Molecules,
Journal Year:
2023,
Volume and Issue:
28(17), P. 6371 - 6371
Published: Aug. 31, 2023
The
isolation
and
identification
of
an
increasing
number
secondary
metabolites
featuring
unique
skeletons
possessing
diverse
bioactivities
sourced
from
marine
microorganisms
have
garnered
the
interest
numerous
natural
product
chemists.
There
has
been
a
growing
emphasis
on
how
to
cultivate
enhance
chemical
diversity
avoid
rediscovery
known
ones.
Given
significance
as
means
communication
among
microorganisms,
microbial
co-culture
introduced.
By
mimicking
growth
patterns
communities
in
their
habitats,
strategy
is
anticipated
stimulate
biosynthetic
gene
clusters
that
remain
dormant
under
traditional
laboratory
culture
conditions,
thereby
inducing
production
novel
metabolites.
Different
previous
reviews
mainly
focusing
fermentation
conditions
or
metabolite
diversities
marine-derived
co-paired
strains,
this
review
covers
2012
2022,
turns
particular
discussion
highlighting
selection
strains
for
especially
methods
co-cultural
apparatus,
screening
approaches
convenient
rapid
detection
metabolites,
these
are
important
co-culture.
Finally,
structural
bioactivity
molecules
also
discussed.
challenges
prospects
discussed
behave
views
authors.
Food Production Processing and Nutrition,
Journal Year:
2023,
Volume and Issue:
5(1)
Published: March 20, 2023
Abstract
Green
seaweed,
as
the
most
abundant
species
of
macroseaweeds,
is
an
important
marine
biological
resource.
It
a
rich
source
several
amino
acids,
fatty
and
dietary
fibers,
well
polysaccharides,
polyphenols,
pigments,
other
active
substances,
which
have
crucial
roles
in
various
processes
such
antioxidant
activity,
immunoregulation,
anti-inflammatory
response.
In
recent
years,
attention
to
resources
has
accelerated
exploration
utilization
green
seaweeds
for
greater
economic
value.
This
paper
elaborates
on
main
nutrients
substances
present
different
provides
review
their
activities
applications
high-value
utilization.
Graphical
abstract
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
67(4), P. 2602 - 2618
Published: Feb. 1, 2024
To
discover
novel
osteoclast-targeting
antiosteoporosis
leads
from
natural
products,
we
identified
40
tanzawaic
acid
derivatives,
including
22
new
ones
(1–8,
14–19,
27–32,
37,
and
38),
the
South
China
Sea
mangrove-derived
fungus
Penicillium
steckii
SCSIO
41025.
Penicisteck
F
(2),
one
of
derivatives
showing
most
potent
NF-κB
inhibitory
activity,
remarkably
inhibited
osteoclast
generation
in
vitro.
Mechanistically,
2
reduced
RANKL-induced
IκBα
degradation,
p65
nuclear
translocation,
activation
translocation
NFATc1,
relevant
mRNA
expression.
could
be
a
potential
molecular
target
for
2,
which
has
been
further
determined
by
cellular
thermal
shift
assay,
surface
plasmon
resonance,
gene
knock-down
assay.
Moreover,
also
alleviate
osteoporosis
ovariectomized
mice
reducing
quantities
osteoclasts.
Our
finding
offered
inhibitor
osteoclastogenesis
development
agents.
Cell Death Discovery,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 22, 2025
Abstract
Nature
is
an
abundant
and
largely
untapped
source
of
potent
bioactive
molecules.
Ribosome
biogenesis
modulators
have
proven
effective
in
suppressing
cancer
cell
growth
are
currently
being
evaluated
clinical
trials
for
anticancer
therapies.
In
this
study,
we
characterized
the
alkaloid
nitidine
chloride
(NC),
produced
by
endemic
Cameroonian
plant
Fagara
(and
other
plants).
We
demonstrate
that
NC
kills
cells
regardless
their
p53
status
inhibits
tumor
vitro.
Furthermore,
profoundly
suppresses
global
protein
synthesis.
Treatment
human
with
causes
severe
nucleolar
disruption
pre-rRNA
synthesis
destabilizing
key
factors
required
recruitment
RNA
polymerase
I
to
ribosomal
DNA
promoters.
vitro,
intercalates
into
topoisomerases
II.
Consistently,
treatment
activates
a
damage
response.
propose
torsional
stress
on
rDNA
caused
topoisomerase
inhibition
leads
loss
function
shutdown
ribosome
biogenesis.
Although
has
long
been
suspected
possessing
properties,
here
provide
molecular
explanation
its
mechanism
action.
budding
yeast
cells,
interestingly,
growth,
impairs
biogenesis,
disrupts
structure.
This
suggests
mode
action
at
least
partially
evolutionarily
conserved.
Marine Drugs,
Journal Year:
2022,
Volume and Issue:
20(11), P. 701 - 701
Published: Nov. 9, 2022
The
biocontrol
fungus
Trichoderma
harzianum,
from
both
marine
and
terrestrial
environments,
has
attracted
considerable
attention.
T.
harzianum
a
tremendous
potential
to
produce
variety
of
bioactive
secondary
metabolites
(SMs),
which
are
an
important
source
new
herbicides
antibiotics.
This
review
prioritizes
the
SMs
1988
June
2022,
their
relevant
biological
activities.
Marine-derived
SMs,
especially
terpenoids,
polyketides,
macrolides
compounds,
occupy
significant
proportion
natural
products
deserving
more
our
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
197, P. 106968 - 106968
Published: Oct. 20, 2023
The
potential
of
marine
natural
products
as
effective
drugs
for
osteoporosis
treatment
is
an
understudied
area.
In
this
study,
we
investigated
the
ability
lead
compounds
from
deep-sea-derived
Penicillium
solitum
MCCC
3A00215
to
promote
bone
formation
in
vitro
and
vivo.
We
found
that
penicopeptide
A
(PPA)
promoted
osteoblast
mineralization
among
marrow
mesenchymal
stem
cells
(BMSCs)
a
concentration-dependent
manner,
thus,
selected
peptide
further
testing.
Our
experiments
showed
PPA
significantly
osteogenic
differentiation
BMSCs
while
inhibiting
their
adipogenic
not
affecting
chondrogenic
differentiation.
Mechanistic
studies
binds
directly
AKT
GSK-3β
activates
phosphorylation
GSK-3β,
resulting
accumulation
β-catenin.
also
evaluated
therapeutic
female
mouse
model
ovariectomy-induced
systemic
loss.
model,
prevented
decreases
volume
trabecular
thickness.
conclusion,
our
vivo
results
demonstrated
could
osteoblast-related
via
AKT,
β-catenin
signaling
pathways,
indicating
clinical
candidate
compound
prevention.
