Open Biology, Journal Year: 2018, Volume and Issue: 8(9)

Published: Sept. 1, 2018

Synaptic dysfunction in CNS disorders is the outcome of perturbations physiological synapse structure and function, can be either cause or consequence specific pathologies. Accumulating data field neuropsychiatric disorders, including autism spectrum schizophrenia bipolar disorder, point to a neurodevelopmental origin these Due relatively early onset behavioural cognitive symptoms, it generally acknowledged that mental illness initiates at level. On other hand, synaptic has been considered as an endpoint incident neurodegenerative diseases, such Alzheimer's, Parkinson's Huntington's, mainly due considerably later clinical symptoms progressive appearance deficits. This dichotomy recently challenged, particularly since discovery cell reprogramming technologies generation induced pluripotent stem cells from patient somatic cells. The creation ‘disease-in-a-dish’ models for multiple pathologies revealed unexpected commonalities molecular cellular mechanisms operating both developmental degenerative conditions, most which meet In this review we discuss prototype emphasizing overlapping features synaptopathy have suggested by studies using stem-cell-based systems. These valuable disease highlighted potential component classical diseases worth pursuing investigating further. Moving demonstration correlation understanding mechanistic causality forms basis developing novel therapeutics.

Language: Английский