Sialic Acid-Targeted Ru(II)/Ir(III)/Re(I) Complexes for Ferroptosis Induction in Triple-Negative Breast Cancer DOI
Nilmadhab Roy,

Tiasha Dasgupta,

Sreejani Ghosh

et al.

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Ferroptosis has been recognized as an iron-based nonapoptotic-regulated cell death process. In the quest of resisting unyielding vehemence triple-negative breast cancer (TNBC), herein we have showcased ferroptosis-inducing heteroleptic [LIrcRu], [LIrcIrh], and [LIrcRe] complexes, enabling them to selectively target "sialic acid", overexpressed cell-surface marker. The open-circuit potential (OCP) measurements in live cells revealed specific interaction between TNBC whereas control experiments with normal did not exhibit such interactions. GSH depletion, GPx4 inhibition, NADH/NADPH oxidation, lipid peroxidation, COX-2 activation, Nrf2 inactivation were meticulously investigated upon treatment these complexes establish a strong basis for ferroptosis. Among all complex [LIrcIrh] (IC50 = 25 ± 2.17 μM) well-documented potent ferroptosis inducer, which unveils sturdy sialic acid possessing highest binding constant (Kb 0.71 × 105 M–1, ΔG −279345.8026 kcal/mol) along serum albumin affinity (KHSA 0.67 106 M–1) significant DNA intercalation 0.56 Kapp 1.06 C50 is 76.56 μM), displaying decreased current intensity differential pulse voltammetry (DPV). Moreover, exhibited mitochondrial dysfunction membrane damage (diminished MMP, ΔΨm) through production copious reactive oxygen species (ROS) MDA-MB-231 considerable accumulation mitochondria (Pearson's coefficient 0.842). analysis field emission scanning electron microscopy (FE-SEM) image marked vivid induced by exhibiting ablaze evidence destruction

Language: Английский

Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics DOI Creative Commons
Lawrence Cho‐Cheung Lee, Kenneth Kam‐Wing Lo

Small Methods, Journal Year: 2024, Volume and Issue: 8(11)

Published: Sept. 25, 2024

Abstract Despite the advent of various medical interventions for cancer treatment, disease continues to pose a formidable global health challenge, necessitating development new therapeutic approaches more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light activate photosensitizer produce cytotoxic reactive oxygen species (ROS) eradicating cells, has emerged as promising approach due its high spatiotemporal precision and minimal invasiveness. However, widespread clinical use PDT faces several challenges, including inefficient production ROS in hypoxic tumor microenvironment, limited penetration depth biological tissues, inadequate accumulation photosensitizers at site. Over past decade, there been increasing interest utilization photofunctional transition metal complexes applications their intriguing photophysical photochemical properties. This review provides an overview current design strategies used innovative phototherapeutics, aiming address limitations associated with achieve The challenges future perspectives on translation are also discussed.

Language: Английский

Citations

6
A Phenyl-Modified Aggregation-Induced Phosphorescent Emission-Active Cationic Ru(II) Complex for Detecting Picric Acid in Aqueous Media DOI Creative Commons
Ruimin Chen, Qinglong Zhang,

Liyan Zhang

et al.

Chemosensors, Journal Year: 2025, Volume and Issue: 13(1), P. 14 - 14

Published: Jan. 11, 2025

A cationic Ru(II) complex Ru1 with 5-phenyl-2,2′-bipyridine as ligand was synthesized and fully characterized. exhibits significant aggregation-induced phosphorescent emission (AIPE) activity in THF/H2O. The AIPE property of has been successfully used to detect picric acid (PA) aqueous media. a sensitive luminescence quenching response PA, high constant (KSV = 2.5 × 104 M−1) low limit detection (LOD 91 nM). In addition, demonstrates sensitivity selectivity for detecting PA different common water samples. UV-vis absorption spectra lifetime show an obvious change after the addition into samples, indicating that process is combination dynamic static quenching. density functional theory calculations indicate mechanism photo-induced electron transfer.

Language: Английский

Citations

0
Iron-Dependent Cell Death: Exploring Ferroptosis as a Unique Target in Triple-Negative Breast Cancer Management DOI Creative Commons

L. Tan,

Jiaxing Liu, C Ma

et al.

Cancer Management and Research, Journal Year: 2025, Volume and Issue: Volume 17, P. 625 - 637

Published: March 1, 2025

Triple-negative breast cancer (TNBC) is characterized by aggressive behavior, high metastatic potential, and frequent relapses, presenting significant treatment challenges. Ferroptosis, a unique form of programmed cell death marked iron-dependent lipid peroxidation, has emerged as crucial factor in biology. Recent studies indicate that TNBC cells possess distinct metabolic profile linked to iron glutathione, which may render them more susceptible ferroptosis than other subtypes. Moreover, plays role the interactions between immune tumor cells, suggesting its potential modulate microenvironment influence response against TNBC.Evidence reveals not only affects viability but also alters promoting release damage-associated molecular patterns (DAMPs), can recruit site. Specific ferroptosis-related genes biomarkers, such ACSL4 GPX4, demonstrate altered expression tissues, offering promising avenues for diagnostic prognostic applications. Furthermore, preclinical models, induction been shown enhance efficacy existing therapies, indicating synergistic effect could be harnessed therapeutic benefit. The compelling link underscores novel target. Future research should focus on developing strategies exploit conjunction with traditional including identification natural compounds efficacious inducers personalized regimens. This review elucidates multifaceted implications TNBC, providing valuable insights improving both diagnosis this formidable subtype.

Language: Английский

Citations

0
Modular Engineering of Enzyme‐Activatable DNA Nanodevices for Endoplasmic Reticulum‐Targeted Photodynamic Antitumor Therapy DOI

Dejie Lu,

Yanfei Jia, Yaoxuan Chen

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Abstract Endoplasmic reticulum (ER)‐targeted photodynamic therapy (PDT) has garnered wide attention for its potential to improve tumor treatment outcomes. However, achieving spatially selective control over the activation of photosensitizers (PSs) within ER remains a major challenge. In this study, programmable DNA nanodevice, termed EDEP, designed targeted delivery and localized PSs, thereby ER‐specific activatable therapy, is presented. This modular engineered nanodevice comprises an enzyme‐activatable, DNA‐based PS (ED), nanocarrier ER‐targeting ligand, allowing it accumulate specifically lumen. The ED features unique enzyme‐responsive turn‐on mechanism that selectively activates upon interaction with enzyme, facilitating controlled reactive oxygen species (ROS) generation at subcellular site. It demonstrated EDEP enables ROS production in ER, leading significant cytotoxicity cells. Furthermore, induces mitochondrial permeability transition pore opening, resulting dysfunction amplified cell death. work presents enzyme‐controlled, ER‐targeted PDT strategy holds promise precise cancer therapy.

Language: Английский

Citations

0
Mitochondria-localizing triphenylphosphine-8-hydroxyquinoline Ru complexes induce ferroptosis and their antitumor evaluation DOI

Ting Meng,

Zhong Xu, Hanjie Wang

et al.

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 257, P. 112585 - 112585

Published: May 6, 2024

Language: Английский

Citations

1
Recent Trends on the Design and Delivery Strategies of Ruthenium Complexes for Breast Cancer Therapy DOI
Utpal Das, Uttara Basu, Priyankar Paira

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(36), P. 15113 - 15157

Published: Jan. 1, 2024

As the most frequent and deadly type of cancer in women, breast has a high propensity to spread brain, bones, lymph nodes, lungs. The discovery cisplatin marked beginning development anticancer metal-based medications, although drug's severe side effects have limited its usage clinical settings. remarkable antimetastatic activity different ruthenium complexes such as NAMI-A, KP1019, KP1339,

Language: Английский

Citations

1
Sialic Acid-Targeted Ru(II)/Ir(III)/Re(I) Complexes for Ferroptosis Induction in Triple-Negative Breast Cancer DOI
Nilmadhab Roy,

Tiasha Dasgupta,

Sreejani Ghosh

et al.

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Ferroptosis has been recognized as an iron-based nonapoptotic-regulated cell death process. In the quest of resisting unyielding vehemence triple-negative breast cancer (TNBC), herein we have showcased ferroptosis-inducing heteroleptic [LIrcRu], [LIrcIrh], and [LIrcRe] complexes, enabling them to selectively target "sialic acid", overexpressed cell-surface marker. The open-circuit potential (OCP) measurements in live cells revealed specific interaction between TNBC whereas control experiments with normal did not exhibit such interactions. GSH depletion, GPx4 inhibition, NADH/NADPH oxidation, lipid peroxidation, COX-2 activation, Nrf2 inactivation were meticulously investigated upon treatment these complexes establish a strong basis for ferroptosis. Among all complex [LIrcIrh] (IC50 = 25 ± 2.17 μM) well-documented potent ferroptosis inducer, which unveils sturdy sialic acid possessing highest binding constant (Kb 0.71 × 105 M–1, ΔG −279345.8026 kcal/mol) along serum albumin affinity (KHSA 0.67 106 M–1) significant DNA intercalation 0.56 Kapp 1.06 C50 is 76.56 μM), displaying decreased current intensity differential pulse voltammetry (DPV). Moreover, exhibited mitochondrial dysfunction membrane damage (diminished MMP, ΔΨm) through production copious reactive oxygen species (ROS) MDA-MB-231 considerable accumulation mitochondria (Pearson's coefficient 0.842). analysis field emission scanning electron microscopy (FE-SEM) image marked vivid induced by exhibiting ablaze evidence destruction

Language: Английский

Citations

1