Advances of computational methods enhance the development of multi-epitope vaccines DOI Creative Commons
Yiwen Wei, Tianyi Qiu,

Yisi Ai

et al.

Briefings in Bioinformatics, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 22, 2024

Vaccine development is one of the most promising fields, and multi-epitope vaccine, which does not need laborious culture processes, an attractive alternative to classical vaccines with advantage safety, efficiency. The rapid algorithms accumulation immune data have facilitated advancement computer-aided vaccine design. Here we systemically reviewed in silico resource, for different steps computational design, including immunogen selection, epitope prediction, construction, optimization, evaluation. performance available tools on prediction immunogenicity evaluation was tested compared benchmark datasets. Finally, discuss future research direction construction a multiepitope vaccine.

Language: Английский

Advances in nucleic acid-based cancer vaccines DOI Creative Commons
Hung‐Chun Liao, Shih‐Jen Liu

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: Jan. 21, 2025

Abstract Nucleic acid vaccines have emerged as crucial advancements in vaccine technology, particularly highlighted by the global response to COVID-19 pandemic. The widespread administration of mRNA against billions globally marks a significant milestone. Furthermore, approval an for Respiratory Syncytial Virus (RSV) this year underscores versatility technology. In oncology, combination encoding neoantigens and immune checkpoint inhibitors (ICIs) has shown remarkable efficacy eliciting protective responses diseases like melanoma pancreatic cancer. Although use DNA been limited India, inherent stability at room temperature cost-effectiveness present viable option that could benefit developing countries. These advantages may help address some challenges associated with vaccines. Currently, several trials are exploring DNA-encoded ICIs across various cancer types. studies highlight promising role nucleic acid-based next generation immunotherapeutic agents treatment. This review will delve into recent current developmental status both DNA-based

Language: Английский

Citations

5
Circular RNAs in tumor immunity and immunotherapy DOI Creative Commons
Wenjie Zhang, Xu Chen, Zhipeng Yang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 21, 2024

Circular RNAs (circRNAs) are unique noncoding that have a closed and stable loop structure generated through backsplicing. Due to their conservation, stability tissue specificity, circRNAs can potentially be used as diagnostic indicators therapeutic targets for certain tumors. Many studies shown act microRNA (miRNA) sponges, engage in interactions with proteins translation templates regulate gene expression signal transduction, thereby participating the occurrence development of variety malignant Immunotherapy has revolutionized treatment cancer. Early researches indicated involved regulating tumor immune microenvironment antitumor immunity. CircRNAs may potential important increasing sensitivity immunotherapy expanding population patients who benefit from cancer immunotherapy. However, few investigated correlation between In this review, we summarize current on regulation different mechanisms value efficacy goal providing new

Language: Английский

Citations

10
Enhancing immunogenicity and release of in situ-generated tumor vesicles for autologous vaccines DOI
Jinhu Chen,

Caili Zhao,

Jing Zhang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113614 - 113614

Published: March 1, 2025

Language: Английский

Citations

1
Peptide hydrogel platform encapsulating manganese ions and high-density lipoprotein nanoparticle-mimicking nanovaccines for the prevention and treatment of gastric cancer DOI Creative Commons
Xu Huang, Hong Lin,

Yufan Lv

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 25, 2025

Advanced gastric cancer remains a significant global health challenge, with limited therapeutic options available. In contrast, immunotherapy have emerged as promising alternatives, offering greater potency in treating advanced cancer. However, the development of novel and efficient immunotherapeutic strategy is crucial to enhance body's immune response against This study developed single-injection peptide hydrogel-based nanovaccine therapy for treatment. The utilizes RADA32 hydrogel, which sensitive metal ion concentration, encapsulate manganese ions HPPS nanovaccines. nanovaccines contain antigen CpG-ODN, designed activate both toll-like receptor 9 (TLR9) cGAS-STING signaling pathways antigen-presenting cells. design aims facilitate stable sustained release nanovaccine, thereby enhancing effective recognition antigens. efficacy system was confirmed using model OVA cancer-specific MG7-related peptide. results demonstrated that effectively activated response, leading enhanced activation TLR9 cells observed highlighting potential this approach stimulate robust presents clinical anti-tumor vaccine administration, prevention treatment provides convenient method could potentially be expanded other types cancer, providing versatile platform immunotherapy.

Language: Английский

Citations

0
Cancer Nanovaccines: Mechanisms, Design Principles, and Clinical Translation DOI Creative Commons

Gabriel de Camargo Zaccariotto,

Maria Julia Bistaffa, Angelica Maria Mazuera Zapata

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Cancer immunotherapy has transformed the landscape of oncological treatment by employing various strategies to teach immune system eliminate tumors. Among these, cancer nanovaccines are an emerging strategy that utilizes nanotechnology enhance activation in response tumor antigens. This review addresses principles behind different technologies this field aimed at generating a robust and effective response. The diversity adopted for design is discussed, including types active agents, nanocarriers, their functionalizations, incorporation adjuvants. Furthermore, optimize nanoparticle formulations antigen presentation, target cells, organs promote strong durable antitumor responses explored. Finally, we analyze current state clinical application, highlighting ongoing trials future potential nanovaccines. insights presented aim guide research development efforts field, contributing advancement more targeted fight against cancer.

Language: Английский

Citations

0
Prospects and challenges of neoantigen applications in oncology DOI
Ranran Shi,

Ling Ran,

Yuan Tian

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113329 - 113329

Published: Oct. 14, 2024

Language: Английский

Citations

2
Peptide hydrogel platform encapsulating manganese ions and high-density lipoprotein nanoparticle-mimicking nanovaccines for the prevention and treatment of gastric cancer DOI Creative Commons
Xu Huang, Hong Lin,

Yufan Lv

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract While chemotherapy and radiotherapy may alleviate symptoms prolong survival in patients with advanced gastric cancer, their efficacy is constrained. In contrast, immunotherapies, including immune checkpoint inhibitors, T-cell transfer therapy, therapeutic vaccines, demonstrate greater potency treating cancer. This study developed a single-injection peptide hydrogel-based nanovaccine therapy for cancer treatment. The employs RADA32 hydrogel, sensitive to metal ion concentration, encapsulating manganese ions HPPS nanovaccines (containing antigen peptides CpG-ODN) facilitate stable, sustained release of the nanovaccine. strategy activates both toll-like receptor 9 cGAS-STING signaling pathways antigen-presenting cells, enhancing body's effective recognition response antigens. system's was confirmed using model OVA cancer-specific MG7-related peptide. approach offers novel clinical anti-tumor vaccine administration be applicable preventing

Language: Английский

Citations

1
Vaccins, facteurs de progrès médicaux et scientifiques1 DOI

Yvon Lebranchu

Bulletin de l Académie Nationale de Médecine, Journal Year: 2024, Volume and Issue: 208(9), P. 1251 - 1253

Published: Oct. 5, 2024

Citations

0
Advances of computational methods enhance the development of multi-epitope vaccines DOI Creative Commons
Yiwen Wei, Tianyi Qiu,

Yisi Ai

et al.

Briefings in Bioinformatics, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 22, 2024

Vaccine development is one of the most promising fields, and multi-epitope vaccine, which does not need laborious culture processes, an attractive alternative to classical vaccines with advantage safety, efficiency. The rapid algorithms accumulation immune data have facilitated advancement computer-aided vaccine design. Here we systemically reviewed in silico resource, for different steps computational design, including immunogen selection, epitope prediction, construction, optimization, evaluation. performance available tools on prediction immunogenicity evaluation was tested compared benchmark datasets. Finally, discuss future research direction construction a multiepitope vaccine.

Language: Английский

Citations

0