Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown
Published: Jan. 1, 2023
Language: Английский
Chemical Science, Journal Year: 2023, Volume and Issue: 14(29), P. 7782 - 7817
Published: Jan. 1, 2023
Peptide and protein selective modification at tyrosine residues has become an exploding field of research as constitutes a robust alternative to lysine cysteine-targeted traditional peptide/protein protocols. This review offers comprehensive summary the latest advances in tyrosine-selective cleavage, functionalization, conjugation peptides proteins from past three years. updated overview complements extensive body work on site-selective proteins, which holds significant relevance across various disciplines, including chemical, biological, medical, material sciences.
Language: Английский
Citations
29
Organic Letters, Journal Year: 2024, Volume and Issue: 26(15), P. 3316 - 3320
Published: April 10, 2024
Operationally simple and generally applicable arene nitration with cheap easily accessible chemicals has been a long-sought transformation in the synthetic organic community. In this work, we realized goal nontoxic inexpensive Fe(NO3)3·9H2O as nitro source recyclable solvent hexafluoroisopropanol promotor via network of hydrogen-bonding interactions. As result relative mildness high reliability protocol, late-stage various highly functionalized natural products commercially available drugs was realized.
Language: Английский
Citations
11
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 468, P. 143468 - 143468
Published: May 19, 2023
Language: Английский
Citations
17
JACS Au, Journal Year: 2024, Volume and Issue: 4(12), P. 4899 - 4909
Published: Nov. 21, 2024
Nitroaromatics, as an important member and source of nitrogen-containing aromatics, is bringing enormous economic benefits in fields pharmaceuticals, dyes, pesticides, functional materials, fertilizers, explosives. Nonetheless, the notoriously polluting nitration industry, which suffers from excessive discharge fumes waste acids, poor group tolerance, tremendous purification difficulty, renders mild, efficient, environmentally friendly a formidable challenge. Herein, we develop visible-light-driven biocompatible arene C–H strategy with good efficiency regioselectivity, marvelous substrate applicability wide application scale-up synthesis, total late-stage functionalization. A nitryl radical delivered through unusual β-homolysis photoexcited ferric-nitrate complex proposed to be key nitrification reagent this system.
Language: Английский
Citations
6
Organic Letters, Journal Year: 2023, Volume and Issue: 25(25), P. 4605 - 4609
Published: June 15, 2023
The development of a new N-nitro type compound, dinitro-5,5-dimethylhydantoin (DNDMH), has been reported as an arene nitration reagent. exploration demonstrated that with DNDMH exhibited good tolerance diverse functional groups. It is notable that, among the two units DNDMH, only unit on N1 was delivered to nitroarene products. compound single N2 cannot promote nitration.
Language: Английский
Citations
12
Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(41)
Published: Aug. 26, 2023
Nitroaromatic compounds represent one of the essential classes molecules that are widely used as feedstock for synthesis intermediates, preparation nitro-derived pharmaceuticals, agrochemicals, and materials on both laboratory industrial scales. We herein disclose efficient, mild, catalytic ipso-nitration organotrimethylsilanes, enabled by an electrophilic N-nitrosaccharin reagent allows chemoselective nitration under mild reaction conditions, while exhibiting remarkable substrate generality functional group compatibility. Additionally, conditions proved to be orthogonal other common functionalities, allowing programming molecular complexity via successive transformations or late-stage nitration. Detailed mechanistic investigation experimental computational approaches strongly supported a classical aromatic substitution (SE Ar) mechanism, which was found proceed through highly ordered transition state.
Language: Английский
Citations
12
Chemical Engineering & Technology, Journal Year: 2025, Volume and Issue: unknown
Published: April 14, 2025
Abstract 3‐Amino‐1‐adamantanol (3AA) is an important intermediate of vildagliptin. In this work, a fully continuous flow synthesis 3‐amino‐1‐adamantanol has been proposed. Selecting amantadine sulfate (AS) as the starting material, effects process parameters were systematically investigated, such molar ratio reactants, amount sulfuric acid and reaction temperature. The kinetics nitration carried out in both batch processes to explain relationship between rate constant. Based on apparent constants thermodynamic parameters, 3AA combining nitration, hydrolysis neutralization realized. Compared with method, time was shortened from 8 h 36 min, side reactions significantly inhibited, yield increased 87.8 % 95.2 by strategy.
Language: Английский
Citations
0
Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141409 - 141409
Published: Jan. 1, 2025
Language: Английский
Citations
0
RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3474 - 3479
Published: Jan. 1, 2025
This continuous-flow mononitration process for aromatic compounds features high yield and selectivity. It is easy to scale up, stable, practical.
Language: Английский
Citations
0
Tetrahedron Letters, Journal Year: 2025, Volume and Issue: 159, P. 155515 - 155515
Published: March 4, 2025
Language: Английский
Citations
0