Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 7, 2024
Multicellular
organisms
are
composed
of
diverse
cell
types
that
must
coordinate
their
behaviors
through
communication.
Cell-cell
communication
(CCC)
is
essential
for
growth,
development,
differentiation,
tissue
and
organ
formation,
maintenance,
physiological
regulation.
Cells
communicate
direct
contact
or
at
a
distance
using
ligand-receptor
interactions.
So
cellular
encompasses
two
processes:
signal
conduction
generation
intercellular
transmission
signals,
transduction
reception
procession
signals.
Deciphering
networks
critical
understanding
metabolism.
First,
we
comprehensively
review
the
historical
milestones
in
CCC
studies,
followed
by
detailed
description
mechanisms
molecule
importance
main
signaling
pathways
they
mediate
maintaining
biological
functions.
Then
systematically
introduce
series
human
diseases
caused
abnormalities
progress
clinical
applications.
Finally,
summarize
various
methods
monitoring
interactions,
including
imaging,
proximity-based
chemical
labeling,
mechanical
force
analysis,
downstream
analysis
strategies,
single-cell
technologies.
These
aim
to
illustrate
how
functions
depend
on
these
interactions
complexity
regulatory
regulate
crucial
processes,
homeostasis,
immune
responses
diseases.
In
addition,
this
enhances
our
processes
occur
after
cell-cell
binding,
highlighting
its
application
discovering
new
therapeutic
targets
biomarkers
related
precision
medicine.
This
collective
provides
foundation
developing
targeted
drugs
personalized
treatments.
Development,
Journal Year:
2020,
Volume and Issue:
147(10)
Published: May 15, 2020
ABSTRACT
As
the
crucial
non-cellular
component
of
tissues,
extracellular
matrix
(ECM)
provides
both
physical
support
and
signaling
regulation
to
cells.
Some
ECM
molecules
provide
a
fibrillar
environment
around
cells,
while
others
sheet-like
basement
membrane
scaffold
beneath
epithelial
In
this
Review,
we
focus
on
recent
studies
investigating
mechanical,
biophysical
cues
provided
developing
tissues
by
different
types
in
variety
organisms.
addition,
discuss
how
helps
regulate
tissue
morphology
during
embryonic
development
governing
key
elements
cell
shape,
adhesion,
migration
differentiation.
Annual Review of Physiology,
Journal Year:
2018,
Volume and Issue:
81(1), P. 585 - 605
Published: Nov. 7, 2018
It
is
increasingly
clear
that
mechanotransduction
pathways
play
important
roles
in
regulating
fundamental
cellular
functions.
Of
the
basic
mechanical
functions,
determination
of
morphology
critical.
Cells
typically
use
many
mechanosensitive
steps
and
different
cell
states
to
achieve
a
polarized
shape
through
repeated
testing
microenvironment.
Indeed,
determined
by
microenvironment
periodic
activation
motility,
mechanotesting,
mechanoresponse
functions
hormones,
internal
clocks,
receptor
tyrosine
kinases.
Patterned
substrates
controlled
environments
with
defined
rigidities
limit
range
behavior
influence
state
decisions
are
thus
very
useful
for
studying
these
steps.
The
recently
rigidity
sensing
process
provides
good
example
how
cells
repeatedly
test
their
also
linked
cancer.
In
general,
aberrant
extracellular
matrix
mechanosensing
associated
numerous
conditions,
including
cardiovascular
disease,
aging,
fibrosis,
correlate
changes
tissue
composition.
Hence,
detailed
descriptions
involved
responding
needed
better
understand
both
mechanisms
homeostasis
pathomechanisms
human
disease.
Molecular Biology of the Cell,
Journal Year:
2017,
Volume and Issue:
28(23), P. 3134 - 3155
Published: Sept. 28, 2017
Mechanosensing
describes
the
ability
of
a
cell
to
sense
mechanical
cues
its
microenvironment,
including
not
only
all
components
force,
stress,
and
strain
but
also
substrate
rigidity,
topology,
adhesiveness.
This
is
crucial
for
respond
surrounding
adapt
changing
environment.
Examples
responses
adaptation
include
(de)activation,
proliferation/apoptosis,
(de)differentiation.
Receptor-mediated
mechanosensing
multistep
process
that
initiated
by
binding
surface
receptors
their
ligands
on
extracellular
matrix
or
adjacent
cells.
Mechanical
are
presented
ligand
received
receptor
at
interface;
transmission
over
space
time
conversion
into
biochemical
signals
may
involve
other
domains
additional
molecules.
In
this
review,
four-step
model
described
receptor-mediated
process.
Platelet
glycoprotein
Ib,
T-cell
receptor,
integrins
used
as
examples
illustrate
key
concepts
players
in
