Bacterial siderophores in community and host interactions

Nature Reviews Microbiology, Journal Year: 2019, Volume and Issue: 18(3), P. 152 - 163

Published: Nov. 20, 2019

Language: Английский

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The Natural Biotic Environment ofCaenorhabditis elegans

Genetics, Journal Year: 2017, Volume and Issue: 206(1), P. 55 - 86

Published: May 1, 2017

Abstract Organisms evolve in response to their natural environment. Consideration of ecological parameters are thus key importance for our understanding an organism’s biology. Curiously, the ecology model species Caenorhabditis elegans has long been neglected, even though this nematode become one most intensively studied models biological research. This lack interest changed ∼10 yr ago. Since then, increasing number studies have focused on nematode’s ecology. Yet many unknowns still remain. Here, we provide overview currently available information environment C. elegans. We focus biotic environment, which is usually less predictable and can create high selective constraints that likely had a strong impact evolution. particularly abundant microbe-rich environments, especially rotting plant matter such as decomposing fruits stems. In it part complex interaction network, shaped by species-rich microbial community. These microbes be food, beneficial gut microbiome, parasites pathogens, possibly competitors. additionally confronted with predators; interacts vector organisms facilitate dispersal new habitats, also competitors similar food including from congeneric same species. Full appreciation biology warrants further exploration its subsequent integration into well-established laboratory-based research approaches.

Language: Английский

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The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 627, P. 1018 - 1038

Published: Feb. 3, 2018

Plants, animals and humans, are colonized by microorganisms (microbiota) transiently exposed to countless others. The microbiota affects the development function of essentially all organ systems, contributes adaptation evolution, while protecting against pathogenic toxins. Genetics lifestyle factors, including diet, antibiotics other drugs, exposure natural environment, affect composition microbiota, which influences host health through modulation interrelated physiological systems. These include immune system regulation, metabolic endocrine pathways, brain epigenetic modification genome. Importantly, parental microbiotas have transgenerational impacts on progeny. Humans, plants share similar relationships with microbes. Research paradigms from humans mammals, amphibians, insects, planktonic crustaceans demonstrate influence environmental microbial ecosystems organisms, indicate links between internal diversity good health. Therefore, overlapping compositions, interconnected roles microbes in human, animal plant should be considered within broader context terrestrial aquatic that challenged human agricultural industrial activities. Here, we propose research priorities organizational, educational administrative measures will help identify safe microbe-associated health-promoting modalities practices. In spirit an expanding version "One health" includes its relation cultures habits (EcoHealth), urge lifestyle-microbiota-human nexus taken into account societal decision making.

Language: Английский

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Caenorhabditis elegans as a Model for Microbiome Research

Frontiers in Microbiology, Journal Year: 2017, Volume and Issue: 8

Published: March 23, 2017

The nematode Caenorhabditis elegans is used as a central model system across biological disciplines. Surprisingly, almost all research with this worm performed in the absence of its native microbiome, possibly affecting generality obtained results. In fact, C. microbiome had been unknown until recently. This review brings together results from first three studies on microbiomes, published 2016. Meta-analysis data demonstrates considerable conservation composition microbial communities, despite distinct geographical sample origins, study approaches, labs involved and perturbations during processing. enriched some cases selective for phylotypes compared to corresponding substrate samples (e.g., rotting fruits, decomposing plant matter, compost soil). dominant bacterial groups include several Gammaproteobacteria (Enterobacteriaceae, Pseudomonaceae, Xanthomonodaceae) Bacteroidetes (Sphingobacteriaceae, Weeksellaceae, Flavobacteriaceae). They are consistently joined by rare putative keystone taxa like Acetobacteriaceae. bacteria able enhance growth populations, well resistance biotic abiotic stressors, including high/low temperatures, osmotic stress, pathogenic fungi. associated microbes thus appear display variety effects beneficial worm. characteristics these effects, their relevance fitness, presence specific co-adaptations between members worm, molecular underpinnings microbiome-host interactions represent promising areas future research, which advantages an experimental should prove particular value.

Language: Английский

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Microbial evolution and transitions along the parasite–mutualist continuum

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 19(10), P. 623 - 638

Published: April 19, 2021

Virtually all plants and animals, including humans, are home to symbiotic microorganisms. Symbiotic interactions can be neutral, harmful or have beneficial effects on the host organism. However, growing evidence suggests that microbial symbionts evolve rapidly, resulting in drastic transitions along parasite–mutualist continuum. In this Review, we integrate theoretical empirical findings discuss mechanisms underpinning these evolutionary shifts, as well ecological drivers why some host–microorganism may stuck at end of addition having biomedical consequences, understanding dynamic life microorganisms reveals how symbioses shape an organism's biology entire community, particularly a changing world. for organisms. Drew, Stevens King continuum, underlying changes, selective pressures involved common approaches studying them.

Language: Английский

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Host microbiota can facilitate pathogen infection

PLoS Pathogens, Journal Year: 2021, Volume and Issue: 17(5), P. e1009514 - e1009514

Published: May 13, 2021

Animals live in symbiosis with numerous microbe species. While some can protect hosts from infection and benefit host health, components of the microbiota or changes to microbial landscape have potential facilitate infections worsen disease severity. Pathogens pathobionts exploit metabolites, take advantage a depletion defences changing conditions within host, cause opportunistic infection. The might also favour more virulent evolutionary trajectory for invading pathogens. In this review, we consider ways which contributes infectious throughout host’s life potentially across time. We further discuss implications these negative outcomes manipulation engineering management.

Language: Английский

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Toxic effects of nanoplastics on biological nitrogen removal in constructed wetlands: Evidence from iron utilization and metabolism

Water Research, Journal Year: 2024, Volume and Issue: 256, P. 121577 - 121577

Published: April 6, 2024

Language: Английский

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The role of animal hosts in shaping gut microbiome variation

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1901)

Published: March 18, 2024

Millions of years co-evolution between animals and their associated microbial communities have shaped diversified the nature relationship. Studies continue to reveal new layers complexity in host–microbe interactions, fate which depends on a variety different factors, ranging from neutral processes environmental factors local dynamics. Research is increasingly integrating ecosystem-based approaches, metagenomics mathematical modelling disentangle individual contribution ecological microbiome evolution. Within this framework, host are known be among dominant drivers composition animal species. However, extent they shape assembly evolution remains unclear. In review, we summarize our understanding how drive these dynamics conserved vary across taxa. We conclude by outlining key avenues for research highlight need implementation modifications existing theory fully capture host-associated microbiomes. This article part theme issue ‘Sculpting microbiome: determine respond colonization’.

Language: Английский

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Syzygium malaccense leaf extract-mediated silver nanoparticles: synthesis, characterization, and biomedical evaluation in Caenorhabditis elegans and lung cancer cell line

Green Chemistry Letters and Reviews, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 30, 2025

The study explores the green synthesis and characterization of silver nanoparticles using Syzygium malaccense (L.) Merr. & L. M. Perry leaf extract (SM-AgNPs). UV-Visible spectroscopy confirmed reduction ions, showing an absorption peak at 406 nm. X-ray Diffraction (XRD) analysis revealed a face centered cubic structure with average particle size 23.55 Dynamic Light Scattering (DLS) zeta potential analyses indicated mean 40.1 nm surface charge −40.1 mV. FTIR identified functional groups involved in nanoparticle stabilization, while Energy Dispersive (EDX) content. Transmission Electron Microscopy (TEM) Atomic Force (AFM) provided detailed insights into morphology. Anticancer assays showed dose-dependent cytotoxicity against A549 cancer cells (LC50: 7.62 μg mL−1) minimal effects on L-132 normal 73.55 mL−1), highlighting selectivity. Additionally, SM-AgNPs increased Caenorhabditis elegans survival reduced paralysis under pathogenic bacterial exposure. This demonstrates biomedical applications, emphasizing selective anticancer activity antimicrobial vivo.

Language: Английский

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Survival assays using Caenorhabditis elegans

Molecules and Cells, Journal Year: 2017, Volume and Issue: 40(2), P. 90 - 99

Published: Feb. 1, 2017

Caenorhabditis elegans is an important model organism with many useful features, including rapid development and aging, easy cultivation, genetic tractability.Survival assays using C. are powerful methods for studying physiological processes.In this review, we describe diverse types of survival discuss the aims, uses, ad- vantages specific assays.C. have played key roles in identifying novel factors that regulate aspects animal physiology, such as aging lifespan, stress response, immunity against pathogens.Because discovered evolutionarily conserved, can provide insights into mechanisms underlying processes mammals, humans.

Language: Английский

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