Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582

Published: Feb. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Language: Английский

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Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)

Published: Aug. 6, 2023

Hydrogels with tailor-made swelling-shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients metabolites, well drug diffusion release, hydrogels high capacity been widely applicated full-thickness skin healing tissue regeneration, delivery. Nevertheless, fields adhesives internal soft-tissue healing, bioelectronics, non-swelling play very important functions owing to their stable macroscopic dimension physical performance physiological environment. Moreover, negative behavior (i.e., shrinkage) can be exploited drive noninvasive closure, achieve resolution enhancement hydrogel scaffolds. In addition, it help push out entrapped drugs, thus promote release. However, there still has not general review constructions applications from viewpoint properties. Therefore, this summarizes tactics employed so far tailoring applications. And relatively comprehensive understanding current progress future challenge different features provided potential clinical translations.

Language: Английский

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All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: March 2, 2023

Abstract Macrophages are highly heterogeneous and exhibit a diversity of functions phenotypes. They can be divided into pro‐inflammatory macrophages (M1) anti‐inflammatory (M2). Diabetic wounds characterized by prolonged inflammatory phase difficulty in healing due to the accumulation wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise promoting diabetic wound clinical applications. However, precise conversion M1 M2 simple biosafe approaches is still challenge. Here, an all‐natural ability regulate developed promote angiogenesis healing. The protocatechuic aldehyde hybridized collagen‐based exhibits good bioadhesive antibacterial properties as well reactive oxygen species scavenging ability. More importantly, able convert without need for any additional ingredients or external intervention. This safe immunomodulatory approach shows application potential shortening repair accelerating

Language: Английский

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High-strength hydrogels: Fabrication, reinforcement mechanisms, and applications

Nano Research, Journal Year: 2023, Volume and Issue: 16(2), P. 3475 - 3515

Published: Jan. 3, 2023

Language: Английский

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3D-printed PEDOT:PSS for soft robotics

Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(9), P. 604 - 622

Published: Aug. 24, 2023

Language: Английский

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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Language: Английский

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Photoinduced Dithiolane Crosslinking for Multiresponsive Dynamic Hydrogels

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 30, 2023

While many hydrogels are elastic networks crosslinked by covalent bonds, viscoelastic with adaptable crosslinks increasingly being developed to better recapitulate time and position-dependent processes found in tissues. In this work, 1,2-dithiolanes presented as dynamic photocrosslinkers of hydrogels, resulting disulfide bonds throughout the hydrogel that respond multiple stimuli. Using lipoic acid a model dithiolane, formed under physiological conditions, enabling cell encapsulation via an initiator-free light-induced dithiolane ring-opening photopolymerization. The allow for photoinduced responses including stress relaxation, stiffening, softening, network functionalization using single chemistry, which can be supplemented permanent reaction alkenes further control properties connectivity irreversible thioether crosslinks. Moreover, complementary photochemical approaches used achieve rapid complete sample degradation radical scission post-gelation stiffening when irradiated presence reactive gel precursor. results herein demonstrate versatility material chemistry study direct 2D 3D cell-material interactions. This work highlights dithiolane-based photocrosslinking robust method generating range biologically relevant mechanical chemical varied on demand.

Language: Английский

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Recent advances in defined hydrogels in organoid research

Bioactive Materials, Journal Year: 2023, Volume and Issue: 28, P. 386 - 401

Published: June 16, 2023

Organoids are in vitro model systems that mimic the complexity of organs with multicellular structures and functions, which provide great potential for biomedical tissue engineering. However, their current formation heavily relies on using complex animal-derived extracellular matrices (ECM), such as Matrigel. These often poorly defined chemical components exhibit limited tunability reproducibility. Recently, biochemical biophysical properties hydrogels can be precisely tuned, offering broader opportunities to support development maturation organoids. In this review, fundamental ECM vivo critical strategies design organoid culture summarized. Two typically derived from natural synthetic polymers applicability improve organoids presented. The representative applications incorporating into highlighted. Finally, some challenges future perspectives also discussed developing advanced technologies toward supporting research.

Language: Английский

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3D Printing of Self‐Assembling Nanofibrous Multidomain Peptide Hydrogels

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(11)

Published: Jan. 6, 2023

3D printing has become one of the primary fabrication strategies used in biomedical research. Recent efforts have focused on hydrogels to create structures that better replicate mechanical properties biological tissues. These pose a unique challenge, as soft materials are difficult pattern three dimensions with high fidelity. Currently, small number biologically derived polymers form frequently reused for applications. Thus, there exists need novel desirable can be printable inks. In this work, printability multidomain peptides (MDPs), class self-assembling nanofibrous hydrogel at low concentrations, is established. MDPs different charge functionalities optimized distinct inks and complex structures, including multi-MDP prints. Additionally, printed MDP constructs demonstrate charge-dependent differences cellular behavior vitro. This work presents first time been print layered overhangs internal porosity. Overall, promising new uniquely peptide-based rely solely supramolecular mechanisms assembly.

Language: Английский

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Stimuli‐Responsive Hydrogels for Antibacterial Applications

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 9, 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.

Language: Английский

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