Nanotechnology for Multimodal Synergistic Cancer Therapy

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(22), P. 13566 - 13638

Published: Oct. 19, 2017

The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic potential treatment. Therefore, current trend in clinical research has gradually shifted from a focus on monotherapy to combination therapy for enhanced treatment efficacy. More importantly, cooperative enhancement interactions between several types contribute naissance multimodal synergistic therapy, which results remarkable superadditive (namely "1 + 1 > 2") effects, stronger than any single or their theoretical combination. In this review, state-of-the-art studies concerning recent advances nanotechnology-mediated will be systematically discussed, with an emphasis construction multifunctional nanomaterials realizing bimodal trimodal as well intensive exploration underlying mechanisms explaining significant improvements outcome. Furthermore, featured applications overcoming tumor multidrug resistance, hypoxia, metastasis also discussed detail, may provide new ways efficient regression even elimination drug resistant, hypoxic solid, distant metastatic tumors. Finally, some design tips outlook future development provided, highlighting key scientific issues technical challenges requiring remediation accelerate translation.

Language: Английский

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Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics

Theranostics, Journal Year: 2016, Volume and Issue: 6(6), P. 762 - 772

Published: Jan. 1, 2016

Cancer metastasis accounts for the high mortality of many types cancer.Owing to unique advantages specificity and minimal invasiveness, photothermal therapy (PTT) has been evidenced with great potential in treating cancer metastasis.In this review, we outline current approaches PTT respect its application metastatic cancer.PTT can be used alone, guided multimodal imaging, or combined available therapies effective treatment metastasis.Numerous nanotherapeutics (PTN) have developed encouraging therapeutic efficacy on preclinical animal experiments.We summarize design performance various PTN alone their combinational therapy.We also point out lacking area most promising challenging field.In conclusion, provide an essential modality against metastasis.

Language: Английский

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Light in diagnosis, therapy and surgery

Nature Biomedical Engineering, Journal Year: 2017, Volume and Issue: 1(1)

Published: Jan. 10, 2017

Language: Английский

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Recent advances in functional nanomaterials for light–triggered cancer therapy

Nano Today, Journal Year: 2018, Volume and Issue: 19, P. 146 - 187

Published: March 18, 2018

Language: Английский

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Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(49)

Published: July 29, 2018

Optical imaging has played a pivotal role in biology and medicine, but it faces challenges of relatively low tissue penetration poor signal-to-background ratio due to light scattering autofluorescence. To overcome these issues, second near-infrared fluorescence, self-luminescence, photoacoustic have recently emerged, which utilize an optical region with reduced light-tissue interactions, eliminate real-time excitation, detect acoustic signals negligible attenuation, respectively. Because there are only few endogenous molecules absorbing or emitting above the visible region, development contrast agents is essential for those deep-tissue modalities. Organic semiconducting π-conjugated frameworks can be synthesized meet different requirements their easy chemical modification legible structure-property relation. Herein, applications organic including small-molecule nanoparticle derivatives summarized. In particular, molecular engineering nanoformulation approaches further improve detection sensitivity modalities highlighted. Finally, current potential opportunities this emerging subfield biomedical discussed.

Language: Английский

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GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(42)

Published: Sept. 11, 2020

Abstract Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an emerging technology for therapeutic treatment of various malignant tumors. However, the relatively deficient catalytic activity nanozymes in tumor microenvironment (TME) restrains their biomedical applications. Here, a versatile and bacteria‐like PEG/Ce‐Bi@DMSN nanozyme developed by coating uniform Bi 2 S 3 nanorods (NRs) with dendritic mesoporous silica (Bi @DMSN) then decorating ultrasmall ceria into large mesopores @DMSN. The exhibit dual enzyme‐mimic activities (peroxidase‐mimic catalase‐mimic) under acidic conditions that can regulate TME, is, simultaneously elevate oxidative stress relieve hypoxia. In addition, effectively consume overexpressed glutathione (GSH) through redox reaction. Photothermal therapy (PTT) introduced to synergistically improve enzyme‐mimicking depletion GSH tumors photonic hyperthermia. This achieved taking advantage desirable light absorbance second near‐infrared (NIR‐II) window nanozymes. Subsequently reactive oxygen species (ROS)‐mediated efficiency significantly improved. Therefore, this study provides proof concept hyperthermia‐augmented multi‐enzymatic ablation.

Language: Английский

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Metal Ion/Tannic Acid Assembly as a Versatile Photothermal Platform in Engineering Multimodal Nanotheranostics for Advanced Applications

ACS Nano, Journal Year: 2018, Volume and Issue: 12(4), P. 3917 - 3927

Published: March 26, 2018

This study reports a family of photothermal materials, metal ion/tannic acid assemblies (MITAs). MITAs from FeIII, VIII, and RuIII afford excellent efficiency (η ≈ 40%). Sharply differing the currently existing agents, are highlighted by merits including green synthesis, facile incorporation diagnostic ions, particularly topology-independent adhesion. Owing to adhesion nature MITAs, various kinds MITA-based nanoengineerings readily available via self-adhesion onto diverse templates, enabling well suited as platform for versatile combination with other therapy approaches imaging techniques. As proof concept, polymeric/inorganic nanoparticle/nanovesicle-supported FeIII-tannic (FeIIITA) is fabricated. The effect shown be unaffected template origin type FeIIITA thickness on templates. We validate potency nanovesicle-supported (PNV@FeIIITA) tumor-specific photoactivated utilizations, NIR complete tumor elimination, (PTI), photoacoustic (PAI) in addition T1-MRI imaging. PNV@FeIIITA can simultaneously equipped functionalities, T2-MRI additionally doping MnII fluorescence encapsulating hydrophilic fluoroprobe. MITA demonstrates unparalleled superiority engineering multimodal theranostics advanced applications.

Language: Английский

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Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy

ACS Nano, Journal Year: 2015, Volume and Issue: 9(12), P. 12451 - 12463

Published: Oct. 23, 2015

Designing a multifunctional nanomedicine for integration of precise diagnosis and effective treatment tumors is desirable but remains great challenge. Here, we report based on WS2 quantum dots (QDs), which was prepared by facile "green" method through physical grinding ultrasonication. The as-obtained QDs with small size (3 nm) possess not only significant X-ray computed tomography (CT)/photoaccoustic (PA) imaging signal enhancement also remarkable photothermal therapy (PTT)/radiotherapy (RT) synergistic effect tumor treatment. With CT/PA the between PTT RT, could be accurately positioned thoroughly eradicated in vivo after intravenous injection QDs. Moreover, hematoxylin eosin staining, blood hematology, biochemistry analysis revealed no noticeable toxicity vitro vivo, confirmed that good biocompatibility. This nanoparticle play an important role facilitating simultaneously multimodal RT to achieve better therapeutic efficacy.

Language: Английский

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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(4), P. 1253 - 1321

Published: Jan. 1, 2020

Bismuth-containing nanomaterials offer a new opportunity to move beyond current achievements in the fields of drug delivery, diagnosis, cancer therapy, biosensing, and tissue engineering. This review describes emerging applications perspective these nanoparticles.

Language: Английский

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Size-Dependent Ag₂S Nanodots for Second Near-Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy

ACS Nano, Journal Year: 2017, Volume and Issue: 11(2), P. 1848 - 1857

Published: Jan. 24, 2017

Ag2S nanoparticles are increasingly important in biomedicine, such as cancer imaging. However, there has been only limited success the exploration of theranostic for photoinduced imaging and simultaneous therapy. Here we report size-dependent nanodots (NDs) with well-defined nanostructure a agent multimodal photothermal The NDs precisely synthesized through carefully controlled growth hollow human serum albumin nanocages. These produce effective fluorescence second near-infrared (NIR-II) region, distinct photoacoustic intensity, good conversion manner under light irradiation, thereby generating sufficient vivo signals well potent hyperthermia at tumors. Moreover, possess ideal resistance to photobleaching, cellular uptake, preferable tumor accumulation, elimination, thus facilitating NIR-II fluorescence/photoacoustics both ultrasensitivity microscopic spatial resolution ablation. findings provide insight into clinical potential theranostics.

Language: Английский

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