Spontaneous Spiking Is Governed by Broadband Fluctuations

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(26), P. 5159 - 5172

Published: May 23, 2022

Populations of cortical neurons generate rhythmic fluctuations in their ongoing spontaneous activity. These can be seen the local field potential (LFP), which reflects summed return currents from synaptic activity population near a recording electrode. The LFP is spectrally broad, and many researchers view this breadth as containing narrowband oscillatory components that may have distinct functional roles. This supported by observation phase oscillations often correlated with excitability relate to timing spiking fidelity sensory evoked responses. Accordingly, commonly tune these channels filtering LFP. Alternatively, neural fundamentally broadband composed transient, nonstationary rhythms are difficult approximate oscillations. In view, instantaneous state broad ensemble relates directly no particular allegiance any frequency band. To test between alternatives, we asked whether neocortical marmoset either sex better aligned within narrow bands or measure. We find provides predictor spike than after bands. results challenge neocortex system oscillators supports intrinsically broadband. SIGNIFICANCE STATEMENT Research into dynamical populations attributes unique significance components. However, spectrum. captured over latent component. suggest interpretations limited, broader representations provide higher describing moment-to-moment

Language: Английский

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Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 5, 2022

Abstract Life-long brain function and mental health are critically determined by developmental processes occurring before birth. During mammalian pregnancy, maternal cells transferred to the fetus. They referred as microchimeric (MMc). Among other organs, MMc seed into fetal brain, where their is unknown. Here, we show that, in offspring’s developing mice, express a unique signature of sensome markers, control microglia homeostasis prevent excessive presynaptic elimination. Further, facilitate oscillatory entrainment prefrontal-hippocampal circuits support maturation behavioral abilities. Our findings highlight that not mere placental leak out, but rather functional mechanism shapes optimal conditions for healthy later life.

Language: Английский

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Early brain activity: Translations between bedside and laboratory

Progress in Neurobiology, Journal Year: 2022, Volume and Issue: 213, P. 102268 - 102268

Published: March 29, 2022

Language: Английский

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Tapered Fibers Combined With a Multi-Electrode Array for Optogenetics in Mouse Medial Prefrontal Cortex

Frontiers in Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: Oct. 26, 2018

Optogenetics offers many advantages in terms of cell-type specificity, allowing to investigate functional connectivity between different brain areas at high spatial and neural population selectivity. In order obtain simultaneous optical control electrical readout activity, devices called "optrodes" are employed. They typically composed a linear array microelectrodes integrated on slender probe shafts combined with flat-cleaved fibers (FF) placed above the recording sites. However, due tissue absorption scattering, light delivered by FF unevenly illuminates region interest. This issue is particular relevance when cellular populations disposed along dorso-ventral axis, such as medial prefrontal cortex (mPFC) where cortical layers aligned vertically. The study presented here aims using tapered (TFs) combination 16-electrode better access distributed axis mPFC newborn mice, restricting delivery over specific portion layer Half TF surface coated reflecting metal blocking enable from one side probe's shaft only, base being designed host fiber without interfering wire-bonds that connect sites printed circuit board. Monte-Carlo simulations have been implemented define relative TF-probe position identify intensity distribution vivo recordings indicate stimulation activity benefit use engineered TF-based optrode more uniform possibility subset

Language: Английский

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Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse

eLife, Journal Year: 2018, Volume and Issue: 7

Published: April 10, 2018

The long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. discontinuous hippocampal theta bursts have been proposed to drive the generation of neonatal prefrontal oscillations, yet cellular substrate these interactions is still unresolved. Here, we selectively target optogenetic manipulation glutamatergic projection neurons CA1 area either dorsal or intermediate/ventral hippocampus at age elucidate their contribution emergence oscillatory entrainment. We show despite stronger and ripples power hippocampus, cortex mainly coupled with by phase-locking neuronal firing via dense direct axonal projections. Theta band-confined activation light pyramidal but not were transfected utero electroporation high-efficiency channelrhodopsin boosts oscillations. Our data causally origin developing brain.

Language: Английский

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