CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Nature Immunology, Journal Year: 2020, Volume and Issue: 21(3), P. 298 - 308

Published: Feb. 17, 2020

Language: Английский

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Regulation and metabolic functions of mTORC1 and mTORC2

Physiological Reviews, Journal Year: 2021, Volume and Issue: 101(3), P. 1371 - 1426

Published: Feb. 18, 2021

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth proliferation. The uptake of from the environment their intracellular metabolism is a highly controlled process that involves cross talk between signaling metabolic pathways. Despite constant fluctuations in nutrient availability environmental signals, normal cells restore homeostasis maintain cellular functions prevent disease. A central molecule integrates with mechanistic target rapamycin (mTOR). mTOR protein kinase responds levels signals. forms two complexes, mTORC1, which sensitive rapamycin, mTORC2, not directly inhibited by this drug. Rapamycin has facilitated discovery various mTORC1 metabolism. Genetic models disrupt either or mTORC2 have expanded our knowledge cellular, tissue, as well systemic Nevertheless, regulation particularly metabolism, lagged behind. Since an important cancer, aging, other metabolism-related pathologies, understanding distinct overlapping complexes vital development more effective therapeutic strategies. This review discusses key discoveries recent findings on complexes. We highlight cancer but also discuss examples mTOR-mediated reprogramming occurring stem immune cells, type 2 diabetes/obesity, neurodegenerative disorders, aging.

Language: Английский

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Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

Nature Immunology, Journal Year: 2016, Volume and Issue: 17(12), P. 1459 - 1466

Published: Oct. 3, 2016

Language: Английский

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The regulation of immune tolerance by FOXP3

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 17(11), P. 703 - 717

Published: July 31, 2017

Language: Английский

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Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(3), P. 149 - 163

Published: Feb. 15, 2016

Language: Английский

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A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

Cell Reports, Journal Year: 2016, Volume and Issue: 15(10), P. 2136 - 2146

Published: May 28, 2016

Dietary interventions have not been effective in the treatment of multiple sclerosis (MS). Here, we show that periodic 3-day cycles a fasting mimicking diet (FMD) are ameliorating demyelination and symptoms murine experimental autoimmune encephalomyelitis (EAE) model. The FMD reduced clinical severity all mice completely reversed 20% animals. These improvements were associated with increased corticosterone levels regulatory T (Treg) cell numbers pro-inflammatory cytokines, TH1 TH17 cells, antigen-presenting cells (APCs). Moreover, promoted oligodendrocyte precursor regeneration remyelination axons both EAE cuprizone MS models, supporting its effects on suppression autoimmunity remyelination. We also report preliminary data suggesting an or chronic ketogenic safe, feasible, potentially relapsing-remitting (RRMS) patients (NCT01538355).

Language: Английский

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T cell receptor signalling in the control of regulatory T cell differentiation and function

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(4), P. 220 - 233

Published: March 30, 2016

Language: Английский

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Homeostatic control of regulatory T cell diversity

Nature reviews. Immunology, Journal Year: 2014, Volume and Issue: 14(3), P. 154 - 165

Published: Jan. 31, 2014

Language: Английский

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Helper T cell differentiation

Cellular and Molecular Immunology, Journal Year: 2019, Volume and Issue: 16(7), P. 634 - 643

Published: March 12, 2019

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Metabolic pathways in T cell activation and lineage differentiation

Seminars in Immunology, Journal Year: 2016, Volume and Issue: 28(5), P. 514 - 524

Published: Oct. 1, 2016

Recent advances in the field of immunometabolism support concept that fundamental processes T cell biology, such as TCR-mediated activation and helper lineage differentiation, are closely linked to changes cellular metabolic programs. Although major task intermediate metabolism is provide with a constant supply energy molecular precursors for production biomolecules, dynamic regulation pathways also plays an active role shaping responses. Key glycolysis, fatty acid mitochondrial now recognized crucial players their modulation can differentially affect development lineages. In this review, we describe diverse cells engage during life cycle from naïve towards effector memory cells. We consider particular how may actively function different states. Moreover, discuss regulators mTOR or AMPK link environmental adaptations elucidate consequences on differentiation function.

Language: Английский

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