MOF‐Coated Upconversion Nanoparticle Agents Enable Synergistic Photodynamic Therapy and Immunotherapy DOI

Jiarui Du,

Jia Tao, Feng Li

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Abstract Although conventional therapeutic approaches demonstrate significant success in treating primary tumors, their efficacy diminishes when addressing distant and metastatic calling for new technologies to transport activate the agents. Here, a core‐shell UCNP@MOF (upconversion nanoparticle — metal organic framework) nanoagents is constructed Type I II photodynamic therapy under biocompatible near‐infrared light irradiance (at 808 nm) utilize pore loading capacity further realize synergistic immunotherapy solid tumors. The Cu 2+ + reduction at nodes MOFs shell demonstrated promote generation of reactive oxygen species via depletion overexpressed glutathione (GSH) compounds, while tumor microenvironment‐enriched hydrogen peroxide found substantially augment PDT effects. Importantly, pore‐loaded indoleamine 2,3‐dioxygenase (IDO) inhibitor, along with s‐nitroso‐n‐acetylpenicillamine (SNAP), upregulated tumor‐infiltrating lymphocytes induced prominent immunotherapeutic effects vivo. This have effectiveness against both tumors xenografted models, holding promise metastasis.

Language: Английский

Cellulose–metal organic frameworks (CelloMOFs) hybrid materials and their multifaceted Applications: A review DOI Creative Commons
Hani Nasser Abdelhamid, Aji P. Mathew

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 451, P. 214263 - 214263

Published: Oct. 22, 2021

Cellulose–MOFs (CelloMOFs) are attractive hybrid materials that make available a range of hitherto unattainable properties by conjugating cellulosic with metal–organic frameworks (MOFs). CelloMOFs have demonstrated great potential to be applied in several fields such as water remediation, air purification, gas storage, sensing/biosensing, and biomedicine. can act an efficient adsorbent remove emerging contaminants metals, dyes, drugs, antibiotics, pesticides, oils via adsorption. They also used catalysts for catalytic degradation, reduction, oxidation organic pollutants. been filters purification removing greenhouse gases carbon dioxide (CO2), volatile compounds (VOCs), particulate matter (PMs). Biomedical applications antibacterial, drug delivery, biosensing were reported materials. This review summarized the synthesis, characterization, cellulose-MOFs It covered broad overview status combination cellulose micron nanoscale MOFs. At end review, challenges outlook regarding discussed. Hopefully, this will useful guide researchers scientists who looking quick access relevant references about their applications.

Language: Английский

Citations

265
MOF based electrochemical sensors for the detection of physiologically relevant biomolecules: An overview DOI
Miriam Daniel,

Georgeena Mathew,

Masakazu Anpo

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 468, P. 214627 - 214627

Published: June 1, 2022

Language: Английский

Citations

186
Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy DOI Creative Commons
Jie Yang, Dihua Dai, Xi Zhang

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 295 - 323

Published: Dec. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Language: Английский

Citations

139
Recent advances in Zn-MOFs and their derivatives for cancer therapeutic applications DOI Creative Commons
Minmin Li, Zhixin Zhang, Yamei Yu

et al.

Materials Advances, Journal Year: 2023, Volume and Issue: 4(21), P. 5050 - 5093

Published: Jan. 1, 2023

The use of zinc-based MOFs in a variety cancer treatments was comprehensively reviewed. advantages and disadvantages, as well the application prospects future, are also discussed.

Language: Английский

Citations

73
Metalation of metal–organic frameworks: fundamentals and applications DOI

Haiyu Li,

Xiang‐Jing Kong, Song‐De Han

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(11), P. 5626 - 5676

Published: Jan. 1, 2024

Metalation of metal-organic frameworks (MOFs) has been developed as a prominent strategy for materials functionalization pore chemistry modulation and property optimization. By introducing exotic metal ions/complexes/nanoparticles onto/into the parent framework, many metallized MOFs have exhibited significantly improved performance in wide range applications. In this review, we focus on research progress metalation during last five years, spanning design principles, synthetic strategies, potential Based crystal engineering minor change MOF composition through would lead to leveraged variation properties. This review starts from general strategies established incorporation species within MOFs, followed by principles graft desired functionality while maintaining porosity frameworks. Facile contributed great number bespoke with excellent performance, summarize their applications gas adsorption separation, heterogeneous catalysis, detection sensing, energy storage conversion. The underlying mechanisms are also investigated state-of-the-art techniques analyzed gaining insight into structure-property relationships, which turn facilitate further development principles. Finally, current challenges opportunities discussed, promising future directions customizing next-generation advanced outlined well.

Language: Английский

Citations

54
Multifunctional nanoparticle for cancer therapy DOI Creative Commons
Yan Gao, Kaiyu Wang, Jin Zhang

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(1)

Published: Jan. 11, 2023

Cancer is a complex disease associated with combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment diagnosis for cancer, current strategies simultaneously focus on various tumor targets. Based the rapid development nanotechnology, nanocarriers have been shown to exhibit excellent potential cancer therapy. Compared nanoparticles single functions, multifunctional are believed be more aggressive potent context targeting. However, not simply an upgraded version original function, but involves sophisticated system proper backbone, optimized modification sites, simple preparation method, efficient function integration. Despite this, many well-designed promising therapeutic emerged recently. Here, give detailed understanding analyzation currently developed nanoparticles, their platform structures organic or inorganic backbones were systemically generalized. We emphasized functionalization strategies, which additional functions nanoparticle. also discussed application that involved nanoformulations functional crosstalk. This review thus provides overview construction advances nanoparticles.

Language: Английский

Citations

45
A Fluorinated BODIPY-Based Zirconium Metal–Organic Framework for In Vivo Enhanced Photodynamic Therapy DOI Creative Commons
Xu Chen, Bárbara B. Mendes, Yunhui Zhuang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(2), P. 1644 - 1656

Published: Jan. 4, 2024

Photodynamic therapy (PDT), an emergent noninvasive cancer treatment, is largely dependent on the presence of efficient photosensitizers (PSs) and a sufficient oxygen supply. However, therapeutic efficacy PSs greatly compromised by poor solubility, aggregation tendency, depletion within solid tumors during PDT in hypoxic microenvironments. Despite potential PS-based metal–organic frameworks (MOFs), addressing hypoxia remains challenging. Boron dipyrromethene (BODIPY) chromophores, with excellent photostability, have exhibited great bioimaging. their practical application suffers from limited chemical stability under harsh MOF synthesis conditions. Herein, we report first example Zr-based MOF, namely, 69-L2, exclusively constructed BODIPY-derived ligands via single-crystal to post-synthetic exchange, where direct solvothermal method not applicable. To increase performance hypoxia, modify 69-L2 fluorinated phosphate-functionalized methoxy poly(ethylene glycol). The resulting 69-L2@F carrier, enabling tumor oxygenation simultaneously acting as PS for reactive species (ROS) generation LED irradiation. We demonstrate that has enhanced effect triple-negative breast MDA-MB-231 cells both normoxia hypoxia. Following positive results, evaluated vivo activity hydrogel, local mice model achieving exceptional antitumor only 2 days. envision BODIPY-based Zr-MOFs provide solution relief maximize PDT, offering new insights into design promising MOF-based tumors.

Language: Английский

Citations

42
Porphyrin-based metal–organic frameworks for photo(electro)catalytic CO2 reduction DOI

Guixiang Ding,

Chunxue Li, Lihui Chen

et al.

Energy & Environmental Science, Journal Year: 2024, Volume and Issue: 17(15), P. 5311 - 5335

Published: Jan. 1, 2024

The panorama of the latest developments emerging porphyrin-based MOFs for photo(electro)catalytic CO 2 reduction is shown.

Language: Английский

Citations

38
Design of porphyrin-based frameworks for artificial photosynthesis and environmental remediation: Recent progress and future prospects DOI
Rajesh Das, Praveen Kumar Verma, C. M. Nagaraja

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215944 - 215944

Published: May 16, 2024

Language: Английский

Citations

30
2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging DOI

Zhen Hu,

Lili Feng, Piaoping Yang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)

Published: Jan. 4, 2024

Abstract Second near‐infrared (NIR‐II) bioimaging technology shows broad application prospects in the field of biomedical due to its significant superiority deep tissue penetration and high signal‐to‐background ratio. Among them, organic small molecule fluorophores have received progressively more consideration their low biotoxicity, biocompatibility, rapid clearance, good modification properties. As key acceptor core, 2, 1, 3‐benzothiadiazole (BTD) derivative plays an essential role construction donor‐acceptor‐donor type NIR‐II fluorophores. This mini‐review summarizes research development based on BTD derivatives bioimaging, focusing molecular design photophysical properties, introduces a part applications biological field. Furthermore, challenges BTD‐based future are discussed .

Language: Английский

Citations

21