The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice DOI Creative Commons
Peng Zheng, Benhua Zeng, Meiling Liu

et al.

Science Advances, Journal Year: 2019, Volume and Issue: 5(2)

Published: Feb. 1, 2019

Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated medicated patients SCZ had decreased α-diversity index marked disturbances of microbial composition versus healthy controls (HCs). Several unique bacterial taxa (e.g., Veillonellaceae Lachnospiraceae) were associated severity. A specific panel (Aerococcaceae, Bifidobacteriaceae, Brucellaceae, Pasteurellaceae, Rikenellaceae) enabled discriminating from HCs 0.769 area under curve. Compared to HCs, germ-free mice receiving fecal transplants lower glutamate higher glutamine GABA in hippocampus displayed SCZ-relevant similar other mouse models involving glutamatergic hypofunction. Together, our findings suggest itself alter neurochemistry neurologic ways may be relevant pathology.

Language: Английский

The Microbiota-Gut-Brain Axis DOI Open Access
John F. Cryan, Kenneth J. O’Riordan, Caitlin S.M. Cowan

et al.

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 1877 - 2013

Published: Aug. 28, 2019

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric

Language: Английский

Citations

3470
Current understanding of the human microbiome DOI
Jack A. Gilbert, Martin J. Blaser, J. Gregory Caporaso

et al.

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(4), P. 392 - 400

Published: April 1, 2018

Language: Английский

Citations

2142
Interactions between the microbiota, immune and nervous systems in health and disease DOI
Thomas C. Fung, C. Anders Olson, Elaine Y. Hsiao

et al.

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(2), P. 145 - 155

Published: Jan. 16, 2017

Language: Английский

Citations

1579
The neuroactive potential of the human gut microbiota in quality of life and depression DOI
Mireia Valles‐Colomer, Gwen Falony, Youssef Darzi

et al.

Nature Microbiology, Journal Year: 2019, Volume and Issue: 4(4), P. 623 - 632

Published: Feb. 4, 2019

Language: Английский

Citations

1558
The gut microbiota–brain axis in behaviour and brain disorders DOI
Lívia H. Morais, Henry L. Schreiber, Sarkis K. Mazmanian

et al.

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(4), P. 241 - 255

Published: Oct. 22, 2020

Language: Английский

Citations

1472
The Bidirectional Relationship of Depression and Inflammation: Double Trouble DOI Creative Commons
Eléonore Beurel, Marisa Toups, Charles B. Nemeroff

et al.

Neuron, Journal Year: 2020, Volume and Issue: 107(2), P. 234 - 256

Published: June 17, 2020

Language: Английский

Citations

1434
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat DOI
John R. Kelly,

Yuliya Borre,

Ciaran O' Brien

et al.

Journal of Psychiatric Research, Journal Year: 2016, Volume and Issue: 82, P. 109 - 118

Published: July 26, 2016

Language: Английский

Citations

1406
Gut microbiota dysbiosis contributes to the development of hypertension DOI Creative Commons
Jing Li, Fangqing Zhao, Yidan Wang

et al.

Microbiome, Journal Year: 2017, Volume and Issue: 5(1)

Published: Feb. 1, 2017

Recently, the potential role of gut microbiome in metabolic diseases has been revealed, especially cardiovascular diseases. Hypertension is one most prevalent worldwide, yet whether microbiota dysbiosis participates development hypertension remains largely unknown. To investigate this issue, we carried out comprehensive metagenomic and metabolomic analyses a cohort 41 healthy controls, 56 subjects with pre-hypertension, 99 individuals primary hypertension, performed fecal transplantation from patients to germ-free mice.Compared found dramatically decreased microbial richness diversity, Prevotella-dominated enterotype, distinct composition reduced bacteria associated status overgrowth such as Prevotella Klebsiella, disease-linked function both pre-hypertensive hypertensive populations. Unexpectedly, characteristic pre-hypertension group was quite similar that hypertension. The metabolism changes host or were identified be closely linked dysbiosis. And disease classifier based on metabolites constructed discriminate controls accurately. Furthermore, by human donors mice, elevated blood pressure observed transferrable through microbiota, direct influence demonstrated.Overall, our results describe novel causal aberrant contributing pathogenesis significance early intervention for emphasized.

Language: Английский

Citations

1389
The Central Nervous System and the Gut Microbiome DOI Creative Commons
Gil Sharon, Timothy R. Sampson, Daniel H. Geschwind

et al.

Cell, Journal Year: 2016, Volume and Issue: 167(4), P. 915 - 932

Published: Nov. 1, 2016

Language: Английский

Citations

1249
The Controversial Role of Human Gut Lachnospiraceae DOI Creative Commons
Mirco Vacca, Giuseppe Celano, Francesco Maria Calabrese

et al.

Microorganisms, Journal Year: 2020, Volume and Issue: 8(4), P. 573 - 573

Published: April 15, 2020

The complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core microbiota, colonizing intestinal lumen from birth increasing, terms species richness their relative abundances during host's life. Although, members are among main producers short-chain fatty acids, different taxa also associated with intra- extraintestinal diseases. Their impact on host physiology is often inconsistent across studies. Here, we discuss changes according With aim harnessing promote health, analyze how nutrients diet can influence growth metabolites can, turn, physiology.

Language: Английский

Citations

1198