Regulation of inflammation by microbiota interactions with the host

Nature Immunology, Journal Year: 2017, Volume and Issue: 18(8), P. 851 - 860

Published: July 19, 2017

Language: Английский

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Discriminating self from non-self in nucleic acid sensing

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(9), P. 566 - 580

Published: July 25, 2016

Language: Английский

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The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease

Frontiers in Microbiology, Journal Year: 2018, Volume and Issue: 9

Published: Sept. 25, 2018

In the twenty first century, changing epidemiology of inflammatory bowel disease (IBD) globally with increasing incidence across many countries relates to altered gut microbiota, due a combinatorial effect environmental factors, human immune responses and genetics. IBD is gastrointestinal associated dysbiosis, characterized by changes in microbial communities that include an expansion facultative anaerobic bacteria family Enterobacteriaceae. Advances high-throughput sequencing enable us entangle microbiota health beyond bacterial including mycobiota, virobiota helminthes. Caudovirales (viruses) Basidiomycota, Ascomycota C.albicans (fungi) are revealed be increased IBD. The deconvolution lays basis for unveiling roles these various components pathogenesis being conductive instructing on future diagnosis therapeutics. Here we comprehensively elucidate alterations IBD, discuss diets relation illustrate potential manipulation therapeutic strategy antibiotics, probiotics, prebiotics fecal transplantation will benefit effective application precision microbiome

Language: Английский

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The role of the gut microbiome in systemic inflammatory disease

BMJ, Journal Year: 2018, Volume and Issue: unknown, P. j5145 - j5145

Published: Jan. 8, 2018

ABSTRACT

The role of the gut microbiome in models inflammatory and autoimmune disease is now well characterized. Renewed interest human its metabolites, as notable advances host mucosal immunology, has opened multiple avenues research to potentially modulate responses. complexity interdependence these diet-microbe-metabolite-host interactions are rapidly being unraveled. Importantly, most progress field comes from new knowledge about functional properties microorganisms physiology their effect immunity distal inflammation. This review summarizes preclinical clinical evidence on how dietary, probiotic, prebiotic, based therapeutics affect our understanding wellness disease, particularly autoimmunity.

Language: Английский

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The gut microbiome in human neurological disease: A review

Annals of Neurology, Journal Year: 2017, Volume and Issue: 81(3), P. 369 - 382

Published: Feb. 21, 2017

Almost half the cells and 1% of unique genes found in our bodies are human, rest from microbes, predominantly bacteria, archaea, fungi, viruses. These microorganisms collectively form human microbiota, with most colonizing gut. Recent technological advances, open access data libraries, application high‐throughput sequencing have allowed these microbes to be identified their contribution neurological health examined. Emerging evidence links perturbations gut microbiota disease, including disease risk, activity, progression. This review provides an overview recent advances microbiome research relation neuro(auto)immune neurodegenerative conditions affecting humans, such as multiple sclerosis, neuromyelitis optica spectrum disorders, Parkinson Alzheimer Huntington amyotrophic lateral sclerosis. Study design terminology used this rapidly evolving, highly multidisciplinary field summarized empower engage neurology community “newly discovered organ.” Ann Neurol 2017;81:369–382

Language: Английский

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The microbial metabolite desaminotyrosine protects from influenza through type I interferon

Science, Journal Year: 2017, Volume and Issue: 357(6350), P. 498 - 502

Published: Aug. 3, 2017

The microbiota is known to modulate the host response influenza infection through as-yet-unclear mechanisms. We hypothesized that components of exert effects type I interferon (IFN), a hypothesis supported by analysis in gain-of-function genetic mouse model. Here we show microbially associated metabolite, desaminotyrosine (DAT), protects from augmentation IFN signaling and diminution lung immunopathology. A specific human-associated gut microbe, Clostridium orbiscindens, produced DAT rescued antibiotic-treated influenza-infected mice. protected priming amplification loop signaling. These findings enteric have distal on responses lethal infections modulation IFN.

Language: Английский

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Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria

Frontiers in Physiology, Journal Year: 2018, Volume and Issue: 9

Published: Oct. 31, 2018

As the intestinal microbiota has become better appreciated as necessary for maintenance of physiologic homeostasis and also a modulator disease processes, there been corresponding increase in manipulation mouse models. While germ-free models are generally considered to be gold standard studies microbiota, many investigators turn antibiotics treatment rapid, inexpensive accessible alternative. Here we describe compare these two approaches, detailing advantages disadvantages both. Further, detail what is known about effects on cell populations, cytokines, organs, clarify how this compares Finally, briefly recent findings regarding regulation infectious diseases other immunologic challenges by highlight important future directions considerations use microbiota.

Language: Английский

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Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis

Cell Host & Microbe, Journal Year: 2019, Volume and Issue: 25(2), P. 285 - 299.e8

Published: Feb. 1, 2019

Language: Английский

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The human virome: assembly, composition and host interactions

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 19(8), P. 514 - 527

Published: March 30, 2021

Language: Английский

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Fecal microbiota transplantation: Review and update

Journal of the Formosan Medical Association, Journal Year: 2018, Volume and Issue: 118, P. S23 - S31

Published: Sept. 1, 2018

Fecal microbiota transplantation (FMT) is a method to directly change the recipient's gut normalize composition and gain therapeutic benefit. The history of FMT has been traced back 4th century highly regarded since 2013, when United States Food Drug Administration approved for treating recurrent refractory Clostridium difficile infection. Since then, range applications extended rapidly broadly not only in gastrointestinal disorders, but also extra-gastrointestinal diseases. Donor selection with questionnaire, interview, blood tests, stool examinations should be strictly performed before reduce prevent occurrence any adverse events. Step-by-step cautious fecal recipient preparation along adequately choosing delivery methods based on individual clinical situations are key points process. Although current evidence deems as generally safe few effects, long-term outcomes have completely elucidated. Therefore, establishing periodicity length regular follow-up after monitor efficacy events other essential issues. In future, we will look forward personalized different patients conditions according varied hosts

Language: Английский

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