacy
during
organic
sonosensitizers
important
because
their
clear
structure,
easy
monitoring,
evaluation
drug
metabolism,
clinical
transformation.
Notably,
nanotechnology
can
be
used
in
field
to
overcome
inherent
obstacles
achieve
sustainable
innovation.
This
review
introduces
small
molecule
sonosensitizers,
nano
translation
by
providing
ideas
references
design
so
as
promote
its
transformation
applications
future.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Oct. 15, 2022
Abstract
Advances
in
diagnostic
imaging
have
provided
unprecedented
opportunities
to
detect
diseases
at
early
stages
and
with
high
reliability.
Diagnostic
is
also
crucial
monitoring
the
progress
or
remission
of
disease
thus
often
central
basis
therapeutic
decision-making.
Currently,
several
modalities
(computed
tomography,
magnetic
resonance
imaging,
positron
emission
among
others)
are
routinely
used
clinics
present
their
own
advantages
limitations.
In
vivo
near-infrared
(NIR)
fluorescence
has
recently
emerged
as
an
attractive
modality
combining
low
cost,
sensitivity,
relative
safety.
As
a
preclinical
tool,
it
can
be
investigate
mechanisms
for
testing
novel
diagnostics
therapeutics
prior
clinical
use.
However,
limited
depth
tissue
penetration
major
challenge
efficient
Therefore,
current
use
few
applications
such
image-guided
surgery
on
tumors
retinal
angiography,
using
FDA-approved
dyes.
Progress
fluorophore
development
NIR
technologies
holds
promise
extend
application
oncology,
cardiovascular
diseases,
plastic
surgery,
brain
others.
Nanotechnology
expected
revolutionize
through
targeted
delivery
fluorescent
probes
antibody
conjugation.
this
review,
we
discuss
latest
advances
technologies,
probes,
future
applications.
Graphical
The Innovation,
Journal Year:
2021,
Volume and Issue:
2(1), P. 100082 - 100082
Published: Jan. 19, 2021
Phototheranostics
integrates
deep-tissue
imaging
with
phototherapy
(containing
photothermal
therapy
and
photodynamic
therapy),
holding
great
promise
in
early
diagnosis
precision
treatment
of
cancers.
Recently,
second
near-infrared
(NIR-II)
fluorescence
exhibits
the
merits
high
accuracy
specificity,
as
well
real-time
detection.
Among
NIR-II
fluorophores,
organic
small
molecular
fluorophores
have
shown
superior
properties
biocompatibility,
variable
structure,
tunable
emission
wavelength
than
inorganic
materials.
What's
more,
some
also
display
excellent
cytotoxicity
when
illuminated
NIR
laser.
This
review
summarizes
progress
different
central
cores
for
cancer
phototheranostics
past
few
years,
focusing
on
structures
phototheranostic
performances.
Furthermore,
challenges
prospects
future
development
toward
clinical
translation
are
discussed.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(51), P. 23668 - 23676
Published: Dec. 13, 2022
The
second
near-infrared
(NIR-II,
1000–1700
nm)
fluorescent
probes
have
significant
advantages
over
visible
or
NIR-I
(600–900
imaging
for
both
depth
of
penetration
and
level
resolution.
Since
the
blood–brain
barrier
(BBB)
prevents
most
molecules
from
entering
central
nervous
system,
NIR-II
dyes
with
large
molecular
frameworks
limited
applications
brain
imaging.
In
this
work,
we
developed
a
series
boron
difluoride
(BF2)
formazanate
dyes,
which
had
tunable
photophysical
properties,
ultrahigh
photostability,
excellent
biological
stability,
strong
brightness.
Modulation
aniline
moiety
BF2
significantly
enhances
their
abilities
to
cross
BBB
noninvasive
Furthermore,
intact
mouse
dynamic
dye
diffusion
across
were
monitored
using
these
in
region.
murine
glioblastoma
models,
can
differentiate
tumors
normal
tissues.
We
anticipate
that
new
type
small
molecule
will
find
potential
creating
drugs
relevant
theranostic
pathologies.
