Gathering brings strength: How organic aggregates boost disease phototheranostics

Aggregate, Journal Year: 2021, Volume and Issue: 2(1), P. 95 - 113

Published: Jan. 22, 2021

Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially rationally utilize energy dissipation pathways Jablonski diagram to modulate fluorescence emission, photoacoustic/photothermal production, photodynamic processes. Of particular interest are systems exhibiting huge differences aggregate state as compared with solution or single molecule form, during intramolecular motions play an important role regulating properties. The advances from such aspect biomedical applications including high‐resolution imaging, activatable imaging therapy, adaptive theranostics, image‐guided surgery, immunotherapy, afterglow discussed. A brief summary perspective this field also presented. We hope will be helpful researchers interested bioprobe design theranostic inspire new insights into linkage between science field.

Language: Английский

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Design, Synthesis, and Application of a Small Molecular NIR-II Fluorophore with Maximal Emission beyond 1200 nm

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(36), P. 15271 - 15275

Published: Aug. 21, 2020

Small molecular fluorophores in the second near-infrared window (NIR-II) have aroused much interest because of their excellent performance. Herein, a new small NIR-II fluorophore, FM1210, with maximal emission beyond 1200 nm is reported. Compared to corresponding control fluorophore CF1065, FM1210 exhibits an increase 145 maximum, which ascribed simultaneous introduction both Se atom and amino groups into benzo[1,2-c:4,5-c′]bis([1,2,5]thiadiazole) skeleton. This large enables be capable vivo imaging lower autofluorescence, higher signal-to-background ratio, better resolution. Moreover, nanosized encapsulated liposomes possesses passive targeting ability good water solubility, suitable for tumor even its vasculature high ratio.

Language: Английский

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An Acidity‐Unlocked Magnetic Nanoplatform Enables Self‐Boosting ROS Generation through Upregulation of Lactate for Imaging‐Guided Highly Specific Chemodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(17), P. 9562 - 9572

Published: Feb. 16, 2021

Chemodynamic therapy is an emerging tumor therapeutic strategy. However, the anticancer effects are greatly limited by strong acidity requirements for effective Fenton-like reaction, and inevitably "off-target" toxicity. Herein, we develop acidity-unlocked nanoplatform (FePt@FeOx@TAM-PEG) that can accurately perform high-efficient tumor-specific catalysis treatment, through dual pathway of cyclic amplification Notably, pH-responsive peculiarity tamoxifen (TAM) drug allows catalytic activity FePt@FeOx to be "turn-on" in acidic microenvironments, while keeping silence neutral condition. Importantly, released TAM within cancer cells able inhibit mitochondrial complex I, leading upregulated lactate content thereby accumulated intracellular H+, which overcome intrinsically insufficient tumor. Through positive feedback loop, large amount active nanocatalyzers access endogenous H2O2, exerting improved reaction more Finally, such smart enables self-boosting generation reactive oxygen species (ROS) induces oxidative stress, substantial outcomes vivo, may provide a new insight cascade reducing toxicity surrounding normal tissues.

Language: Английский

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Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 6850 - 6918

Published: March 2, 2022

Photoacoustic (PA) imaging technology, a three-dimensional hybrid modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular due to its high depth resolution. To endow PA with ability for real-time visualization precise biomedical diagnosis, numerous activatable probes which can specifically alter their intensities upon reacting targets or biological events interest have been developed. This review highlights recent developments applications including detection biotargets events. First, generation mechanism signals will be given, followed by brief introduction contrast agents used probe design. Then we particularly summarize general design principles alteration strategies developing probes. Furthermore, give detailed discussion living systems. At last, current challenges outlooks future discussed. We hope this stimulate new ideas explore potentials future.

Language: Английский

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Recent advances in the development of NIR-II organic emitters for biomedicine

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 415, P. 213318 - 213318

Published: April 9, 2020

Language: Английский

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Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 427, P. 213556 - 213556

Published: Sept. 16, 2020

Language: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

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Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

The Innovation, Journal Year: 2021, Volume and Issue: 2(1), P. 100082 - 100082

Published: Jan. 19, 2021

Phototheranostics integrates deep-tissue imaging with phototherapy (containing photothermal therapy and photodynamic therapy), holding great promise in early diagnosis precision treatment of cancers. Recently, second near-infrared (NIR-II) fluorescence exhibits the merits high accuracy specificity, as well real-time detection. Among NIR-II fluorophores, organic small molecular fluorophores have shown superior properties biocompatibility, variable structure, tunable emission wavelength than inorganic materials. What's more, some also display excellent cytotoxicity when illuminated NIR laser. This review summarizes progress different central cores for cancer phototheranostics past few years, focusing on structures phototheranostic performances. Furthermore, challenges prospects future development toward clinical translation are discussed.

Language: Английский

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A General Approach to Design Dual Ratiometric Fluorescent and Photoacoustic Probes for Quantitatively Visualizing Tumor Hypoxia Levels In Vivo

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(7)

Published: July 6, 2021

Abstract Herein, we describe an energy balance strategy between fluorescence and photoacoustic effects by sulfur substitution to transform existing hemicyanine dyes (Cy) into optimized NIRF/PA dual ratiometric scaffolds. Based on this scaffold, reported the first dual‐ratio response of nitroreductase probe AS‐Cy‐NO 2 , which allows quantitative visualization tumor hypoxia in vivo. composed a new scaffold thioxanthene‐hemicyanine (AS‐Cy‐1) 4‐nitrobenzene moiety, showed 10‐fold NIRF enhancement (I 773 /I 733 ) 2.4‐fold PA (PA 730 /PA 670 upon activation biomarker (nitroreductase, NTR) associated with hypoxia. Moreover, imaging accurately quantified extent high sensitivity depth xenograft breast cancer models. More importantly, 3D maximal intensity projection (MIP) images can precisely differentiate highly heterogeneous oxygen distribution solid tumor. Thus, study provides promising that may be generalized for other disease‐relevant biomarkers.

Language: Английский

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Mitochondria‐Targeting Phototheranostics by Aggregation‐Induced NIR‐II Emission Luminogens: Modulating Intramolecular Motion by Electron Acceptor Engineering for Multi‐Modal Synergistic Therapy

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(16)

Published: Jan. 10, 2022

Abstract Phototheranostic agents have thrived as promising tools for cancer theranostics because of the integration sensitive in situ fluorescence imaging and effective multi‐model synergistic therapy. However, how to manipulate intangible photon energy transfer balance competitive radiative nonradiative processes is still challenging. Although numerous phototheranostic molecules are reported, their complicated molecular design tedious synthesis often stumble further development. Herein, three simple with electron donating−accepting structures developed. The acceptor engineering on by introducing acridinium unit gives rise TPEDCAc aggregation‐induced second near‐infrared emission (AIE NIR‐II), high reactive oxygen species generation capability, excellent photothermal conversion efficiency (44.8%) due drastic intramolecular motion large rotor balanced AIE effect. Experimental analysis calculation controlled suggested that torsional angle strong electron‐withdrawing ability keys NIR‐II photodynamic/photothermal conversion. Impressively, positively charged shows mitochondria‐targeting capability performance vivo multi‐modal under NIR laser irradiation. Hence, this work not only provides a single AIE‐based theranostic system but inspires new insights into future development platforms.

Language: Английский

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