Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Nature, Journal Year: 2017, Volume and Issue: 547(7664), P. 453 - 457

Published: July 1, 2017

Language: Английский

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Single-cell RNA sequencing technologies and bioinformatics pipelines

Experimental & Molecular Medicine, Journal Year: 2018, Volume and Issue: 50(8), P. 1 - 14

Published: Aug. 1, 2018

Rapid progress in the development of next-generation sequencing (NGS) technologies recent years has provided many valuable insights into complex biological systems, ranging from cancer genomics to diverse microbial communities. NGS-based for genomics, transcriptomics, and epigenomics are now increasingly focused on characterization individual cells. These single-cell analyses will allow researchers uncover new potentially unexpected discoveries relative traditional profiling methods that assess bulk populations. Single-cell RNA (scRNA-seq), example, can reveal rare cell populations, regulatory relationships between genes, track trajectories distinct lineages development. In this review, we focus technical challenges isolation library preparation computational analysis pipelines available analyzing scRNA-seq data. Further improvements at level molecular biology bioinformatics tools greatly facilitate both basic science medical applications these technologies. Showing which genes expressed, or switched on, cells may help first signs disease. Each an organism contains same genetic information, but type behavior depend expressed. Previously, could only sequence batches, averaging results, technological expressed cell, known as (scRNA-seq). Ji Hyun Lee (Kyung Hee University, Seoul) Duhee Bang Byungjin Hwang (Yonsei have reviewed strategies analyze large quantities data produced. They conclude impact science, illuminating drug resistance revealing pathways differentiation during

Language: Английский

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Nature, Journal Year: 2017, Volume and Issue: 551(7679), P. 247 - 250

Published: Oct. 31, 2017

Language: Английский

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YAP/TAZ upstream signals and downstream responses

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(8), P. 888 - 899

Published: July 19, 2018

Language: Английский

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Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

Cancer Cell, Journal Year: 2018, Volume and Issue: 33(5), P. 890 - 904.e5

Published: April 12, 2018

Language: Английский

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Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance

Cancer Cell, Journal Year: 2020, Volume and Issue: 37(4), P. 471 - 484

Published: April 1, 2020

Language: Английский

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SAVER: gene expression recovery for single-cell RNA sequencing

Nature Methods, Journal Year: 2018, Volume and Issue: 15(7), P. 539 - 542

Published: June 22, 2018

Language: Английский

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Toward Minimal Residual Disease-Directed Therapy in Melanoma

Cell, Journal Year: 2018, Volume and Issue: 174(4), P. 843 - 855.e19

Published: July 13, 2018

Language: Английский

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Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(3), P. 1102 - 1102

Published: Feb. 7, 2020

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction that regulate all aspects of life and are frequently altered in disease. Here, we focus on the role MAPK modulating drug sensitivity resistance cancer. We briefly discuss new findings extracellular signaling-regulated (ERK) pathway, but mainly mechanisms how stress activated pathways, such as p38 Jun N-terminal kinases (JNK), impact response cancer cells to chemotherapies targeted therapies. In this context, also metabolic epigenetic aberrations therapeutic opportunities arising from these changes.

Language: Английский

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The great escape: tumour cell plasticity in resistance to targeted therapy

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: 19(1), P. 39 - 56

Published: Oct. 10, 2019

Language: Английский

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