Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(7), P. 2053 - 2108

Published: Sept. 27, 2018

The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis cancer, respectively. By taking advantage nanocarriers, both imaging therapeutic functions together with enhanced tumour accumulation have thoroughly studied to improve pre-clinical efficiency PAI PTT. In this review, we first summarize development inorganic organic nano photothermal transduction agents (PTAs) strategies improving PTT outcomes, including applying appropriate laser dosage, guiding via techniques, developing PTAs absorption in second NIR window, increasing (PCE), also tumours. Second, introduce advantages combining other therapies cancer treatment. Third, emerging applications cancer-related research are exemplified. Finally, perspectives challenges combating especially regarding their clinical translation, discussed. We believe that having noteworthy features would become promising next-generation non-invasive theranostic techniques our ability combat cancers.

Language: Английский

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Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Advanced Materials, Journal Year: 2018, Volume and Issue: 31(6)

Published: Dec. 17, 2018

Abstract Photoacoustic (PA) imaging as a fast‐developing technique has great potential in biomedical and clinical applications. It is noninvasive modality that depends on the light‐absorption coefficient of imaged tissue injected PA‐imaging contrast agents. Furthermore, PA provides superb contrast, super spatial resolution, high penetrability sensitivity to functional characteristics by detecting acoustic wave construct images. In recent years, series agents are developed improve performance Here, progress their applications outlined. classified according components function, gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based other inorganic agents, small organic molecules, semiconducting polymer nanoparticles, nonlinear discussed. The biosensors (in sensing metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, nitrogen species) bioimaging (lymph nodes, vasculature, tumors, brain tissue) discussed detail. Finally, an outlook future research investigation significance presented.

Language: Английский

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Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8762 - 8789

Published: Jan. 1, 2021

Photothermal therapy (PTT)-derived multimodal synergistic treatments exhibit a super-additive effect in fighting bacterial infections.

Language: Английский

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Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

ACS Nano, Journal Year: 2018, Volume and Issue: 12(12), P. 12181 - 12192

Published: Nov. 20, 2018

Non-apoptotic ferroptosis is of clinical importance because it offers a solution to the inevitable biocarriers traditional apoptotic therapeutic means. Inspired by industrial electro-Fenton technology featured with electrochemical iron cycling, we construct ferrous-supply-regeneration nanoengineering intervene tumorous metabolism for enhanced ferroptosis. Fe3+ ion and naturally derived tannic acid (TA) spontaneously form network-like corona onto sorafenib (SRF) nanocores. The formed SRF@FeIIITA nanoparticles can respond lysosomal environment dissociation, permitting SRF release inhibit GPX4 enzyme initiation. TA arranged chemically reduce liberated ferroptosis-generated Fe2+, offering redox cycling to, thus, effectively produce lipid peroxide required in Sustained Fe2+ supply leads long-term cytotoxicity, which identified be specific H2O2-overloaded cancer cells but minimal normal cells. SRF@FeIIITA-mediated cell death proves follow pathway strongly inhibits tumor proliferation. Moreover, provides powerful platform capable versatile integration between apoptosis non-apoptosis Typically, photosensitizer-adsorbed demonstrates rapid imaging owing acid-responsive fluorescence recovery. Together ferroptosis, imaging-guided photodynamic therapy induces complete elimination. This study ideas about how advance anticancer through rational material design.

Language: Английский

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Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(22)

Published: April 19, 2021

Abstract Polyphenols, the phenolic hydroxyl group‐containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol‐containing nanoparticles attracted extensive research attention due to their antioxidation property, anticancer activity, universal adherent affinity, thus great promise preparation, stabilization, modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, other biomedical applications. Additionally, metal−polyphenol networks, formed by coordination interactions between polyphenols metal ions, been used prepare an important class surface modification, drug disease treatments. By focusing different materials (e.g., inorganic materials, polymers, proteins, nucleic acids), a comprehensive review synthesis properties is provided. Moreover, remarkable versatility applications, including biodetection, multimodal protein gene bone repair, antibiosis, cancer theranostics also demonstrated. Finally, challenges faced future regarding discussed.

Language: Английский

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Polyphenol-Mediated Assembly for Particle Engineering

Accounts of Chemical Research, Journal Year: 2020, Volume and Issue: 53(7), P. 1269 - 1278

Published: June 22, 2020

ConspectusPolyphenols are naturally occurring compounds that ubiquitous in plants and display a spectrum of physical, chemical, biological properties. For example, they antioxidants, have therapeutic properties, absorb UV radiation, complex with metal ions. Additionally, polyphenols high adherence, which has been exploited for assembling nanostructured materials. We previously reviewed the assembly different phenolic materials their applications (Angew. Chem. Int. Ed. 2019, 58, 1904–1927); however, there is need summary fundamental interactions govern assembly, stability, function polyphenol-based A detailed understanding between various other building blocks will facilitate rational design advanced polyphenol particles specific applications. This Account discusses how bonding (i.e., hydrogen, π, hydrophobic, coordination, covalent, electrostatic) can be leveraged to assemble stabilize diverse In polyphenol-mediated strategies, typically exert more than one type stabilizing attractive force. However, interaction often dominates process dictates physicochemical behavior particles, turn influences potential thus divided into sections each focus on key relevant examples highlight structure–function relationships. coordination generally becomes weaker at lower pH, makes it possible engineer metal–phenolic pH-responsive disassembly profile suitable drug delivery. Engineered such as hollow capsules, mesoporous core–shell self-assembled nanoparticles some systems covered interact therefore make up major this Account. Some these exemplified include delivery, catalysis, environmental remediation, forensics. Finally, perspective provided current challenges trends particle viable near-term strategies further elucidating interplay competing formation discussed. also expected serve reference guide research emerging

Language: Английский

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Applications of tannic acid in membrane technologies: A review

Advances in Colloid and Interface Science, Journal Year: 2020, Volume and Issue: 284, P. 102267 - 102267

Published: Sept. 9, 2020

Language: Английский

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Multifunctional and Recyclable Photothermally Responsive Cryogels as Efficient Platforms for Wound Healing

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 29(35)

Published: July 15, 2019

Abstract A growth in the use of antibiotics and related evolution patients' drug resistance calls for an urgent response development novel curing approaches without using synthetic antibiotics. Here, fabrication a low‐cost cryogel wound dressing applications is demonstrated. The composed only naturally derived components, including chitosan/silk fibroin as scaffold tannic acid/ferric ion (TA/Fe 3+ ) stimuli‐responsive agent photothermal therapy. Based on multiple weak hydrogen bonds metal ligand coordination, exhibits good flexibility recoverability. Its highly porous structure renders to be strongly hygroscopic absorb blood hemostasis. excellent antibacterial activity both Gram‐negative positive bacteria, benefiting from high transition TA/Fe complex. Furthermore, can efficiently promote cell proliferation vitro. Significantly, animal experiments also reveal that effectively eradicate microbes at accelerate healing process. In summary, this biorenewable demonstrates hemostatic performance, antimicrobial activity, accelerates skin regeneration, which has great application potential promising material clinical use.

Language: Английский

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Polyphenol scaffolds in tissue engineering

Materials Horizons, Journal Year: 2020, Volume and Issue: 8(1), P. 145 - 167

Published: Sept. 17, 2020

Polyphenols are a class of ubiquitous compounds distributed in nature, with fascinating inherent biocompatible, bioadhesive, antioxidant, and antibacterial properties. The unique polyphenolic structures based on catechol or pyrogallol moieties allow for strong non-covalent interactions (e.g., multiple hydrogen bonding, electrostatic, cation-π interactions) as well covalent Michael addition/Schiff-base reaction, radical coupling dynamic coordination boronate metal ions). This review article provides an overview the polyphenol-based scaffolds including hydrogels, films, nanofibers that have emerged from chemical functional signatures during past years. A full description structure-function relationships terms their utilization wound healing, bone regeneration, electroactive tissue engineering is also carefully discussed, which may pave path towards rational design facile preparation next-generation polyphenol applications.

Language: Английский

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Recent advances in selective photothermal therapy of tumor

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: Oct. 24, 2021

Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways improve the efficiency of tumor ablation treat cancer, PTT may cause severe damage normal tissue due systemic distribution photothermal agents (PTAs) body and inaccurate laser exposure during To further survival rate patients reduce possible side effects on other parts body, it is still necessary explore PTAs with high selectivity precise In this review, we summarized strategies treatment PTT, such as increasing accumulation at sites endowing self-regulating conversion function. The views challenges selective were discussed, especially prospects their clinical applications.

Language: Английский

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