ACS Macro Letters,
Journal Year:
2019,
Volume and Issue:
8(11), P. 1522 - 1527
Published: Nov. 1, 2019
Sonication
of
gallium
or
gallium-based
liquid
metals
in
an
aqueous
solution
vinyl
monomers
leads
to
rapid
free
radical
polymerization
(FRP),
without
the
need
for
conventional
molecular
initiators.
Under
ambient
conditions,
a
passivating
native
oxide
separates
these
from
and
renders
metal
effectively
inert.
However,
sonication
generates
nanoparticles
(LMNPs)
∼100
nm
diameter
thereby
increases
surface
area
metal.
The
exposed
initiates
polymerization,
which
proceeds
via
FRP
mechanism
yields
high
weight
polymers
that
can
form
physical
gels.
Spin
trapping
EPR
reveals
generation
radicals.
Time-of-flight
secondary
ion
mass
spectrometry
measurements
confirm
direct
polymer
bonding
gallium,
verifying
formation
surface-anchored
grafts.
grafted
modify
interfacial
properties,
is,
preference
particles
disperse
versus
organic
phases.
also
be
degrafted
isolated
using
strong
acid
base.
concept
physically
disrupting
passivated
surfaces
offers
new
routes
surface-initiated
has
implications
modification,
reduction
reactions,
fabrication
mechanically
responsive
materials.
Journal of the American Chemical Society,
Journal Year:
2019,
Volume and Issue:
141(34), P. 13572 - 13581
Published: Aug. 1, 2019
Cancer
treatments
are
confounded
by
severe
toxic
effects
toward
patients.
To
address
these
issues,
activatable
nanoprobes
have
been
designed
for
specific
imaging
and
destruction
of
cancer
cells
under
the
stimulation
cancer-associated
biomarkers.
Most
were
usually
activated
some
single-factor
stimulation,
but
this
restricts
therapeutic
specificity
between
diseased
normal
tissue;
therefore,
multifactor
activation
is
highly
desired.
end,
we
herein
develop
a
novel
dual-stimuli
responsive
theranostic
nanoprobe
simultaneously
photothermal
therapy
coactivation
"dual-key"
"nitric
oxide
(NO)/acidity",
so
as
to
further
improve
specificity.
Specifically,
integrated
weak
electron
acceptor
(benzo[c][1,2,5]thiadiazole-5,6-diamine)
into
donor−π-acceptor−π-donor
type
chromophore.
When
was
oxidized
NO
in
acidic
conditions
form
stronger
(5H-[1,2,3]triazolo[4,5-f]-2,1,3-benzothiadiazole),
molecule
absorption
significantly
increased
near-infrared
region,
based
on
intramolecular
charge
transfer
(ICT)
mechanism.
Under
dual-key
NO/acidity
within
tumor
associated
with
inflammation,
can
correspondingly
output
dual
signals
ratiometric
photoacoustic
vivo
do
enhanced
accuracy
Our
exhibited
higher
signal
enhancement
dual-factor
at
9.8
times
that
132
acidity
alone,
respectively.
Moreover,
through
such
NO/acidity,
produces
more
differentiation
hyperthermia
tissues,
afford
satisfactory
minimal
side
effects.
Thus,
our
work
presents
promising
strategy
improving
precision
therapy.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
31(33)
Published: June 14, 2019
Abstract
Photoregulation,
which
utilizes
light
to
remotely
control
biological
events,
provides
a
precise
way
decipher
biology
and
innovate
in
medicine;
however,
its
potential
is
limited
by
the
shallow
tissue
penetration
and/or
phototoxicity
of
ultraviolet
(UV)/visible
that
are
required
match
optical
responses
endogenous
photosensitive
substances.
Thereby,
biologically
friendly
near‐infrared
(NIR)
with
improved
desired
for
photoregulation.
Since
there
few
biomolecules
absorbing
or
emitting
NIR
region,
development
molecular
transducers
essential
convert
into
cues
regulation
events.
In
this
regard,
nanomaterials
able
UV/visible
light,
heat,
free
radicals
suitable
task.
Here,
recent
developments
nanotransducers
NIR‐light‐mediated
photoregulation
medicine
summarized.
The
emerging
applications,
including
neural
activity,
gene
expression,
visual
systems,
as
well
photochemical
bonding,
highlighted,
along
design
principles
nanotransducers.
Moreover,
current
challenges
perspectives
field
discussed.
ACS Macro Letters,
Journal Year:
2019,
Volume and Issue:
8(11), P. 1522 - 1527
Published: Nov. 1, 2019
Sonication
of
gallium
or
gallium-based
liquid
metals
in
an
aqueous
solution
vinyl
monomers
leads
to
rapid
free
radical
polymerization
(FRP),
without
the
need
for
conventional
molecular
initiators.
Under
ambient
conditions,
a
passivating
native
oxide
separates
these
from
and
renders
metal
effectively
inert.
However,
sonication
generates
nanoparticles
(LMNPs)
∼100
nm
diameter
thereby
increases
surface
area
metal.
The
exposed
initiates
polymerization,
which
proceeds
via
FRP
mechanism
yields
high
weight
polymers
that
can
form
physical
gels.
Spin
trapping
EPR
reveals
generation
radicals.
Time-of-flight
secondary
ion
mass
spectrometry
measurements
confirm
direct
polymer
bonding
gallium,
verifying
formation
surface-anchored
grafts.
grafted
modify
interfacial
properties,
is,
preference
particles
disperse
versus
organic
phases.
also
be
degrafted
isolated
using
strong
acid
base.
concept
physically
disrupting
passivated
surfaces
offers
new
routes
surface-initiated
has
implications
modification,
reduction
reactions,
fabrication
mechanically
responsive
materials.
