Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline

Journal of Alzheimer s Disease, Journal Year: 2021, Volume and Issue: 83(3), P. 1379 - 1389

Published: Aug. 20, 2021

Depressive symptoms may increase risk for dementia, but findings are controversial because late-life depression be a prodromal dementia symptom. Life course data on and clarify this association; however, is limited.

Language: Английский

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A meta‐analysis of the relation between hippocampal volume and memory ability in typically developing children and adolescents

Hippocampus, Journal Year: 2022, Volume and Issue: 32(5), P. 386 - 400

Published: March 17, 2022

Memory is supported by a network of brain regions, with the hippocampus serving critical role in this cognitive process. Previous meta-analyses on association between hippocampal structure and memory have largely focused adults. Multiple studies since suggested that volume related to performance children adolescents; however, strength direction relation varies across reports, thus, remains unclear. To further understand brain-behavior relation, we conducted meta-analysis investigate (assessed as total volume) during typical development. Across 25 61 outcomes 1357 participants, results showed small, but significant, positive performance. Estimates variability were not explained differences task type (delayed vs. immediate; relational nonrelational), participant age range, or method normalization volumes. Overall, findings suggest larger relates better adolescents similar types ranges assessed. facilitate enhanced generalization future, discuss considerations for field moving forward.

Language: Английский

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Therapeutic applications of transcutaneous auricular vagus nerve stimulation with potential for application in neurodevelopmental or other pediatric disorders

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 12, 2022

Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) as a newly developed technique involves stimulating the cutaneous receptive field formed by branch of in outer ear, with resulting activation vagal connections to central and peripheral nervous systems. Increasing evidence indicates that maladaptive neural plasticity may underlie pathology several pediatric neurodevelopmental psychiatric disorders, such autism spectrum disorder, attention deficit hyperactivity disruptive behavioral disorder stress-related disorder. Vagal therefore provide useful intervention for treating plasticity. In current review we summarize literature primarily on therapeutic use adults discuss prospects applying taVNS specific other disorders. Furthermore, also briefly factors would help optimize protocols future clinical applications. We conclude from these initial findings be promising alternative treatment disorders which do not respond interventions.

Language: Английский

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Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity

Theranostics, Journal Year: 2023, Volume and Issue: 13(3), P. 913 - 930

Published: Jan. 1, 2023

Rationale: Adverse experiences in early life including abuse, trauma and neglect, have been linked to poor physical mental health outcomes. Emerging evidence implies that those who experienced adversity (ELA) are more likely develop cognitive dysfunction depressive-like symptoms adulthood. The molecular mechanisms responsible for the negative consequences of ELA, however, remain unclear. In absence effective management options, anticipatory guidance is mainstay ELA prevention. Furthermore, there no available treatment prevents or alleviates neurologic sequelae especially traumatic stress. Hence, present study aims investigate these associations evaluate whether photobiomodulation (PBM), a non-invasive therapeutic procedure, can prevent behavioral manifestations later life. Methods: was induced by repeated inescapable electric foot shock rats from postnatal day 21 26. On immediately following last shock, 2-min daily PBM applied transcranially 7 consecutive days. Cognitive depression-like behaviors were measured battery tests Subsequently, oligodendrocyte progenitor cells (OPCs) differentiation, proliferation apoptosis lineage (OLs), mature oligodendrocyte, myelinating level oxidative damage, reactive oxygen species (ROS) total antioxidant capacity analyzed using immunofluorescence staining, capillary-based immunoassay (ProteinSimple®) assay kit. Results: exposed exhibited obvious dysfunction, reduction OPCs diminished generation survival OLs, decreased matured oligodendrocyte. deficit oligodendrocytes observed, conjunction with an imbalance redox homeostasis accumulated damage. These alternations concomitant behaviors. Importantly, we found largely prevented pathologies reversed resulting ELA. Conclusions: Collectively, findings provide new insights into mechanism which affects neurological Moreover, our support may be promising strategy ELA-induced develops

Language: Английский

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Neonatal maternal separation causes depressive-like behavior and potentiates memory impairment induced by amyloid-β oligomers in adult mice

Behavioral and Brain Functions, Journal Year: 2025, Volume and Issue: 21(1)

Published: March 20, 2025

Alzheimer's disease (AD) is characterized by memory decline and mood alterations. A growing body of evidence implicates stress other social determinants health as potential contributors to the progressive cerebral alterations that culminate in AD. In current study, we investigated impact neonatal maternal separation (MS) on susceptibility male female mice AD-associated impairments depressive-like behavior adulthood, brain levels pro-inflammatory cytokines neurotransmitters. Male Swiss were exposed MS for 180 min daily from post-natal day 1 10. Seventy days post-MS, received an intracerebroventricular infusion amyloid-β oligomers (AβOs), evaluated. Levels TNF-α, IL-1β, serotonin, dopamine, related metabolites determined cortex hippocampus. Previous exposure alone did not cause adult mice. Interestingly, however, increased impairment induced AβOs, potentiated inhibitory AβOs females. Females more susceptible caused a low dose regardless MS. No changes IL-1β found. decrease TNF-α was selectively found females pmol AβOs. led increase serotonin (5-HT) hippocampus mice, without influencing metabolite, 5-HIAA. Changes turnover predominantly observed dopamine or its Neonatal enhances cognitive deficits sex-specific manner. This suggests early life may play role development

Language: Английский

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