Antibiotics,
Journal Year:
2020,
Volume and Issue:
9(8), P. 455 - 455
Published: July 28, 2020
Oceans
cover
seventy
percent
of
the
planet’s
surface
and
besides
being
an
immense
reservoir
biological
life,
they
serve
as
vital
sources
for
human
sustenance,
tourism,
transport
commerce.
Yet,
it
is
estimated
by
National
Oceanic
Atmospheric
Administration
(NOAA)
that
eighty
oceans
remain
unexplored.
The
untapped
resources
present
in
may
be
fundamental
solving
several
world’s
public
health
crises
21st
century,
which
span
from
rise
antibiotic
resistance
bacteria,
pathogenic
fungi
parasites,
to
cancer
incidence
viral
infection
outbreaks.
In
this
review,
risks
well
how
marine
bacterial
derived
natural
products
tools
fight
them
will
discussed.
Moreover,
overview
made
research
pipeline
novel
molecules,
identification
bioactive
crude
extracts
isolation
chemical
characterization
molecules
within
framework
One
Health
approach.
This
review
highlights
information
has
been
published
since
2014,
showing
current
relevance
bacteria
discovery
products.
Marine Drugs,
Journal Year:
2019,
Volume and Issue:
17(9), P. 491 - 491
Published: Aug. 23, 2019
Cancer
remains
one
of
the
most
lethal
diseases
worldwide.
There
is
an
urgent
need
for
new
drugs
with
novel
modes
action
and
thus
considerable
research
has
been
conducted
anticancer
from
natural
sources,
especially
plants,
microbes
marine
organisms.
Marine
populations
represent
reservoirs
bioactive
metabolites
diverse
groups
chemical
structures.
This
review
highlights
impact
organisms,
particular
emphasis
on
algae,
bacteria,
actinomycetes,
fungi,
sponges
soft
corals.
Anti-cancer
effects
products
in
vitro
vivo
studies
were
first
introduced;
their
activity
prevention
tumor
formation
related
compound-induced
apoptosis
cytotoxicities
tackled.
The
possible
molecular
mechanisms
behind
biological
are
also
presented.
diversity
structures,
property
space.
Finally,
therapeutic
strategies
present
use
marine-derived
components,
its
future
direction
limitations
discussed.
Molecules,
Journal Year:
2020,
Volume and Issue:
25(22), P. 5277 - 5277
Published: Nov. 12, 2020
The
advancements
of
information
technology
and
related
processing
techniques
have
created
a
fertile
base
for
progress
in
many
scientific
fields
industries.
In
the
drug
discovery
development,
machine
learning
been
used
development
novel
candidates.
methods
designing
targets
now
routinely
combine
deep
algorithms
to
enhance
efficiency,
efficacy,
quality
developed
outputs.
generation
incorporation
big
data,
through
technologies
such
as
high-throughput
screening
high
through-put
computational
analysis
databases
both
lead
target
discovery,
has
increased
reliability
incorporated
techniques.
use
these
virtual
encompassing
online
also
highlighted
developing
synthesis
pathways.
this
review,
utilized
associated
will
be
discussed.
applications
that
produce
promising
results
reviewed.
Journal of Natural Products,
Journal Year:
2021,
Volume and Issue:
84(11), P. 2795 - 2807
Published: Oct. 18, 2021
Computational
approaches
such
as
genome
and
metabolome
mining
are
becoming
essential
to
natural
products
(NPs)
research.
Consequently,
a
need
exists
for
an
automated
structure-type
classification
system
handle
the
massive
amounts
of
data
appearing
NP
structures.
An
ideal
semantic
ontology
NPs
should
go
beyond
simple
presence/absence
chemical
substructures,
but
also
include
taxonomy
producing
organism,
nature
biosynthetic
pathway,
and/or
their
biological
properties.
Thus,
holistic
automatic
framework
could
have
considerable
value
comprehensively
navigate
relatedness
NPs,
especially
so
when
analyzing
large
numbers
NPs.
Here,
we
introduce
NPClassifier,
deep-learning
tool
structural
from
counted
Morgan
fingerprints.
NPClassifier
is
expected
accelerate
enhance
discovery
by
linking
structures
underlying
Nucleic Acids Research,
Journal Year:
2021,
Volume and Issue:
50(D1), P. D1317 - D1323
Published: Oct. 4, 2021
Within
the
natural
products
field
there
is
an
increasing
emphasis
on
study
of
compounds
from
microbial
sources.
This
has
been
fuelled
by
interest
in
central
role
that
microorganisms
play
mediating
both
interspecies
interactions
and
host-microbe
relationships.
To
support
chemistry
produced
we
released
Natural
Products
Atlas,
a
database
known
structures,
2019.
paper
reports
release
new
version
which
includes
full
RESTful
application
programming
interface
(API),
website
framework,
expanded
8128
compounds,
bringing
total
to
32
552.
In
addition
these
structural
content
changes
have
added
taxonomic
descriptions
for
all
taxa
chemical
ontology
terms
NP
Classifier
ClassyFire.
We
also
performed
manual
curation
review
entries
with
incomplete
configurational
assignments
integrated
data
external
resources,
including
CyanoMetDB.
Finally,
improved
user
experience
updating
Overview
dashboard
creating
origin.
The
can
be
accessed
via
interactive
at
https://www.npatlas.org.
Natural Product Reports,
Journal Year:
2021,
Volume and Issue:
38(11), P. 1967 - 1993
Published: Jan. 1, 2021
This
review
highlights
the
key
computational
tools
and
emerging
strategies
for
metabolite
annotation,
discusses
how
these
advances
will
enable
integrated
large-scale
analysis
to
accelerate
natural
product
discovery.
