TH2 cell development and function DOI
Jennifer A. Walker, Andrew N. J. McKenzie

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 18(2), P. 121 - 133

Published: Oct. 30, 2017

Language: Английский

The microbiota in adaptive immune homeostasis and disease DOI
Kenya Honda, Dan R. Littman

Nature, Journal Year: 2016, Volume and Issue: 535(7610), P. 75 - 84

Published: July 5, 2016

Language: Английский

Citations

1605
Immunopathogenesis of IBD: current state of the art DOI
Heitor Siffert Pereira de Souza, Claudio Fiocchi

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2015, Volume and Issue: 13(1), P. 13 - 27

Published: Dec. 2, 2015

Language: Английский

Citations

1316
Homeostatic Immunity and the Microbiota DOI Creative Commons
Yasmine Belkaid, Oliver J. Harrison

Immunity, Journal Year: 2017, Volume and Issue: 46(4), P. 562 - 576

Published: April 1, 2017

Language: Английский

Citations

1030
Interleukin-33 in health and disease DOI

Foo Y. Liew,

Jean‐Philippe Girard,

Heth Roderick Turnquist

et al.

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(11), P. 676 - 689

Published: Sept. 19, 2016

Language: Английский

Citations

954
The far-reaching scope of neuroinflammation after traumatic brain injury DOI Open Access
Dennis Simon, Mandy J. McGeachy, Hülya Bayır

et al.

Nature Reviews Neurology, Journal Year: 2017, Volume and Issue: 13(3), P. 171 - 191

Published: Feb. 10, 2017

Language: Английский

Citations

888
A Distinct Function of Regulatory T Cells in Tissue Protection DOI Creative Commons
Nicholas Arpaia,

Jesse A. Green,

Bruno Moltedo

et al.

Cell, Journal Year: 2015, Volume and Issue: 162(5), P. 1078 - 1089

Published: Aug. 1, 2015

Language: Английский

Citations

865
Regulatory T Cells and Human Disease DOI
Shimon Sakaguchi, Norihisa Mikami, James B. Wing

et al.

Annual Review of Immunology, Journal Year: 2020, Volume and Issue: 38(1), P. 541 - 566

Published: Feb. 4, 2020

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the transcription factor FoxP3 in nucleus and CD25 CTLA-4 on cell surface, are a functionally distinct subpopulation actively engaged maintenance of immunological self-tolerance homeostasis. Recent studies have facilitated our understanding cellular molecular basis their generation, function, phenotypic functional stability, adaptability. It is under investigation humans how or numerical Treg anomalies, whether genetically determined environmentally induced, contribute to diseases such as autoimmune diseases. Also being addressed Tregs can be targeted control physiological pathological immune responses, for example, by depleting them enhance tumor immunity expanding treat This review discusses current immunobiology normal disease states, with perspective realization Treg-targeting therapies clinic.

Language: Английский

Citations

847
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity DOI Creative Commons
Alberto Mantovani, Charles A. Dinarello, Martina Molgora

et al.

Immunity, Journal Year: 2019, Volume and Issue: 50(4), P. 778 - 795

Published: April 1, 2019

Language: Английский

Citations

845
Individual intestinal symbionts induce a distinct population of RORγ + regulatory T cells DOI Open Access
Esen Sefik, Naama Geva‐Zatorsky, Sungwhan F. Oh

et al.

Science, Journal Year: 2015, Volume and Issue: 349(6251), P. 993 - 997

Published: Aug. 14, 2015

Gut microbes make T cells keep the peace Our guts harbor trillions of microbial inhabitants, some which regulate types immune that are present in gut. For instance, Clostridium species bacteria induce a type cell promotes tolerance between host and its contents. Ohnmacht et al. Sefik characterized population gut regulatory mice, required microbiota to survive. Multiple bacterial could transcription factor–expressing helped maintain homeostasis. Mice engineered lack these factors exhibited enhanced susceptibility colonic inflammation had elevated amounts proinflammatory molecules associated with allergies (see Perspective by Hegazy Powrie). Science , this issue pp. 989 993

Language: Английский

Citations

773
The microbiota regulates type 2 immunity through RORγt + T cells DOI Open Access
Caspar Ohnmacht,

Joo-Hong Park,

Sascha Cording

et al.

Science, Journal Year: 2015, Volume and Issue: 349(6251), P. 989 - 993

Published: July 10, 2015

Gut microbes make T cells keep the peace Our guts harbor trillions of microbial inhabitants, some which regulate types immune that are present in gut. For instance, Clostridium species bacteria induce a type cell promotes tolerance between host and its contents. Ohnmacht et al. Sefik characterized population gut regulatory mice, required microbiota to survive. Multiple bacterial could transcription factor–expressing helped maintain homeostasis. Mice engineered lack these factors exhibited enhanced susceptibility colonic inflammation had elevated amounts proinflammatory molecules associated with allergies (see Perspective by Hegazy Powrie). Science , this issue pp. 989 993

Language: Английский

Citations

754