Early life adversity as a risk factor for cognitive impairment and Alzheimer’s disease

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: May 12, 2023

Abstract Neurological conditions, including cognitive impairment and Alzheimer’s disease (AD), impose a huge burden on society, affecting millions of people globally. In addition to genetic factors, recent studies indicate that environmental experiential factors may contribute the pathogenesis these diseases. Early life adversity (ELA) has profound impact brain function health later in life. rodent models, exposure ELA results specific deficits aggravated AD pathology. Extensive concerns have been raised regarding higher risk developing impairments with history ELA. this review, we scrutinize findings from human animal focusing connection AD. These discoveries suggest ELA, especially at early postnatal stages, increases susceptibility terms mechanisms, could lead dysregulation hypothalamus-pituitary-adrenal axis, altered gut microbiome, persistent inflammation, oligodendrocyte dysfunction, hypomyelination, aberrant adult hippocampal neurogenesis. Crosstalks among events synergistically Additionally, discuss several interventions alleviate adverse consequences Further investigation into crucial area will help improve management reduce related neurological conditions.

Language: Английский

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Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: Nov. 14, 2023

Abstract Oligodendrocyte progenitor cells (OPCs) play pivotal roles in myelin formation and phagocytosis, communicating with neighboring contributing to the integrity of blood–brain barrier (BBB). However, under pathological circumstances Alzheimer’s disease (AD), brain’s microenvironment undergoes detrimental changes that significantly impact OPCs their functions. Starting OPC functions, we delve into transformation myelin-producing oligodendrocytes, intricate signaling interactions other central nervous system (CNS), fascinating process which influences function affects CNS homeostasis. Moreover, discuss essential role BBB highlight critical contribution forming CNS-protective barriers. In context AD, deterioration local brain is discussed, mainly focusing on neuroinflammation, oxidative stress, accumulation toxic proteins. The disturb delicate balance brain, impacting regenerative capacity compromising integrity. Under conditions, experience significant alterations migration proliferation, leading impaired differentiation a reduced ability produce mature oligodendrocytes. degeneration become increasingly active progressive neurodegeneration. Finally, summarize current therapeutic approaches targeting AD. Strategies revitalize senescence, modulate pathways enhance differentiation, explore potential avenues are promising alleviating AD function. conclusion, this review highlights indispensable involvement pathogenesis interplay between underscores complexity neurodegenerative diseases. Insights from studying conditions provide foundation for innovative strategies fostering Future research will advance our understanding management diseases, ultimately offering hope effective treatments improved quality life those affected by related disorders.

Language: Английский

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Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Photobiomodulation (PBM) therapy stands as an innovative neurostimulation modality that has demonstrated both efficacy and safety in improving brain function. This exerts multifaceted influences on neurons, blood vessels, their intricate interplay known neurovascular coupling (NVC). Growing evidence indicates NVC may present a promising target for PBM intervention. However, the detailed mechanisms underlying its therapeutic benefits remain to be fully understood. review aims elucidate potential metabolic pathways signaling cascades involved modulatory effects of PBM, while also exploring extensive repertoire applications neurologic psychiatric conditions. The prospects within realm investigation are intensively considered, providing deeper insights into powerful capabilities revolutionize treatments.

Language: Английский

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Phototherapy for age-related brain diseases: Challenges, successes and future

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102183 - 102183

Published: Jan. 11, 2024

Brain diseases present a significant obstacle to both global health and economic progress, owing their elusive pathogenesis the limited effectiveness of pharmaceutical interventions. Phototherapy has emerged as promising non-invasive therapeutic modality for addressing age-related brain disorders, including stroke, Alzheimer's disease (AD), Parkinson's (PD), among others. This review examines recent progressions in phototherapeutic Firstly, article elucidates various wavelengths visible light that possess capability penetrate skin skull, well pathways stimulation, encompassing eyes, skin, veins, skull. Secondly, it deliberates on molecular mechanisms photosensitive proteins, within context disorders other modulation. Lastly, practical application phototherapy diverse clinical neurological is indicated. Additionally, this presents novel approaches combine pharmacological Moreover, outlines limitations phototherapeutics proposes innovative strategies improve treatment cerebral disorders.

Language: Английский

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Photobiomodulation of Neurogenesis through the Enhancement of Stem Cell and Neural Progenitor Differentiation in the Central and Peripheral Nervous Systems

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15427 - 15427

Published: Oct. 21, 2023

Photobiomodulation (PBM) is the regulation of biological processes using light energy from sources such as lasers or light-emitting diodes. Components nervous system, brain and peripheral nerves, are important candidate PBM targets due to lack therapeutic modalities for complete cure neurological diseases. can be applied either regenerate damaged organs prevent reduce damage caused by disease. Although recent findings have suggested that neural cells regenerated, which contradicts our previous understanding, structures still thought weaker regenerative capacity than other systems. Therefore, enhancing system would aid future development therapeutics degeneration. has been shown enhance cell differentiation stem progenitor near-target target cells. In this review, we reviewed research on effects neurogenesis in central (e.g., animal brains) sensory structures) sought its potential a tool intractable degenerative disorders.

Language: Английский

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Photostimulation of lymphatic clearance of β-amyloid from mouse brain: a new strategy for the therapy of Alzheimer’s disease

Frontiers of Optoelectronics, Journal Year: 2023, Volume and Issue: 16(1)

Published: Dec. 14, 2023

Alzheimer's disease (AD) is an age-related neurodegenerative disorder that poses a significant burden on socio-economic and healthcare systems worldwide. However, the currently available therapy of AD limited, new strategies are needed to enhance clearance β-amyloid (Aβ) protein improve cognitive function. Photobiomodulation (PBM) non-invasive effective therapeutic method has shown promise in treating various brain diseases. Here, we demonstrate 1267-nm PBM significantly alleviates decline 5xFAD mouse model safe as it does not induce increase cortical temperature. Moreover, with combination 3D tissue optical clearing imaging automatic region segmentation, show PBM-mediated reductions Aβ plaques different subregions prefrontal cortex hippocampus different. The PBM-induced lymphatic from associated improvement memory functions mice. Our results suggest modulation meningeal vessels (MLVs) should play important role promoting clearance. Collectively, this pilot study demonstrates can safely accelerate mice, neurocognitive status animals suggesting be bedside for AD.

Language: Английский

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Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury

Translational research, Journal Year: 2024, Volume and Issue: 268, P. 40 - 50

Published: Jan. 19, 2024

Language: Английский

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Intermittent theta-burst stimulation alleviates hypoxia-ischemia-caused myelin damage and neurologic disability

Experimental Neurology, Journal Year: 2024, Volume and Issue: 378, P. 114821 - 114821

Published: May 21, 2024

Language: Английский

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Exercise-induced upregulation of TRIM9 attenuates neuroinflammation in Alzheimer’s disease-like rat

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113676 - 113676

Published: Nov. 23, 2024

Language: Английский

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Photobiomodulation Literature Watch February 2023

Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2023, Volume and Issue: 41(7), P. 371 - 375

Published: July 1, 2023

Language: Английский

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