Integrins as biomechanical sensors of the microenvironment

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(8), P. 457 - 473

Published: June 10, 2019

Language: Английский

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Atomic force microscopy-based mechanobiology

Nature Reviews Physics, Journal Year: 2018, Volume and Issue: 1(1), P. 41 - 57

Published: Oct. 31, 2018

Language: Английский

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Regulation of genome organization and gene expression by nuclear mechanotransduction

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(12), P. 717 - 727

Published: Oct. 18, 2017

Language: Английский

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The extracellular matrix in development

Development, Journal Year: 2020, Volume and Issue: 147(10)

Published: May 15, 2020

ABSTRACT As the crucial non-cellular component of tissues, extracellular matrix (ECM) provides both physical support and signaling regulation to cells. Some ECM molecules provide a fibrillar environment around cells, while others sheet-like basement membrane scaffold beneath epithelial In this Review, we focus on recent studies investigating mechanical, biophysical cues provided developing tissues by different types in variety organisms. addition, discuss how helps regulate tissue morphology during embryonic development governing key elements cell shape, adhesion, migration differentiation.

Language: Английский

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Control of Mechanotransduction by Molecular Clutch Dynamics

Trends in Cell Biology, Journal Year: 2018, Volume and Issue: 28(5), P. 356 - 367

Published: Feb. 26, 2018

Language: Английский

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Rethinking organoid technology through bioengineering

Nature Materials, Journal Year: 2020, Volume and Issue: 20(2), P. 145 - 155

Published: Nov. 16, 2020

Language: Английский

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Steps in Mechanotransduction Pathways that Control Cell Morphology

Annual Review of Physiology, Journal Year: 2018, Volume and Issue: 81(1), P. 585 - 605

Published: Nov. 7, 2018

It is increasingly clear that mechanotransduction pathways play important roles in regulating fundamental cellular functions. Of the basic mechanical functions, determination of morphology critical. Cells typically use many mechanosensitive steps and different cell states to achieve a polarized shape through repeated testing microenvironment. Indeed, determined by microenvironment periodic activation motility, mechanotesting, mechanoresponse functions hormones, internal clocks, receptor tyrosine kinases. Patterned substrates controlled environments with defined rigidities limit range behavior influence state decisions are thus very useful for studying these steps. The recently rigidity sensing process provides good example how cells repeatedly test their also linked cancer. In general, aberrant extracellular matrix mechanosensing associated numerous conditions, including cardiovascular disease, aging, fibrosis, correlate changes tissue composition. Hence, detailed descriptions involved responding needed better understand both mechanisms homeostasis pathomechanisms human disease.

Language: Английский

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Mechanoresponsive metabolism in cancer cell migration and metastasis

Cell Metabolism, Journal Year: 2021, Volume and Issue: 33(7), P. 1307 - 1321

Published: April 28, 2021

Language: Английский

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Receptor-mediated cell mechanosensing

Molecular Biology of the Cell, Journal Year: 2017, Volume and Issue: 28(23), P. 3134 - 3155

Published: Sept. 28, 2017

Mechanosensing describes the ability of a cell to sense mechanical cues its microenvironment, including not only all components force, stress, and strain but also substrate rigidity, topology, adhesiveness. This is crucial for respond surrounding adapt changing environment. Examples responses adaptation include (de)activation, proliferation/apoptosis, (de)differentiation. Receptor-mediated mechanosensing multistep process that initiated by binding surface receptors their ligands on extracellular matrix or adjacent cells. Mechanical are presented ligand received receptor at interface; transmission over space time conversion into biochemical signals may involve other domains additional molecules. In this review, four-step model described receptor-mediated process. Platelet glycoprotein Ib, T-cell receptor, integrins used as examples illustrate key concepts players in

Language: Английский

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Mechanical Force-Driven Adherens Junction Remodeling and Epithelial Dynamics

Developmental Cell, Journal Year: 2018, Volume and Issue: 47(1), P. 3 - 19

Published: Oct. 1, 2018

Language: Английский

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