BMC Genomics,
Journal Year:
2019,
Volume and Issue:
20(1)
Published: Nov. 21, 2019
Abstract
Background
Lipids
are
important
for
the
cell
and
organism
life
since
they
major
components
of
membranes,
energy
reserves
also
signal
molecules.
The
main
organs
synthesis
storage
liver
adipose
tissue,
both
in
humans
more
distant
species
such
as
chicken.
Long
noncoding
RNAs
(lncRNAs)
known
to
be
involved
many
biological
processes
including
lipid
metabolism.
Results
In
this
context,
paper
provides
most
exhaustive
list
lncRNAs
metabolism
with
60
genes
identified
after
an
in-depth
analysis
bibliography,
while
all
“review”
type
articles
a
total
27
genes.
These
mainly
described
human
or
mice
only
few
them
have
precise
mode-of-action.
Because
these
still
named
non-standard
way
making
study
tedious,
we
propose
standard
name
according
rules
dictated
by
HUGO
consortium.
Moreover,
about
10%
which
conserved
between
mammals
chicken
2%
fishes.
Finally,
demonstrated
that
two
lncRNA
were
wrongly
considered
literature
3′
extensions
closest
coding
gene.
Conclusions
Such
catalogue
can
participate
understanding
regulators;
it
useful
better
understand
genetic
regulation
some
diseases
(obesity,
hepatic
steatosis)
traits
economic
interest
livestock
(meat
quality,
carcass
composition).
We
no
doubt
first
set
will
rapidly
enriched
coming
years.
Bioscience Reports,
Journal Year:
2017,
Volume and Issue:
37(6)
Published: Oct. 27, 2017
Diabetic
retinopathy
(DR)
is
the
leading
cause
of
blindness
in
working-age
adults
across
world.
The
pathogenesis
DR
multifactorial
and
molecular
mechanisms
are
still
not
fully
understood.
Accumulating
evidence
has
demonstrated
that
noncoding
RNAs
(ncRNAs)
may
be
aberrantly
expressed
play
vital
roles
development
DR.
Amongst
ncRNAs,
miRNAs
long
ncRNAs
(lncRNAs)
known
for
their
regulatory
functions.
Here,
we
summarize
functions
lncRNAs
Additionally,
a
novel
lncRNA–mRNA–miRNA
network
included
this
review.
We
highlight
original
studies
provide
detailed
data
about
lncRNAs,
applications
as
diagnostic
or
prognostic
biomarkers,
potential
therapeutic
targets.
In
conclusion,
review
will
help
us
gain
better
understanding
by
which
perform
DR,
general
strategies
directions
future
research.
Oncogenesis,
Journal Year:
2017,
Volume and Issue:
6(3), P. e303 - e303
Published: March 13, 2017
Antiangiogenic
therapy
plays
a
significant
role
in
combined
glioma
treatment.
However,
poor
permeability
of
the
blood-tumor
barrier
(BTB)
limits
transport
chemotherapeutic
agents,
including
antiangiogenic
drugs,
into
tumor
tissues.
Long
non-coding
RNAs
(lncRNAs)
have
been
implicated
various
diseases,
especially
malignant
tumors.
The
present
study
found
that
lncRNA
X-inactive-specific
transcript
(XIST)
was
upregulated
endothelial
cells
were
obtained
BTB
model
vitro.
XIST
knockdown
increased
and
inhibited
angiogenesis.
analysis
mechanism
action
revealed
reduction
expression
transcription
factor
forkhead
box
C1
(FOXC1)
zonula
occludens
2
(ZO-2)
by
upregulating
miR-137.
FOXC1
decreased
increasing
promoter
activity
ZO-1
occludin,
promoted
angiogenesis
chemokine
(C-X-C
motif)
receptor
7b
(CXCR7).
Overall,
demonstrates
pivotal
angiogenesis,
inhibition
may
be
potential
target
for
clinical
management
glioma.
Molecular Therapy — Nucleic Acids,
Journal Year:
2017,
Volume and Issue:
8, P. 494 - 507
Published: July 28, 2017
The
popularization
of
genome-wide
analyses
and
RNA
sequencing
led
to
the
discovery
that
a
large
part
human
genome,
while
effectively
transcribed,
does
not
encode
proteins.
Long
non-coding
RNAs
have
emerged
as
critical
regulators
gene
expression
in
both
normal
disease
states.
Studies
long
expressed
heart,
combination
with
association
studies,
revealed
these
molecules
are
regulated
during
cardiovascular
development
disease.
Some
been
functionally
implicated
cardiac
pathophysiology
constitute
potential
therapeutic
targets.
Here,
we
review
current
knowledge
function
system,
an
emphasis
on
biology,
focusing
hypertension,
coronary
artery
disease,
myocardial
infarction,
ischemia,
heart
failure.
We
discuss
implications
challenges
research,
directions
for
future
research
translational
focus.
