Advancing the next generation of cancer treatment with circular RNAs in CAR-T cell therapy DOI Open Access

Sanxiong Huang,

Juling Xu,

Natalia Baran

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117753 - 117753

Published: Dec. 1, 2024

Chimeric Antigen Receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematological malignancies. However, its effectiveness against solid tumors remains constrained by challenges such as exhaustion, limited persistence, and off-target effects. These highlight critical gaps in current CAR-T cell therapeutic strategies, particularly for tumor applications. Circular RNAs (circRNAs) represent a transformative class non-coding RNAs, known their exceptional stability precise regulatory functions, positioning them promising candidates enhancing next-generation therapies. Notably, circRNAs can bridge gap between preclinical research clinical application offering innovative solutions to overcome technical hurdles improve outcomes. Despite potential, remain underexplored therapies tumors, presenting significant opportunity innovation. The mechanisms through which modulate specificity are not yet fully understood, challenges, achieving efficient targeted circRNA delivery, still need be addressed. This review highlights importance integrating into enhance specificity, minimize effects, durability. By emphasizing potential identifying key gaps, this provides roadmap advancing setting stage next generation personalized cancer treatments.

Language: Английский

GC-derived exosomal circMAN1A2 promotes cancer progression and suppresses T-cell antitumour immunity by inhibiting FBXW11-mediated SFPQ degradation DOI Creative Commons
Yikai Shen, Jie Lin,

Tianlu Jiang

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 25, 2025

Abstract Background Exosomes, as extracellular membrane vesicles, play important roles in intercellular communication and can influence tumour progression. Circular RNAs (circRNAs) have been reported various malignancies are also components of exosomes. However, the role exosomal circRNAs gastric cancer (GC) progression has not completely clarified. Methods The enriched GC were identified using circRNA sequencing. biological function circMAN1A2 was investigated a series vitro vivo experiments. PKH-67 staining used to label molecular mechanism via mass spectrometry, immunoprecipitation, Western blot, single-cell RNA-sequencing data analyses. Results In our study, we determined that (hsa_circ_0000118) GC-derived Higher expression related poor survival patients (HR = 2.917, p 0.0120). Exosomal promoted suppressed antitumour activity T cells. Moreover, bound SFPQ cells cells, promoting G1/S phase transition cell cycle while inhibiting activation receptor signalling pathway decrease activity. Mechanistically, competed with FBXW11 for binding SFPQ, preventing FBXW11-mediated k48-linked ubiquitination protein degradation, thereby stabilizing expression. Conclusions Our work confirms critical immunosuppression GC. This novel axis circMAN1A2-SFPQ provides new insights into circRNA-based diagnostic therapeutic strategies.

Language: Английский

Citations

2
A new paradigm for cancer immunotherapy: targeting immunogenic cell death-related noncoding RNA DOI Creative Commons

Guojuan Sun,

Ling He

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 23, 2025

Cancer immunotherapy has shown significant potential in treating several malignancies by stimulating the host immune system to recognize and attack cancer cells. Immunogenic cell death (ICD) can amplify antitumor responses reverse immunosuppressive tumor microenvironment, thus increasing sensitivity of immunotherapy. In recent years, noncoding RNAs (ncRNAs) have emerged as key regulatory factors ICD oncologic immunity. Accordingly, ICD-related ncRNAs hold promise novel therapeutic targets for optimizing efficacy However, immunomodulatory properties not yet been comprehensively summarized. Hence, we summarize current knowledge on involved their roles this review. It deepens our understanding associated with provides a new strategy enhance specifically targeting ncRNAs.

Language: Английский

Citations

0
Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential DOI Creative Commons

Shiming Tan,

Wenjuan Yang, Zongyao Ren

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 19, 2025

In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing particularly promising avenue investigation. The identification ncRNA-encoded in human cancers is increasing. These regulate cancer progression through multiple molecular mechanisms. Here, we delineate patterns diverse and provide synopsis methodologies employed for that possess capacity to encode these peptides. Furthermore, discuss impacts on biological behavior cells underlying conclusion, describe prospects challenges need be overcome.

Language: Английский

Citations

0
Effects of circulating RNAs on tumor metabolism in lung cancer (Review) DOI Open Access

Pengfei Zhao,

Zhengfeng Zhu, Xi Zheng

et al.

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(4), P. 1 - 11

Published: Feb. 27, 2025

During the development and progression of lung cancer, cell metabolism function is altered. Thus, cells rely on aerobic glycolysis abnormal lipid amino acid to obtain energy nutrients for growth, proliferation drug resistance. Circular RNAs (circRNAs), a class non-coding RNAs, serve important biological roles in growth tumors. Functionally, circRNAs act as molecular sponges that absorb microRNAs (miRNAs) RNA-binding proteins protein scaffolds regulate gene transcription translation through maintenance mRNA stability. In addition, are regulators tumor promote mediating proliferation, metastasis induction chemoresistance. Results previous studies reveal may key role regulating metabolic processes miRNA sponging alternative mechanisms. demonstrate potential therapeutic targets cancer. The present study aimed review effects cancer provide novel insights into clinical treatment also theoretical basis targets.

Language: Английский

Citations

0
miR‐135b: A Potential Biomarker for Pathological Diagnosis and Biological Therapy DOI
Dezhi Yan,

Qingliu He,

Chunjian Wang

et al.

Wiley Interdisciplinary Reviews - RNA, Journal Year: 2025, Volume and Issue: 16(2)

Published: March 1, 2025

ABSTRACT MicroRNAs (miRNAs) are a class of endogenous non‐coding RNAs found in eukaryotes with post‐transcriptional regulatory functions. A variety miRNAs is differentially expressed cancer tissues and thus can be used as biomarkers. microRNA‐135b‐5p (miR‐135b) has been shown to involved the pathological processes neoplastic non‐neoplastic diseases. Under different conditions, miR‐135b tumor suppressive carcinogenic effects. regulates development cancer, including metabolism, proliferation, apoptosis, invasion, fibrosis, angiogenesis, immunomodulation, drug resistance. new biomarker for diagnosis prognosis, which potential clinical guidance. This article reviews relevant research on miR‐135B field tumors, biogenesis background miR‐135b, expression related targets signaling pathways mediating progression order sort out explore transformation value miR‐135b.

Language: Английский

Citations

0
Non-coding RNAs: emerging biomarkers and therapeutic targets in cancer and inflammatory diseases DOI Creative Commons
Basma Hossam Abdelmonem,

Lereen T. Kamal,

Lilian Waheed Wardy

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 10, 2025

Non-coding RNAs (ncRNAs) have a significant role in gene regulation, especially cancer and inflammatory diseases. ncRNAs, such as microRNA, long non-coding RNAs, circular alter the transcriptional, post-transcriptional, epigenetic expression levels. These molecules act biomarkers possible therapeutic targets because aberrant ncRNA has been directly connected to tumor progression, metastasis, response therapy research. ncRNAs’ interactions with multiple cellular pathways, including MAPK, Wnt, PI3K/AKT/mTOR, impact processes like proliferation, apoptosis, immune responses. The potential of RNA-based therapeutics, anti-microRNA microRNA mimics, restore normal is being actively studied. Additionally, tissue-specific patterns ncRNAs offer unique opportunities for targeted therapy. Specificity, stability, responses are obstacles use ncRNAs; however, novel strategies, modified oligonucleotides delivery systems, developed. profiling may result more individualized successful treatments precision medicine advances, improving patient outcomes creating early diagnosis monitoring opportunities. current review aims investigate roles diseases, focusing on their mechanisms regulation implications non-invasive diagnostics therapies. A comprehensive literature was conducted using PubMed Google Scholar, research published between 2014 2025. Studies were selected based rigorous inclusion criteria, peer-reviewed status relevance Non-English, non-peer-reviewed, inconclusive studies excluded. This approach ensures that findings presented high-quality relevant sources.

Language: Английский

Citations

0
Periprosthetic osteolysis: Mechanisms and potential treatment strategies DOI
Fang Yao,

Yongneng Bao,

Qian Meng

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111758 - 111758

Published: March 1, 2025

Language: Английский

Citations

0
Circular RNA vaccines: Pioneering the next-gen cancer immunotherapy DOI Creative Commons
Uddalak Das, Soupayan Banerjee,

Meghna Sarkar

et al.

Cancer Pathogenesis and Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

2
Advancing the next generation of cancer treatment with circular RNAs in CAR-T cell therapy DOI Open Access

Sanxiong Huang,

Juling Xu,

Natalia Baran

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117753 - 117753

Published: Dec. 1, 2024

Chimeric Antigen Receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematological malignancies. However, its effectiveness against solid tumors remains constrained by challenges such as exhaustion, limited persistence, and off-target effects. These highlight critical gaps in current CAR-T cell therapeutic strategies, particularly for tumor applications. Circular RNAs (circRNAs) represent a transformative class non-coding RNAs, known their exceptional stability precise regulatory functions, positioning them promising candidates enhancing next-generation therapies. Notably, circRNAs can bridge gap between preclinical research clinical application offering innovative solutions to overcome technical hurdles improve outcomes. Despite potential, remain underexplored therapies tumors, presenting significant opportunity innovation. The mechanisms through which modulate specificity are not yet fully understood, challenges, achieving efficient targeted circRNA delivery, still need be addressed. This review highlights importance integrating into enhance specificity, minimize effects, durability. By emphasizing potential identifying key gaps, this provides roadmap advancing setting stage next generation personalized cancer treatments.

Language: Английский

Citations

1