Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Cell Death and Differentiation, Journal Year: 2018, Volume and Issue: 25(3), P. 486 - 541

Published: Jan. 23, 2018

Over the past decade, Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for definition and interpretation of cell death from morphological, biochemical, functional perspectives. Since field continues to expand novel mechanisms that orchestrate multiple pathways are unveiled, we propose an updated classification subroutines focusing mechanistic essential (as opposed correlative dispensable) aspects process. As provide molecularly oriented definitions terms including intrinsic apoptosis, extrinsic mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic death, NETotic lysosome-dependent autophagy-dependent immunogenic cellular senescence, mitotic catastrophe, discuss utility neologisms refer highly specialized instances these processes. The mission NCCD is a widely accepted nomenclature in support continued development field.

Language: Английский

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Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: 18(3), P. 197 - 218

Published: Jan. 4, 2019

Language: Английский

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The cGAS–STING pathway as a therapeutic target in inflammatory diseases

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(9), P. 548 - 569

Published: April 8, 2021

Language: Английский

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Molecular mechanisms and cellular functions of cGAS–STING signalling

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(9), P. 501 - 521

Published: May 18, 2020

Language: Английский

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DAMP-sensing receptors in sterile inflammation and inflammatory diseases

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 20(2), P. 95 - 112

Published: Sept. 26, 2019

Language: Английский

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Chromosomal instability drives metastasis through a cytosolic DNA response

Nature, Journal Year: 2018, Volume and Issue: 553(7689), P. 467 - 472

Published: Jan. 17, 2018

Language: Английский

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DNA sensing by the cGAS–STING pathway in health and disease

Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 20(11), P. 657 - 674

Published: July 29, 2019

Language: Английский

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The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 215(5), P. 1287 - 1299

Published: April 5, 2018

Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host immune system to mount a defense response infections. However, this detection also poses challenge as how distinguish foreign from abundant self-DNA. Cyclic guanosine monophosphate (GMP)-adenosine (AMP) synthase (cGAS) sensor triggers innate responses through production second messenger cyclic GMP-AMP (cGAMP), which binds and activates adaptor protein STING. cGAS can be activated by double-stranded irrespective sequence, including Although normally kept inactive in cells still not well understood, recent research has provided strong evidence genomic damage leads activation stimulate inflammatory responses. This review summarizes findings on instability trigger serves link inflammation, cellular senescence, cancer.

Language: Английский

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The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

Cancer Discovery, Journal Year: 2019, Volume and Issue: 10(1), P. 26 - 39

Published: Dec. 18, 2019

The recognition of DNA as an immune-stimulatory molecule is evolutionarily conserved mechanism to initiate rapid innate immune responses against microbial pathogens. cGAS-STING pathway was discovered important DNA-sensing machinery in immunity and viral defense. Recent advances have now expanded the roles cancer. Highly aggressive, unstable tumors evolved co-opt this program drive tumorigenic behaviors. In review, we discuss link between antitumor well cancer progression, genomic instability, tumor microenvironment, pharmacologic strategies for therapy. SIGNIFICANCE: defense infections. Given its role activating surveillance, it has been assumed that primarily functions a suppressor. Yet, mounting evidence suggests depending on context, signaling can also metastasis-promoting functions, chronic activation paradoxically induce immune-suppressive microenvironment.

Language: Английский

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Immunogenic cell stress and death

Nature Immunology, Journal Year: 2022, Volume and Issue: 23(4), P. 487 - 500

Published: Feb. 10, 2022

Language: Английский

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