Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(21)
Published: March 5, 2021
Abstract
Immunotherapy
has
revolutionized
oncology
remarkably
and
gained
great
improvements
in
cancer
therapy.
However,
tumor
immunotherapy
still
encounters
serious
challenges,
especially
certain
tumors
barely
respond
to
immunotherapy.
The
lack
of
immunogenicity
subsequent
insufficient
antitumor
immune
activation
is
a
pivotal
reason.
Here,
general
introduction
the
strengthening
strategies
for
enhanced
are
reviewed.
Specifically,
nanotechnology
nowadays
playing
important
roles
increasing
efficacy
various
treatments,
including
This
review
highlights
how
nanomedicines
integrating
one
or
more
anticancer
therapeutic
methods
(e.g.,
vaccines,
chemotherapy,
phototherapy,
radiotherapy)
increase
rousing
T
cell
related
responses
achieving
inspiring
efficacy.
Given
sophisticated
evasion
mechanisms,
rational
designed
nanodrugs
with
combinational
formulations
summarized
improve
synergistic
ways.
Nanoplatforms
taking
advantage
distinct
features
tissue
stimuli‐responsiveness
targeting
functions
introduced
accelerate
accumulation
drugs
successfully
greatly
promote
low‐dose
administration
programmed
drug
release.
Finally,
challenges
personal
perspectives
concluded.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(3), P. 585 - 585
Published: Jan. 18, 2023
Although
we
have
made
great
strides
in
treating
deadly
diseases
over
the
years,
cancer
therapy
still
remains
a
daunting
challenge.
Among
numerous
anticancer
methods,
photodynamic
(PDT),
non-invasive
therapeutic
approach,
has
attracted
much
attention.
PDT
exhibits
outstanding
performance
therapy,
but
some
unavoidable
disadvantages,
including
limited
light
penetration
depth,
poor
tumor
selectivity,
as
well
oxygen
dependence,
largely
limit
its
efficiency
for
solid
tumors
treatment.
Thus,
strategies
gone
into
overcoming
these
obstacles,
such
exploring
new
photosensitizers
with
higher
conversion
efficiency,
alleviating
hypoxia
to
fuel
generation
of
reactive
species
(ROS),
designing
tumor-targeted
PS,
and
applying
PDT-based
combination
strategies.
In
this
review,
briefly
summarized
related
approaches,
which
are
mainly
characterized
by
advanced
PSs,
PSs
excellent
additional
refreshing
features.
We
also
summarize
therapies
effects.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(7), P. 12086 - 12098
Published: June 24, 2021
Immune
checkpoint
blockade
is
a
promising
approach
for
cancer
immunotherapy,
but
many
patients
do
not
respond
due
to
the
immunosuppressive
tumor
microenvironment
(ITM).
Herein,
we
propose
visible-light-triggered
prodrug
nanoparticles
(LT-NPs)
reversing
ITM
into
high
immunogenic
tumors
potentiate
immunotherapy.
The
photosensitizer
(verteporfin;
VPF),
cathepin
B-specific
cleavable
peptide
(FRRG),
and
doxorubicin
(DOX)
conjugates
are
self-assembled
LT-NPs
without
any
additional
carrier
material.
specifically
cleaved
VPF
DOX
in
cathepsin
B-overexpressing
cells,
thereby
inducing
cancer-specific
cytotoxicity
cell
death
(ICD)
upon
visible
light
irradiation.
In
models,
highly
accumulate
within
via
enhanced
permeability
retention
effect,
photochemotherapy
of
induces
effective
ICD
maturation
dendritic
cells
stimulate
cross-presentation
cancer-antigens
T
cells.
Furthermore,
with
PD-L1
greatly
inhibit
growth,
recurrence,
lung
metastasis
by
initiating
strong
antitumor
immune
response.
provides
strategy
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(21)
Published: March 5, 2021
Abstract
Immunotherapy
has
revolutionized
oncology
remarkably
and
gained
great
improvements
in
cancer
therapy.
However,
tumor
immunotherapy
still
encounters
serious
challenges,
especially
certain
tumors
barely
respond
to
immunotherapy.
The
lack
of
immunogenicity
subsequent
insufficient
antitumor
immune
activation
is
a
pivotal
reason.
Here,
general
introduction
the
strengthening
strategies
for
enhanced
are
reviewed.
Specifically,
nanotechnology
nowadays
playing
important
roles
increasing
efficacy
various
treatments,
including
This
review
highlights
how
nanomedicines
integrating
one
or
more
anticancer
therapeutic
methods
(e.g.,
vaccines,
chemotherapy,
phototherapy,
radiotherapy)
increase
rousing
T
cell
related
responses
achieving
inspiring
efficacy.
Given
sophisticated
evasion
mechanisms,
rational
designed
nanodrugs
with
combinational
formulations
summarized
improve
synergistic
ways.
Nanoplatforms
taking
advantage
distinct
features
tissue
stimuli‐responsiveness
targeting
functions
introduced
accelerate
accumulation
drugs
successfully
greatly
promote
low‐dose
administration
programmed
drug
release.
Finally,
challenges
personal
perspectives
concluded.
