Photodynamic therapy combined with immunotherapy: Recent advances and future research directions DOI Creative Commons
Marta Warszyńska, Paweł Repetowski, J. Dąbrowski

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 495, P. 215350 - 215350

Published: Aug. 19, 2023

Innovative anticancer therapies based on the activation of immune system offer promise in battle against cancers resistant to traditional treatments. Examples such therapeutic approaches include, along with various types immunotherapies, photodynamic therapy (PDT). PDT is a photochemistry-based strategy that results not only from its direct effects cancer cells but also disruption tumor vasculature and host system. However, achieve success manifested eradication primary distant metastases, it necessary design suitable photosensitizers (PSs) desired optical photophysical properties enable efficient generation ROS under microenvironmental (TME) conditions, especially hypoxia. Thus, this review particular attention paid photochemical PSs, notably sufficiently long-lived triplet states mechanisms energy/electron transfer reactions. Photogenerated initiate inflammatory reaction, expression heat-shock proteins, infiltration long-term memory. These unique features give new possibilities combine agents stimulating response as well immunotherapy, PD-1/PD-L1 blockade. Most systems explored aspect so far are either derivatives naturally occurring metal complexes (Heme, Chlorophyll a, Bacteiochorophyll - inspired PSs), synthetic (metallo)porphyrins, (metallo)phthalocyanines or hybrid materials containing nanoparticles. This work summarizes recent reports synthesis antibody-PS conjugates spectroscopic enhanced selectivity biological activity. Finally, most notable drawbacks presented, scenario outlined for development alone, combined immunotherapy overcome these challenges future.

Language: Английский

The molecular machinery of regulated cell death DOI Creative Commons
Daolin Tang, Rui Kang, Tom Vanden Berghe

et al.

Cell Research, Journal Year: 2019, Volume and Issue: 29(5), P. 347 - 364

Published: April 4, 2019

Cells may die from accidental cell death (ACD) or regulated (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms have been identified are increasingly being implicated in various human pathologies. Here, we critically review the current state art regarding types RCD, including necroptosis, pyroptosis, ferroptosis, entotic death, netotic parthanatos, lysosome-dependent autophagy-dependent alkaliptosis oxeiptosis. The in-depth comprehension each these lethal subroutines their intercellular consequences uncover therapeutic targets for avoidance pathogenic loss.

Language: Английский

Citations

2000
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 DOI Creative Commons
Lorenzo Galluzzi, José Manuel Bravo‐San Pedro, Ilio Vitale

et al.

Cell Death and Differentiation, Journal Year: 2014, Volume and Issue: 22(1), P. 58 - 73

Published: Sept. 19, 2014

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such unavoidable variant cellular demise is generally referred 'accidental cell death' (ACD). In most settings, however, death initiated by genetically encoded apparatus, correlating with the fact that its course can be altered pharmacologic genetic interventions. 'Regulated (RCD) occur part physiologic programs activated once adaptive responses perturbations extracellular intracellular microenvironment fail. The biochemical phenomena accompany RCD may harnessed classify it into few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting processes are commonly thought cause RCD, such activation executioner caspases apoptosis, does exert true cytoprotective effects mammalian system, but simply alters kinetics shifts and correlates. Conversely, bona fide cytoprotection achieved transduction lethal signals early phases process, when still operational. Thus, mechanisms truly execute less understood, inhibitable perhaps more homogeneous than previously thought. Here, Nomenclature Committee on Cell Death formulates set recommendations help scientists researchers discriminate between essential accessory aspects death.

Language: Английский

Citations

919
HMGB1 in health and disease DOI
Rui Kang, Ruochan Chen, Qiuhong Zhang

et al.

Molecular Aspects of Medicine, Journal Year: 2014, Volume and Issue: 40, P. 1 - 116

Published: July 8, 2014

Language: Английский

Citations

896
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death DOI Creative Commons
Lorenzo Galluzzi, Ilio Vitale, Sarah H. Warren

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2020, Volume and Issue: 8(1), P. e000337 - e000337

Published: March 1, 2020

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular microenvironmental features determine the propensity of RCD drive immunity. Here, we provide updated operational definition immunogenic (ICD), discuss key factors that dictate ability dying cells response, summarize experimental assays are currently available for assessment ICD in vitro vivo, formulate guidelines their interpretation.

Language: Английский

Citations

855
Consensus guidelines for the detection of immunogenic cell death DOI Open Access
Oliver Kepp, Laura Senovilla, Ilio Vitale

et al.

OncoImmunology, Journal Year: 2014, Volume and Issue: 3(9), P. e955691 - e955691

Published: Sept. 2, 2014

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm system, which we named "immunogenic cell death" (ICD). ICD is preceded accompanied emission series immunostimulatory damage-associated molecular patterns (DAMPs) in precise spatiotemporal configuration. Several anticancer agents successfully employed clinic decades, including various chemotherapeutics and radiotherapy, ICD. Moreover, defects components underlie capacity system perceive death immunogenic negatively influence disease outcome among cancer patients treated with inducers. Thus, has profound clinical therapeutic implications. Unfortunately, gold-standard approach detect relies on vaccination experiments involving immunocompetent murine models syngeneic cells, an incompatible large screening campaigns. Here, outline strategies conceived surrogate markers vitro screen chemical libraries putative inducers, based high-content, high-throughput platform recently developed. Such allows detection DAMPs, like surface-exposed calreticulin, extracellular ATP high mobility group box 1 (HMGB1), and/or processes their emission, such endoplasmic reticulum stress, autophagy necrotic plasma membrane permeabilization. We surmise this technology will facilitate development next-generation regimens, kill malignant simultaneously convert them into cancer-specific vaccine.

Language: Английский

Citations

755
Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns DOI Creative Commons
Liliana Schaefer

Journal of Biological Chemistry, Journal Year: 2014, Volume and Issue: 289(51), P. 35237 - 35245

Published: Nov. 13, 2014

Language: Английский

Citations

564
The tumor suppressor protein p53 and the ferroptosis network DOI
Rui Kang, Guido Kroemer, Daolin Tang

et al.

Free Radical Biology and Medicine, Journal Year: 2018, Volume and Issue: 133, P. 162 - 168

Published: May 23, 2018

Language: Английский

Citations

546
Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein DOI Open Access
Enyong Dai, Leng Han, Jiao Liu

et al.

Autophagy, Journal Year: 2020, Volume and Issue: 16(11), P. 2069 - 2083

Published: Jan. 10, 2020

is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand effects of KRAS mutation cancer cells, direct oncogenetic activation on immune cells remain elusive. Here, we report that extracellular

Language: Английский

Citations

461
Release and activity of histone in diseases DOI Creative Commons

R Chen,

Rui Kang,

X-G Fan

et al.

Cell Death and Disease, Journal Year: 2014, Volume and Issue: 5(8), P. e1370 - e1370

Published: Aug. 14, 2014

Histones and their post-translational modifications have key roles in chromatin remodeling gene transcription. Besides intranuclear functions, histones act as damage-associated molecular pattern molecules when they are released into the extracellular space. Administration of exogenous to animals leads systemic inflammatory toxic responses through activating Toll-like receptors inflammasome pathways. Anti-histone treatment (e.g., neutralizing antibodies, activated protein C, recombinant thrombomodulin, heparin) protect mice against lethal endotoxemia, sepsis, ischemia/reperfusion injury, trauma, pancreatitis, peritonitis, stroke, coagulation, thrombosis. In addition, elevated serum histone nucleosome levels been implicated multiple pathophysiological processes progression diseases including autoimmune diseases, cancer. Therefore, could serve biomarkers novel therapeutic targets human diseases.

Language: Английский

Citations

380
Cell death due to electroporation – A review DOI Creative Commons

Tina Batista Napotnik,

Tamara Polajžer, Damijan Miklavčič

et al.

Bioelectrochemistry, Journal Year: 2021, Volume and Issue: 141, P. 107871 - 107871

Published: June 5, 2021

Exposure of cells to high voltage electric pulses increases transiently membrane permeability through electroporation. Electroporation can be reversible and is used in gene transfer enhanced drug delivery but also lead cell death. resulting death (termed as irreversible electroporation) has been successfully a new non-thermal ablation method soft tissue such tumours or arrhythmogenic heart tissue. Even though the mechanisms influence outcome electroporation-based treatments due use different pulse parameters conditions, these are not elucidated yet. We review after electroporation reported literature, injuries that may repair involved. The knowledge exposure pulses, targets field need identified optimize existing develop techniques medicine, biotechnology, food technology.

Language: Английский

Citations

349