Clinical Therapeutics, Journal Year: 2023, Volume and Issue: 45(6), P. 562 - 577
Published: June 1, 2023
Language: Английский
European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2018, Volume and Issue: 269(1), P. 107 - 120
Published: Dec. 19, 2018
Language: Английский
Citations
207
Substance Abuse Research and Treatment, Journal Year: 2023, Volume and Issue: 17
Published: Jan. 1, 2023
Background: Recreational cannabis legalization has become more prevalent over the past decade, increasing need to understand its impact on downstream health-related outcomes. Although prior reviews have broadly summarized research liberalization policies (including decriminalization and medical legalization), directed efforts are needed synthesize recent that focuses recreational specifically. Thus, current review summarizes existing studies using longitudinal designs evaluate impacts of use related Method: A comprehensive bibliographic search strategy revealed 61 published from 2016 2022 met criteria for inclusion. The were predominantly United States (66.2%) primarily utilized self-report data (for attitudes) or administrative health-related, driving, crime outcomes). Results: Five main categories outcomes identified through review: other substance use, attitudes toward cannabis, health-care utilization, driving-related outcomes, crime-related extant literature mixed findings, including some evidence negative consequences (such as increased young adult cannabis-related healthcare visits, impaired driving) minimal little change in adolescent rates, changes attitudes). Conclusions: Overall, reveals a number legalization, although findings generally do not suggest large magnitude short-term impacts. highlights systematic investigation, particularly across greater diversity geographic regions.
Language: Английский
Citations
71
Medicina, Journal Year: 2019, Volume and Issue: 55(9), P. 525 - 525
Published: Aug. 23, 2019
Background and Objectives: Post-traumatic stress disorder (PTSD) is a common psychiatric resulting from traumatic event, manifested through hyperarousal, anxiety, depressive symptoms, sleep disturbances. Despite several therapeutic approaches being available, both pharmacological psychological, recently growing interest has developed in using cannabis synthetic cannabinoids stems their consideration as more efficient better tolerated alternatives for the treatment of this condition. The present paper aims to evaluate clinical potentials medical treating PTSD patients. Methods: A systematic electronic search was performed, including all papers published up May 2019, following keywords (((cannabis[Title/Abstract]) OR (synthetic [Title/Abstract])) AND ((PTSD[Title/Abstract]) (Posttraumatic disorder[Title/Abstract]))) topics ‘Cannabis’, ‘Synthetic Cannabinoids’, ‘PTSD’, MESH terms, on PubMed, Cochrane Library, Web Science online databases. For data gathering purposes, PRISMA guidelines were followed. Results organized into two groups, considering different PTSD. Results: Present show that cannabinoids, acting endocannabinoids system, may have potential use improving e.g., reducing modulating memory-related processes, sleep. Conclusions: Even though current literature suggests role PTSD, there currently limited evidence regarding safety efficacy. Therefore, additional research needed order understand effectiveness usage these drug classes monitor safety.
Language: Английский
Citations
128
Alcoholism Clinical and Experimental Research, Journal Year: 2018, Volume and Issue: 42(6), P. 1096 - 1104
Published: April 15, 2018
Background The study aims were to examine daily associations between marijuana and alcohol use the extent which association differs as a function of cannabis disorder ( CUD ) and/or AUD diagnosis. Methods Timeline Followback interview data was collected in veterans N = 127) recruited from Veterans Affairs hospital who reported at least 1 day co‐use past 180 days (22,860 observations). Participants 40% days, 28% drinking with 37% meeting DSM ‐5 criteria for , 15% both. Use on given used predict 3‐level gender‐adjusted variable (heavy: ≥ 5 (men)/4 (women) drinks; moderate: 4/3 or none: 0 drinks). A categorical 4‐level (no diagnosis, both) tested moderator marijuana–alcohol relationship. Results Multilevel modeling analyses demonstrated that participants more likely drink heavily compared moderately OR 2.34) not 1.61) relative nonuse days. On those + 1.91; 2.51, respectively), but less 0.32) moderately, nonsignificant differences any versus moderate interaction models. Conclusions Heavy occurs when is also used. This particularly evident individuals diagnosed both AUDs alone only CUDs. Findings suggest interventions may need specifically address risk factor heavy .
Language: Английский
Citations
91
Alcohol research, Journal Year: 2022, Volume and Issue: 40(2)
Published: Feb. 18, 2022
The purpose of this review is to discuss the literature regarding concurrent use (co-use) alcohol and cannabis competing hypotheses as whether acts a substitute for (i.e., replacing effects alcohol, resulting in decreased use) or complement used enhance increased alcohol. impact on alcohol-related outcomes has received attention wake ongoing legalization both medical recreational purposes. Evidence exists across broad range data collection methods samples carefully reviewed here. In addition, various mechanisms by which may act an are explored depth with goal better understanding equivocal findings. This includes articles that were identified from search studies co-use, specific focus exploring complementary versus substitution aspects co-use. Search terms included Google Scholar, PsycINFO, MEDLINE, Web Science. Eligible those measured co-use human laboratory, survey, ecological momentary assessment studies, directly referenced patterns use. results returned 650 articles, 95 meeting inclusion criteria. Results reveal compelling evidence effects, suggesting nuanced yet significant distinctions different populations examined these studies. Several identified, including context timing order use, cannabinoid formulation, pharmacokinetic interactions, user characteristics (including diagnostic status), all influence effects. will inform future research examining topic clinical community aid development treatment prevention efforts targeting most vulnerable negative consequences Finally, highlights need additional more diverse mixed-methods designs examine pharmacological contextual influences
Language: Английский
Citations
66
Drug and Alcohol Dependence, Journal Year: 2018, Volume and Issue: 191, P. 223 - 233
Published: Aug. 15, 2018
Language: Английский
Citations
78
Journal of Dual Diagnosis, Journal Year: 2019, Volume and Issue: 16(1), P. 120 - 139
Published: Sept. 3, 2019
Objectives: Posttraumatic stress disorder (PTSD) is a potentially debilitating mental health problem. There has been recent surge of interest regarding the use cannabinoids in treatment PTSD. We therefore sought to systematically review and assess quality clinical evidence effectiveness for Method: included all studies published until December 2018 where patient had PTSD diagnosed prescribed or were using cannabinoid purpose reducing symptoms. Our primary outcome measure was reduction symptoms validated instrument. In absence randomized controlled trials, we next best available levels including observational retrospective case reports. assessed risk bias tools appropriate study design. Results: 10 this review, which only one pilot randomized, double-blind, placebo-controlled, crossover trial. Every identified medium high low quality. found that may decrease symptomology, particular sleep disturbances nightmares. Conclusions: Most date are small quality, with significant limitations designs precluding any recommendations about its routine practice. Evidence help reduce global symptoms, disturbances, nightmares indicates future well-controlled, double-blind trials highly warranted.PROSPERO registration number: 121646
Language: Английский
Citations
51
Drug and Alcohol Dependence, Journal Year: 2019, Volume and Issue: 205, P. 107661 - 107661
Published: Oct. 23, 2019
Language: Английский
Citations
43
Medicines, Journal Year: 2018, Volume and Issue: 5(4), P. 107 - 107
Published: Oct. 2, 2018
Following the discovery of endocannabinoid system and its potential as a therapeutic target for various pathological conditions, growing interest led researchers to investigate role cannabis derivatives medical purposes. The compounds Δ9-tetrahydrocannabinol cannabidiol are most abundant phytocannabinoids found in extracts, well studied. present review aims provide an overview current evidence their beneficial effects treating psychiatric disorders, including schizophrenia, anxiety, depression. Nevertheless, further investigations required clarify many pending issues, especially those relative assessment benefits risks when using purposes, thereby also helping national federal jurisdictions remain updated.
Language: Английский
Citations
39
Psychology of Addictive Behaviors, Journal Year: 2021, Volume and Issue: 35(6), P. 737 - 748
Published: April 22, 2021
Several studies suggest that alcohol and cannabis co-users are heavier drinkers experience more alcohol-related consequences. However, day-level associations between co-use drinking levels mixed. One reason may be individual characteristics moderate the daily impact of using alone or in conjunction with cannabis. The theory would highly impulsive individuals drink on days, yet this assertion remains untested. Therefore, current study tested whether impulsivity moderated effect same-day quantity within veterans, a high-risk sample for substance use impulsivity.
Language: Английский
Citations
28