Innate Lymphoid Cells: 10 Years On

Cell, Journal Year: 2018, Volume and Issue: 174(5), P. 1054 - 1066

Published: Aug. 1, 2018

Language: Английский

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The Cytokines of Asthma

Immunity, Journal Year: 2019, Volume and Issue: 50(4), P. 975 - 991

Published: April 1, 2019

Language: Английский

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Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

Nature Biotechnology, Journal Year: 2020, Volume and Issue: 38(6), P. 737 - 746

Published: April 6, 2020

Language: Английский

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The basic immunology of asthma

Cell, Journal Year: 2021, Volume and Issue: 184(6), P. 1469 - 1485

Published: March 1, 2021

Language: Английский

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The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Cell, Journal Year: 2020, Volume and Issue: 181(2), P. 236 - 249

Published: April 1, 2020

Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic ecosystem. Transformative single-cell genomics technologies spatial multiplex situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of National Cancer Institute (NCI) Moonshot Initiative, will establish a clinical, experimental, computational, organizational framework generate informative accessible three-dimensional atlases cancer for diverse set types. This effort complements both ongoing efforts map healthy organs previous large-scale approaches focused on bulk sequencing single point time. Generating single-cell, multiparametric, longitudinal integrating them with clinical outcomes should help identify novel predictive biomarkers features as well therapeutically relevant cell types, states, cellular across transitions. resulting have profound impact our understanding biology potential improve detection, prevention, discovery better precision-medicine treatments patients those risk cancer.

Language: Английский

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The Human and Mouse Enteric Nervous System at Single-Cell Resolution

Cell, Journal Year: 2020, Volume and Issue: 182(6), P. 1606 - 1622.e23

Published: Sept. 1, 2020

Language: Английский

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Molecular and Functional Neuroscience in Immunity

Annual Review of Immunology, Journal Year: 2018, Volume and Issue: 36(1), P. 783 - 812

Published: April 20, 2018

The nervous system regulates immunity and inflammation. molecular detection of pathogen fragments, cytokines, other immune molecules by sensory neurons generates immunoregulatory responses through efferent autonomic neuron signaling. functional organization this neural control is based on principles reflex regulation. Reflexes involving the vagus nerve nerves have been therapeutically explored in models inflammatory autoimmune conditions, recently clinical settings. brain integrates neuro-immune communication, function altered diseases characterized peripheral dysregulation Here we review anatomical basis interface with immunity, focusing functions role model immunological homunculus. Clinical advances stemming from knowledge within framework bioelectronic medicine are also briefly outlined.

Language: Английский

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Pain and immunity: implications for host defence

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(7), P. 433 - 447

Published: March 15, 2019

Language: Английский

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The Meningeal Lymphatic System: A New Player in Neurophysiology

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 375 - 388

Published: Oct. 1, 2018

Language: Английский

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Regulation of immune responses by the airway epithelial cell landscape

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(6), P. 347 - 362

Published: Jan. 13, 2021

Language: Английский

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