Recent progress in drug delivery

Acta Pharmaceutica Sinica B, Journal Year: 2019, Volume and Issue: 9(6), P. 1145 - 1162

Published: Aug. 19, 2019

Drug delivery systems (DDS) are defined as methods by which drugs delivered to desired tissues, organs, cells and subcellular organs for drug release absorption through a variety of carriers. Its usual purpose improve the pharmacological activities therapeutic overcome problems such limited solubility, aggregation, low bioavailability, poor biodistribution, lack selectivity, or reduce side effects drugs. During 2015–2018, significant progress in research on has been achieved along with advances related fields, pharmaceutical sciences, material sciences biomedical sciences. This review provides concise overview current this area its focus strategies, construction techniques specific examples. It is valuable reference scientists who want learn more about design systems.

Language: Английский

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Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy

Small, Journal Year: 2018, Volume and Issue: 15(1)

Published: Nov. 20, 2018

Abstract Phototherapy including photothermal therapy (PTT) and photodynamic (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional include easy recognition immune system, rapid clearance from blood circulation, low accumulation in target sites. Cell‐membrane coating emerged as a potential way overcome these limitations, owing abundant proteins on surface of cell membranes that can be inherited membrane–camouflaged nanoparticles. This review summarizes recent advances development biomimetic nanoparticles phototherapy. Different sources used coat uisng different approaches. After cell‐membrane coating, photophysical properties original remain nearly unchanged; however, coated are equipped with additional physiological features escape, vivo prolonged circulation time, homologous targeting, depending sources. Moreover, membrane ablated under laser irradiation, leading drug release thus synergetic By combining other supplementary normalize tumor microenvironment, further enhance therapeutic efficacy against cancer.

Language: Английский

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Recent progress in nanomedicine for enhanced cancer chemotherapy

Theranostics, Journal Year: 2021, Volume and Issue: 11(13), P. 6370 - 6392

Published: Jan. 1, 2021

As one of the most important cancer treatment strategies, conventional chemotherapy has substantial side effects and leads easily to failure. Therefore, exploring developing more efficient methods enhance is an urgently problem that must be solved. With development nanotechnology, nanomedicine showed a good application prospect in improving chemotherapy. In this review, we aim present discussion on significant research progress for enhanced First, increased enrichment drugs tumor tissues relying different targeting ligands promoting tissue penetration are summarized. Second, specific subcellular organelle-targeted discussed. Next, combinational strategies reverse multidrug resistance (MDR) improve effective intracellular concentration therapeutics Furthermore, advantages combination therapy emphasized. Finally, discuss major problems facing therapeutic chemotherapy, propose possible future directions field.

Language: Английский

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Nanomedicines for Reactive Oxygen Species Mediated Approach: An Emerging Paradigm for Cancer Treatment

Accounts of Chemical Research, Journal Year: 2019, Volume and Issue: 52(7), P. 1771 - 1782

Published: June 26, 2019

ConspectusGrowth in the knowledge of cancer biology has led to emergence and evolution nanomedicines by providing rationale for leveraging nanotechnology develop better treatment options. The discovery nanometer-sized intercellular openings defective angiogenic tumor vasculature contributed development an idea well-known passive targeting regime, enhanced permeability retention (EPR) effect, nanomedicines. Recently, reactive oxygen species (ROS) have been highlighted as one key players that underlie acquisition various hallmarks cancer. As ROS are associated with all stages cancer, their applications based on following concentration-dependent implications attracted much attention: (1) low moderate levels signaling molecules, (2) elevated cells unique characteristics (3) excessive cytotoxic agents. Considering from a different point view, designed achieve spatiotemporal control therapeutic action, main research focus this area.This Account includes our efforts preclinical achievements range ROS-mediated therapies. It begins general background regarding nanomedicines, significance brief overview approaches therapy. Then, highlights two roles define purposes nanomedicines: drug delivery enhancers cell death inducers. former inspired us nitric oxide-generating nanoparticles improved EPR endogenous ROS-responsive polymeric micelles intracellular delivery, exogenous ROS-activated subcellular localization via photochemical internalization. While refining conventional chemotherapy, recent researches also focused latter, ROS, advance alternative modalities such oxidation therapy, photodynamic therapy (PDT), sonodynamic (SDT). In particular, we motivated nanoreactors containing enzymes produce H2O2 photosensitizer-loaded gold-nanoclustered nanoassemblies photothermally activated PDT overcoming dependency PDT, hydrophilized TiO2 Au-TiO2 nanocomposites novel sonosensitizers SDT efficiency. integration nanomedicine emerged new paradigm promising proof-of-concept demonstrations studies. Further ensure clinical translation along more sophisticated address relevant challenges expected be made coming years.

Language: Английский

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Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials

Advanced Materials, Journal Year: 2018, Volume and Issue: 31(3)

Published: Sept. 10, 2018

Abstract Recently, diverse functional materials that take subcellular structures as therapeutic targets are playing increasingly important roles in cancer therapy. Here, particular emphasis is placed on four kinds of therapies, including chemotherapy, gene therapy, photodynamic therapy (PDT), and hyperthermal which the most widely used approaches for killing cells by specific destruction organelles. Moreover, some non‐drug‐loaded nanoformulations (i.e., metal nanoparticles molecular self‐assemblies) with a fatal effect influencing functions without use any drug molecules also included. According to basic principles unique performances each treatment, appropriate strategies developed meet task‐specific applications integrating materials, ligands, well methods. In addition, combination two or more therapies based multifunctional nanostructures, either directly target organelles release organelle‐targeted therapeutics, introduced intent superadditive effects. Finally, related challenges critical re‐evaluation this emerging field presented.

Language: Английский

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Graphene‐Based Smart Platforms for Combined Cancer Therapy

Advanced Materials, Journal Year: 2018, Volume and Issue: 31(9)

Published: July 24, 2018

The extensive research of graphene and its derivatives in biomedical applications during the past few years has witnessed significance field nanomedicine. Starting from simple drug delivery systems, application been extended to a versatile platform multiple therapeutic modalities, including photothermal therapy, photodynamic magnetic hyperthermia sonodynamic therapy. In addition monotherapy, graphene-based materials are widely applied combined therapies for enhanced anticancer activity reduced side effects. particular, often designed fabricated as "smart" platforms stimuli-responsive nanocarriers, whose effects can be activated by tumor microenvironment, such acidic pH elevated glutathione (termed "endogenous stimuli"), or light, magnetic, ultrasonic stimuli "exogenous stimuli"). Herein, recent advances smart therapy presented, starting with principle design applications. Next, contributed materials, chemotherapy-based, photothermal-therapy-based, ultrasound-therapy-based synergistic outlined. addition, current challenges future prospects regarding this promising discussed.

Language: Английский

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Targeted nanomedicine for cancer therapeutics: Towards precision medicine overcoming drug resistance

Drug Resistance Updates, Journal Year: 2017, Volume and Issue: 31, P. 15 - 30

Published: March 1, 2017

Language: Английский

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Supramolecular “Trojan Horse” for Nuclear Delivery of Dual Anticancer Drugs

Journal of the American Chemical Society, Journal Year: 2017, Volume and Issue: 139(8), P. 2876 - 2879

Published: Feb. 13, 2017

Nuclear delivery and accumulation are very important for many anticancer drugs that interact with DNA or its associated enzymes in the nucleus. However, it is difficult neutrally negatively charged such as 10-hydroxycamptothecine (HCPT). Here we report a simple strategy to construct supramolecular nanomedicines nuclear of dual synergistic drugs. Our utilizes coassembly HCPT-peptide amphiphile positively cisplatin. The resulting nanomaterials behave "Trojan Horse" transported soldiers (anticancer drugs) across walls castle (cell nucleus membranes). Therefore, they show improved inhibition capacity cancer cells including drug resistant cell promote tumor suppression property vivo. We envision our constructing by metal chelation would offer new opportunities develop combination chemotherapy.

Language: Английский

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A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy

Nano-Micro Letters, Journal Year: 2020, Volume and Issue: 12(1)

Published: July 5, 2020

Abstract Although notable progress has been made on novel cancer treatments, the overall survival rate and therapeutic effects are still unsatisfactory for patients. Chemoimmunotherapy, combining chemotherapeutics immunotherapeutic drugs, emerged as a promising approach treatment, with advantages of cooperating two kinds treatment mechanism, reducing dosage drug enhancing effect. Moreover, nano-based delivery system (NDDS) was applied to encapsulate chemotherapeutic agents exhibited outstanding properties such targeted delivery, tumor microenvironment response site-specific release. Several nanocarriers have approved in clinical chemotherapy showed significant improvement efficiency compared traditional formulations, liposomes (Doxil ® , Lipusu ), nanoparticles (Abraxane ) micelles (Genexol-PM ). The applications NDDS chemoimmunotherapy would be powerful strategy future which could greatly enhance efficacy, reduce side optimize outcomes Herein, current approaches immunotherapy were discussed, recent advances further reviewed.

Language: Английский

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Supramolecular Photothermal Nanomaterials as an Emerging Paradigm toward Precision Cancer Therapy

Advanced Functional Materials, Journal Year: 2018, Volume and Issue: 29(4)

Published: Nov. 30, 2018

Abstract The concept of the “supramolecular photothermal effects” refers to collection property and conversion efficiency resulting from supramolecular assembly molecular sensitizers. This review considers organic materials assembled at nanoscale via various self‐assembly strategies associated with organization multiple noncovalent interactions. In these materials, individual photosensitizer molecules are typically aggregated through in a certain form that exhibits enhanced biostability, increased photoluminescence quenching, improved therapeutic effects comparison those monomeric molecules. These controlled or influenced by intermolecular interactions, especially hydrophobic effects, which distinct mechanisms conventional sensitizer polymers inorganic agents. A focus lies on how give rise including polymer protein fabrication, small molecule self‐assembly, construction donor–acceptor binary systems. Emphases placed rational design nanomaterials, drug delivery, vivo effects. Finally, key challenges promising prospects nanomaterials terms both technical advances clinical translation discussed.

Language: Английский

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