Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(21)
Published: March 5, 2021
Abstract
Immunotherapy
has
revolutionized
oncology
remarkably
and
gained
great
improvements
in
cancer
therapy.
However,
tumor
immunotherapy
still
encounters
serious
challenges,
especially
certain
tumors
barely
respond
to
immunotherapy.
The
lack
of
immunogenicity
subsequent
insufficient
antitumor
immune
activation
is
a
pivotal
reason.
Here,
general
introduction
the
strengthening
strategies
for
enhanced
are
reviewed.
Specifically,
nanotechnology
nowadays
playing
important
roles
increasing
efficacy
various
treatments,
including
This
review
highlights
how
nanomedicines
integrating
one
or
more
anticancer
therapeutic
methods
(e.g.,
vaccines,
chemotherapy,
phototherapy,
radiotherapy)
increase
rousing
T
cell
related
responses
achieving
inspiring
efficacy.
Given
sophisticated
evasion
mechanisms,
rational
designed
nanodrugs
with
combinational
formulations
summarized
improve
synergistic
ways.
Nanoplatforms
taking
advantage
distinct
features
tissue
stimuli‐responsiveness
targeting
functions
introduced
accelerate
accumulation
drugs
successfully
greatly
promote
low‐dose
administration
programmed
drug
release.
Finally,
challenges
personal
perspectives
concluded.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 5519 - 5603
Published: Jan. 6, 2022
Impurity
doping
is
a
promising
method
to
impart
new
properties
various
materials.
Due
their
unique
optical,
magnetic,
and
electrical
properties,
rare-earth
ions
have
been
extensively
explored
as
active
dopants
in
inorganic
crystal
lattices
since
the
18th
century.
Rare-earth
can
alter
crystallographic
phase,
morphology,
size,
leading
tunable
optical
responses
of
doped
nanomaterials.
Moreover,
control
ultimate
electronic
catalytic
performance
nanomaterials
scalable
manner,
enabling
significant
improvements
energy
harvesting
conversion.
A
better
understanding
critical
role
prerequisite
for
development
an
extensive
repertoire
functional
practical
applications.
In
this
review,
we
highlight
recent
advances
associated
applications
many
fields.
This
review
covers
key
criteria
doping,
including
basic
structures,
lattice
environments,
strategies,
well
fundamental
design
principles
that
enhance
electrical,
catalytic,
magnetic
material.
We
also
discuss
future
research
directions
challenges
controlling
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(8), P. 5086 - 5125
Published: Jan. 1, 2021
Some
infectious
or
malignant
diseases
such
as
cancers
are
seriously
threatening
the
health
of
human
beings
all
over
world.
The
commonly
used
antibiotic
therapy
cannot
effectively
treat
these
within
a
short
time,
and
also
bring
about
adverse
effects
drug
resistance
immune
system
damage
during
long-term
systemic
treatment.
Phototherapy
is
an
emerging
antibiotic-free
strategy
to
diseases.
Upon
light
irradiation,
phototherapeutic
agents
can
generate
cytotoxic
reactive
oxygen
species
(ROS)
induce
temperature
increase,
which
leads
death
targeted
cells.
These
two
kinds
killing
strategies
referred
photodynamic
(PDT)
photothermal
(PTT),
respectively.
So
far,
many
photo-responsive
have
been
developed.
Among
them,
metal-organic
framework
(MOF)
becoming
one
most
promising
materials
because
its
structure
chemical
compositions
be
easily
modulated
achieve
specific
functions.
MOFs
intrinsic
ability
under
rational
design
MOF
construction,
serve
carrier
therapeutic
agents,
owing
tunable
porosity.
provide
feasibility
for
various
combined
therapies
targeting
methods,
improves
efficiency
phototherapy.
In
this
review,
we
firstly
investigated
principles
phototherapy,
comprehensively
summarized
recent
advances
in
PDT,
PTT
synergistic
therapy,
from
construction
modification.
We
expect
that
our
demonstration
will
shed
on
future
development
field,
it
step
closer
clinical
trials.
Theranostics,
Journal Year:
2021,
Volume and Issue:
11(13), P. 6370 - 6392
Published: Jan. 1, 2021
As
one
of
the
most
important
cancer
treatment
strategies,
conventional
chemotherapy
has
substantial
side
effects
and
leads
easily
to
failure.
Therefore,
exploring
developing
more
efficient
methods
enhance
is
an
urgently
problem
that
must
be
solved.
With
development
nanotechnology,
nanomedicine
showed
a
good
application
prospect
in
improving
chemotherapy.
In
this
review,
we
aim
present
discussion
on
significant
research
progress
for
enhanced
First,
increased
enrichment
drugs
tumor
tissues
relying
different
targeting
ligands
promoting
tissue
penetration
are
summarized.
Second,
specific
subcellular
organelle-targeted
discussed.
Next,
combinational
strategies
reverse
multidrug
resistance
(MDR)
improve
effective
intracellular
concentration
therapeutics
Furthermore,
advantages
combination
therapy
emphasized.
Finally,
discuss
major
problems
facing
therapeutic
chemotherapy,
propose
possible
future
directions
field.
Theranostics,
Journal Year:
2021,
Volume and Issue:
12(1), P. 434 - 458
Published: Dec. 15, 2021
Cancer
immunotherapy
has
made
tremendous
clinical
progress
in
advanced-stage
malignancies.
However,
patients
with
various
tumors
exhibit
a
low
response
rate
to
because
of
powerful
immunosuppressive
tumor
microenvironment
(TME)
and
insufficient
immunogenicity
tumors.
Photodynamic
therapy
(PDT)
can
not
only
directly
kill
cells,
but
also
elicit
immunogenic
cell
death
(ICD),
providing
antitumor
immunity.
Unfortunately,
limitations
from
the
inherent
nature
complex
TME
significantly
reduce
efficiency
PDT.
Recently,
smart
nanomedicine-based
strategies
could
subtly
modulate
pharmacokinetics
therapeutic
compounds
optimize
both
PDT
immunotherapy,
resulting
an
improved
effect.
Here,
emerging
nanomedicines
for
PDT-driven
cancer
are
reviewed,
including
hypoxia-reversed
nanomedicines,
nanosized
metal-organic
frameworks,
subcellular
targeted
nanoparticles
(NPs).
Moreover,
we
highlight
synergistic
nanotherapeutics
used
amplify
immune
responses
combined
against
Lastly,
challenges
future
expectations
field
discussed.
Nano-Micro Letters,
Journal Year:
2020,
Volume and Issue:
12(1)
Published: July 5, 2020
Abstract
Although
notable
progress
has
been
made
on
novel
cancer
treatments,
the
overall
survival
rate
and
therapeutic
effects
are
still
unsatisfactory
for
patients.
Chemoimmunotherapy,
combining
chemotherapeutics
immunotherapeutic
drugs,
emerged
as
a
promising
approach
treatment,
with
advantages
of
cooperating
two
kinds
treatment
mechanism,
reducing
dosage
drug
enhancing
effect.
Moreover,
nano-based
delivery
system
(NDDS)
was
applied
to
encapsulate
chemotherapeutic
agents
exhibited
outstanding
properties
such
targeted
delivery,
tumor
microenvironment
response
site-specific
release.
Several
nanocarriers
have
approved
in
clinical
chemotherapy
showed
significant
improvement
efficiency
compared
traditional
formulations,
liposomes
(Doxil
®
,
Lipusu
),
nanoparticles
(Abraxane
)
micelles
(Genexol-PM
).
The
applications
NDDS
chemoimmunotherapy
would
be
powerful
strategy
future
which
could
greatly
enhance
efficacy,
reduce
side
optimize
outcomes
Herein,
current
approaches
immunotherapy
were
discussed,
recent
advances
further
reviewed.
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Sept. 12, 2022
Poor
targeting
of
therapeutics
leading
to
severe
adverse
effects
on
normal
tissues
is
considered
one
the
obstacles
in
cancer
therapy.
To
help
overcome
this,
nanoscale
drug
delivery
systems
have
provided
an
alternative
avenue
for
improving
therapeutic
potential
various
agents
and
bioactive
molecules
through
enhanced
permeability
retention
(EPR)
effect.
Nanosystems
with
cancer-targeted
ligands
can
achieve
effective
tumor
cells
utilizing
cell
surface-specific
receptors,
vasculature
antigens
high
accuracy
affinity.
Additionally,
stimuli-responsive
nanoplatforms
also
been
as
a
promising
strategy
against
tumors,
these
maintain
their
stealth
feature
under
conditions,
but
upon
homing
cancerous
lesions
or
microenvironment,
are
responsive
release
cargoes.
In
this
review,
we
comprehensively
summarize
field
active
number
studies
context
emerging
nanoplatform
development,
discuss
how
knowledge
contribute
further
improvements
clinical
practice.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(49)
Published: Sept. 9, 2020
Light
is
a
particularly
appealing
tool
for
on-demand
drug
delivery
due
to
its
noninvasive
nature,
ease
of
application
and
exquisite
temporal
spatial
control.
Great
progress
has
been
achieved
in
the
development
novel
light-driven
strategies
with
both
breadth
depth.
Light-controlled
platforms
can
be
generally
categorized
into
three
groups:
photochemical,
photothermal,
photoisomerization-mediated
therapies.
Various
advanced
materials,
such
as
metal
nanoparticles,
sulfides
oxides,
metal-organic
frameworks,
carbon
nanomaterials,
upconversion
semiconductor
stimuli-responsive
micelles,
polymer-
liposome-based
nanoparticles
have
applied
light-stimulated
delivery.
In
view
increasing
interest
targeted
delivery,
we
review
light-responsive
systems
focus
on
recent
advances,
key
limitations,
future
directions.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
60(23), P. 12682 - 12705
Published: July 16, 2020
Immunotherapy
that
harnesses
the
power
of
immune
system
to
eliminate
malignant
cells
has
offered
an
effective
approach
for
cancer
treatment.
However,
limited
patient
response
rates
and
potential
immune-related
adverse
events
exist
as
two
major
issues
immunotherapy.
In
parallel,
a
variety
electromagnetic
nanomaterials
generate
heat
and/or
reactive
oxygen
species
triggered
by
energy
have
been
applied
magnetic
hyperthermia
therapy,
sonodynamic
photothermal
photodynamic
radiotherapy,
which
ability
induce
immunogenic
cell
death.
This
review
summarizes
recent
development
nanomedicines
in
combinational
The
mechanisms
reprogramming
immunosuppressive
tumor
microenvironment
sensitizing
tumors
immunotherapy
are
highlighted.
Furthermore,
challenges
perspectives
discussed.
