Cancer across the tree of life: cooperation and cheating in multicellularity DOI Creative Commons
Athena Aktipis,

Amy M. Boddy,

Gunther Jansen

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2015, Volume and Issue: 370(1673), P. 20140219 - 20140219

Published: June 10, 2015

Multicellularity is characterized by cooperation among cells for the development, maintenance and reproduction of multicellular organism. Cancer can be viewed as cheating within this cooperative system. Complex multicellularity, underlying it, has evolved independently multiple times. We review existing literature on cancer cancer-like phenomena across life, not only focusing complex multicellularity but also reviewing tree life more broadly. find that a breakdown central features characterize including in proliferation inhibition, cell death, division labour, resource allocation extracellular environment (which we term five foundations multicellularity). Cheating exhibited lack differentiation disorganized masses, been observed all forms multicellularity. This suggests deregulation fundamental universal aspect carcinogenesis may underappreciated biology. Understanding provides novel insights into hallmarks set assays biomarkers applied species requirements generating cancer.

Language: Английский

Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations DOI
Jesse J. Salk,

Michael W. Schmitt,

Lawrence A. Loeb

et al.

Nature Reviews Genetics, Journal Year: 2018, Volume and Issue: 19(5), P. 269 - 285

Published: March 26, 2018

Language: Английский

Citations

463
“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy DOI Creative Commons

Jessica A. Kemp,

Min Suk Shim, Chan Yeong Heo

et al.

Advanced Drug Delivery Reviews, Journal Year: 2015, Volume and Issue: 98, P. 3 - 18

Published: Nov. 4, 2015

Language: Английский

Citations

461
Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map DOI
Jennifer Huynh, Ashwini L. Chand, Daniel J. Gough

et al.

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 19(2), P. 82 - 96

Published: Dec. 21, 2018

Language: Английский

Citations

451
Extracellular vesicles: masters of intercellular communication and potential clinical interventions DOI Open Access

Jonathan M. Pitt,

Guido Kroemer, Laurence Zitvogel

et al.

Journal of Clinical Investigation, Journal Year: 2016, Volume and Issue: 126(4), P. 1139 - 1143

Published: March 31, 2016

Intercellular signaling via extracellular vesicles (EVs) is an underappreciated modality of cell-cell crosstalk that enables cells to convey packages complex instructions specific recipient cells. EVs transmit these through their cargoes multiple proteins, nucleic acids, and specialized lipids, which are derived from origin allow for combinatorial effects upon This Review series brings together the recent progress in our understanding EV physiological pathophysiological conditions, highlighting how certain EVs, particularly exosomes, can promote or regulate infections, host immune responses, development, various diseases - notably cancer. Given diverse nature abilities profoundly modulate cells, this puts particular emphasis on clinical applications as therapeutics diagnostic biomarkers.

Language: Английский

Citations

446
Cancer across the tree of life: cooperation and cheating in multicellularity DOI Creative Commons
Athena Aktipis,

Amy M. Boddy,

Gunther Jansen

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2015, Volume and Issue: 370(1673), P. 20140219 - 20140219

Published: June 10, 2015

Multicellularity is characterized by cooperation among cells for the development, maintenance and reproduction of multicellular organism. Cancer can be viewed as cheating within this cooperative system. Complex multicellularity, underlying it, has evolved independently multiple times. We review existing literature on cancer cancer-like phenomena across life, not only focusing complex multicellularity but also reviewing tree life more broadly. find that a breakdown central features characterize including in proliferation inhibition, cell death, division labour, resource allocation extracellular environment (which we term five foundations multicellularity). Cheating exhibited lack differentiation disorganized masses, been observed all forms multicellularity. This suggests deregulation fundamental universal aspect carcinogenesis may underappreciated biology. Understanding provides novel insights into hallmarks set assays biomarkers applied species requirements generating cancer.

Language: Английский

Citations

423