Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across species DOI Creative Commons
Kévin Muret,

Colette Désert,

Laëtitia Lagoutte

et al.

BMC Genomics, Journal Year: 2019, Volume and Issue: 20(1)

Published: Nov. 21, 2019

Abstract Background Lipids are important for the cell and organism life since they major components of membranes, energy reserves also signal molecules. The main organs synthesis storage liver adipose tissue, both in humans more distant species such as chicken. Long noncoding RNAs (lncRNAs) known to be involved many biological processes including lipid metabolism. Results In this context, paper provides most exhaustive list lncRNAs metabolism with 60 genes identified after an in-depth analysis bibliography, while all “review” type articles a total 27 genes. These mainly described human or mice only few them have precise mode-of-action. Because these still named non-standard way making study tedious, we propose standard name according rules dictated by HUGO consortium. Moreover, about 10% which conserved between mammals chicken 2% fishes. Finally, demonstrated that two lncRNA were wrongly considered literature 3′ extensions closest coding gene. Conclusions Such catalogue can participate understanding regulators; it useful better understand genetic regulation some diseases (obesity, hepatic steatosis) traits economic interest livestock (meat quality, carcass composition). We no doubt first set will rapidly enriched coming years.

Language: Английский

Long noncoding RNA/circular noncoding RNA–miRNA–mRNA axes in cardiovascular diseases DOI
Ming Li, Liwei Duan, Yangxue Li

et al.

Life Sciences, Journal Year: 2019, Volume and Issue: 233, P. 116440 - 116440

Published: April 30, 2019

Language: Английский

Citations

120

Roles of miRNAs and long noncoding RNAs in the progression of diabetic retinopathy DOI Open Access
Qiaoyun Gong, Guanfang Su

Bioscience Reports, Journal Year: 2017, Volume and Issue: 37(6)

Published: Oct. 27, 2017

Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults across world. The pathogenesis DR multifactorial and molecular mechanisms are still not fully understood. Accumulating evidence has demonstrated that noncoding RNAs (ncRNAs) may be aberrantly expressed play vital roles development DR. Amongst ncRNAs, miRNAs long ncRNAs (lncRNAs) known for their regulatory functions. Here, we summarize functions lncRNAs Additionally, a novel lncRNA–mRNA–miRNA network included this review. We highlight original studies provide detailed data about lncRNAs, applications as diagnostic or prognostic biomarkers, potential therapeutic targets. In conclusion, review will help us gain better understanding by which perform DR, general strategies directions future research.

Language: Английский

Citations

114

Knockdown of long non-coding RNA XIST increases blood–tumor barrier permeability and inhibits glioma angiogenesis by targeting miR-137 DOI Creative Commons
Hai Yu, Yudong Xue,

P. Wang

et al.

Oncogenesis, Journal Year: 2017, Volume and Issue: 6(3), P. e303 - e303

Published: March 13, 2017

Antiangiogenic therapy plays a significant role in combined glioma treatment. However, poor permeability of the blood-tumor barrier (BTB) limits transport chemotherapeutic agents, including antiangiogenic drugs, into tumor tissues. Long non-coding RNAs (lncRNAs) have been implicated various diseases, especially malignant tumors. The present study found that lncRNA X-inactive-specific transcript (XIST) was upregulated endothelial cells were obtained BTB model vitro. XIST knockdown increased and inhibited angiogenesis. analysis mechanism action revealed reduction expression transcription factor forkhead box C1 (FOXC1) zonula occludens 2 (ZO-2) by upregulating miR-137. FOXC1 decreased increasing promoter activity ZO-1 occludin, promoted angiogenesis chemokine (C-X-C motif) receptor 7b (CXCR7). Overall, demonstrates pivotal angiogenesis, inhibition may be potential target for clinical management glioma.

Language: Английский

Citations

110

The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease DOI Creative Commons
Clarissa P. C. Gomes, Helen Spencer, K L Ford

et al.

Molecular Therapy — Nucleic Acids, Journal Year: 2017, Volume and Issue: 8, P. 494 - 507

Published: July 28, 2017

The popularization of genome-wide analyses and RNA sequencing led to the discovery that a large part human genome, while effectively transcribed, does not encode proteins. Long non-coding RNAs have emerged as critical regulators gene expression in both normal disease states. Studies long expressed heart, combination with association studies, revealed these molecules are regulated during cardiovascular development disease. Some been functionally implicated cardiac pathophysiology constitute potential therapeutic targets. Here, we review current knowledge function system, an emphasis on biology, focusing hypertension, coronary artery disease, myocardial infarction, ischemia, heart failure. We discuss implications challenges research, directions for future research translational focus.

Language: Английский

Citations

103

Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195 DOI Creative Commons
Lan Xiao, Jing Wu, Junyao Wang

et al.

Gastroenterology, Journal Year: 2017, Volume and Issue: 154(3), P. 599 - 611

Published: Oct. 16, 2017

Language: Английский

Citations

102

Role of flow-sensitive microRNAs and long noncoding RNAs in vascular dysfunction and atherosclerosis DOI
Sandeep Kumar, Darian Williams,

Sanjoli Sur

et al.

Vascular Pharmacology, Journal Year: 2018, Volume and Issue: 114, P. 76 - 92

Published: Oct. 7, 2018

Language: Английский

Citations

101

TUG1 knockdown ameliorates atherosclerosis via up-regulating the expression of miR-133a target gene FGF1 DOI
Lei Zhang, Hailing Cheng,

Yuxia Yue

et al.

Cardiovascular Pathology, Journal Year: 2017, Volume and Issue: 33, P. 6 - 15

Published: Dec. 2, 2017

Language: Английский

Citations

99

Silencing of H19 inhibits the adipogenesis and inflammation response in ox-LDL-treated Raw264.7 cells by up-regulating miR-130b DOI
Yong Nam Han, Jie Ma, Junping Wang

et al.

Molecular Immunology, Journal Year: 2017, Volume and Issue: 93, P. 107 - 114

Published: Nov. 22, 2017

Language: Английский

Citations

98

Endothelial dysfunction in diabetes and hypertension: Role of microRNAs and long non-coding RNAs DOI

Hai-na Zhang,

Xu Qiaoqiao,

Abhimanyu Thakur

et al.

Life Sciences, Journal Year: 2018, Volume and Issue: 213, P. 258 - 268

Published: Oct. 17, 2018

Language: Английский

Citations

98

Atherosclerosis and flow: roles of epigenetic modulation in vascular endothelium DOI Creative Commons
Ding-Yu Lee, Jeng‐Jiann Chiu

Journal of Biomedical Science, Journal Year: 2019, Volume and Issue: 26(1)

Published: Aug. 7, 2019

Endothelial cell (EC) dysfunctions, including turnover enrichment, gap junction disruption, inflammation, and oxidation, play vital roles in the initiation of vascular disorders atherosclerosis. Hemodynamic forces, i.e., atherprotective pulsatile (PS) pro-atherogenic oscillatory shear stress (OS), can activate mechanotransduction to modulate EC function dysfunction. This review summarizes current studies aiming elucidate epigenetic factors, histone deacetylases (HDACs), non-coding RNAs, DNA methyltransferases (DNMTs), hemodynamics-regulated OS enhances expression nuclear accumulation class I II HDACs induce dysfunction, proliferation, whereas PS induces phosphorylation-dependent export inhibit overexpression III HDAC Sirt1 enhance nitric oxide (NO) production prevent In addition, hemodynamic forces acetylation transcription retinoic acid receptor α krüppel-like factor-2, transcriptionally regulate microRNAs (miRs). OS-modulated miRs, which stimulate proliferative, pro-inflammatory, oxidative signaling, promote PS-regulated anti-proliferative, anti-inflammatory, anti-oxidative also modulates long RNAs influence function. turnover, aligmant, migration. On other hand, DNMT-1 -3a NO repression.Overall, factors modulating hemodynamic-directed dysfunction disorders, Understanding detailed mechanisms through hemodynamics-directed help us pathogenic atherosclerosis develop potential therapeutic strategies for treatment.

Language: Английский

Citations

97