CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

Nature Protocols, Journal Year: 2020, Volume and Issue: 15(4), P. 1484 - 1506

Published: Feb. 26, 2020

Language: Английский

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Fibrosis: from mechanisms to medicines

Nature, Journal Year: 2020, Volume and Issue: 587(7835), P. 555 - 566

Published: Nov. 25, 2020

Language: Английский

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Exploring tissue architecture using spatial transcriptomics

Nature, Journal Year: 2021, Volume and Issue: 596(7871), P. 211 - 220

Published: Aug. 11, 2021

Language: Английский

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A human liver cell atlas reveals heterogeneity and epithelial progenitors

Nature, Journal Year: 2019, Volume and Issue: 572(7768), P. 199 - 204

Published: July 10, 2019

Language: Английский

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Deciphering cell–cell interactions and communication from gene expression

Nature Reviews Genetics, Journal Year: 2020, Volume and Issue: 22(2), P. 71 - 88

Published: Nov. 9, 2020

Language: Английский

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Robust decomposition of cell type mixtures in spatial transcriptomics

Nature Biotechnology, Journal Year: 2021, Volume and Issue: 40(4), P. 517 - 526

Published: Feb. 18, 2021

Language: Английский

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Museum of spatial transcriptomics

Nature Methods, Journal Year: 2022, Volume and Issue: 19(5), P. 534 - 546

Published: March 10, 2022

Language: Английский

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Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

Molecular Cell, Journal Year: 2019, Volume and Issue: 75(3), P. 644 - 660.e5

Published: Aug. 1, 2019

Language: Английский

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Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

Immunity, Journal Year: 2019, Volume and Issue: 51(4), P. 638 - 654.e9

Published: Sept. 24, 2019

Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint tissue-specific identities macrophages in respective niches. Using conditional depletion liver Kupffer cells, we traced developmental stages monocytes differentiating into cells and mapped cellular imprinting cell identity. loss induced tumor necrosis factor (TNF)- interleukin-1 (IL-1) receptor-dependent activation stellate endothelial resulting transient production chemokines adhesion molecules orchestrating monocyte engraftment. Engrafted circulating transmigrated perisinusoidal space acquired liver-associated transcription factors inhibitor DNA 3 (ID3) X receptor-α (LXR-α). Coordinated with hepatocytes ID3 expression, whereas LXR-α via a synergistic NOTCH-BMP pathway. This study shows niche composed hepatocytes, together liver-specific macrophage

Language: Английский

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Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

Immunity, Journal Year: 2020, Volume and Issue: 53(3), P. 641 - 657.e14

Published: Sept. 1, 2020

Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, specifically Kupffer cells (KCs), are suggested play important roles in the pathogenesis MAFLD through their activation, although exact played by these remain unclear. Here, we demonstrated that KCs were reduced being replaced macrophages originating bone marrow. Recruited existed two subsets with distinct activation states, either closely resembling homeostatic or lipid-associated (LAMs) obese adipose tissue. LAMs expressed Osteopontin, biomarker for patients NASH, linked development fibrosis. Fitting this, found regions numbers KCs, characterized increased Desmin expression. Together, our data highlight considerable heterogeneity within macrophage pool and suggest need more specific targeting strategies MAFLD.

Language: Английский

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