Clinical significance of miRNAs in autoimmunity

Journal of Autoimmunity, Journal Year: 2020, Volume and Issue: 109, P. 102438 - 102438

Published: March 14, 2020

Language: Английский

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Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(24), P. 9770 - 9770

Published: Dec. 21, 2020

Damage to the tissue and ruining of functions characterize autoimmune syndromes. This review centers around leaky gut syndromes how they stimulate pathogenesis. Lymphoid commonly associated with gut, together neuroendocrine network, collaborates intestinal epithelial wall, its paracellular tight junctions, maintain balance, tolerance, resistance foreign/neo-antigens. The physiological regulator junctions plays a vital role in transferring macromolecules across barrier thereby maintains immune response equilibrium. A new paradigm has explained intricacies disease development proposed that processes can be prevented if interaction between genetic factor environmental causes is barred by re-instituting wall function. latest clinical evidence animal models reinforce this current thought offer basis for innovative methodologies thwart treat

Language: Английский

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The microbiome in autoimmune rheumatic disease

Best Practice & Research Clinical Rheumatology, Journal Year: 2020, Volume and Issue: 34(1), P. 101473 - 101473

Published: Feb. 1, 2020

Language: Английский

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Fusobacterium nucleatum promotes liver metastasis in colorectal cancer by regulating the hepatic immune niche and altering gut microbiota

Aging, Journal Year: 2022, Volume and Issue: 14(4), P. 1941 - 1958

Published: Feb. 25, 2022

Liver metastasis is the major cause of death in colorectal cancer (CRC) patients. Nevertheless, underlying mechanisms remain unknown. Gut microbiota intricately affect initiation and progression CRC by instigating immune response through secretion pro-inflammatory cytokines. In this study, we investigated contribution Fusobacterium nucleatum (F.nucleatum) to microbiota-liver axis mice, focusing on correlation between liver immunity gut alterations. When F. was orally administered evidently exaggerated accompanied noticeable deleterious effects body weight, cecum overall survival time. Further evaluation cytokine profiles revealed a substantial increase levels cytokines such as IL6, IL12, IL9, IL17A, CXCL1, MCP-1, TNF-α, IFN-γ plasma mice treated with compared that untreated control mice. Besides, hepatic also modulated recruitment myeloid-derived suppressor cells, reduction infiltration natural killer (NK) T helper-17 (Th17) well regulatory cell accumulation liver. Additionally, sustained exposure abridged murine diversity, inducing an imbalanced restructured intestinal microflora. particular, abundance CRC-promoting bacteria Enterococcus Escherichia/Shigella elevated post treatment. Thus, our findings suggest might be important factor involved promoting triggering regulation structure composition.

Language: Английский

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Type I Interferons in Autoimmunity

Journal of Investigative Dermatology, Journal Year: 2022, Volume and Issue: 142(3), P. 793 - 803

Published: Jan. 10, 2022

Language: Английский

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