Radiotherapy induces responses of lung cancer to CTLA-4 blockade

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(12), P. 1845 - 1851

Published: Oct. 24, 2018

Language: Английский

---

Harnessing innate immunity in cancer therapy

Nature, Journal Year: 2019, Volume and Issue: 574(7776), P. 45 - 56

Published: Oct. 2, 2019

Language: Английский

---

Phagocytosis checkpoints as new targets for cancer immunotherapy

Nature reviews. Cancer, Journal Year: 2019, Volume and Issue: 19(10), P. 568 - 586

Published: Aug. 28, 2019

Language: Английский

---

Detection of immunogenic cell death and its relevance for cancer therapy

Cell Death and Disease, Journal Year: 2020, Volume and Issue: 11(11)

Published: Nov. 26, 2020

Abstract Chemotherapy, radiation therapy, as well targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely on the antigenicity of malignant cells and their capacity to generate adjuvant signals. In particular, immunogenic cell death (ICD) is accompanied by exposure release numerous damage-associated molecular patterns (DAMPs), altogether confer a robust adjuvanticity dying cancer cells, they favor recruitment activation antigen-presenting cells. ICD-associated DAMPs include surface-exposed calreticulin (CALR) secreted ATP, annexin A1 (ANXA1), type I interferon, high-mobility group box 1 (HMGB1). Additional hallmarks ICD encompass phosphorylation eukaryotic translation initiation factor 2 subunit-α (EIF2S1, better known eIF2α), autophagy, global arrest in transcription translation. Here, we outline methodological approaches for measuring markers vitro ex vivo discovery next-generation antineoplastic agents, development personalized regimens, identification optimal therapeutic combinations clinical management cancer.

Language: Английский

---

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(6), P. 920 - 928

Published: May 13, 2019

Language: Английский

---

Enhancing cancer immunotherapy with nanomedicine

Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 20(5), P. 321 - 334

Published: Jan. 31, 2020

Language: Английский

---

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(1), P. 152 - 164

Published: Jan. 1, 2021

Language: Английский

---

Radiotherapy toxicity

Nature Reviews Disease Primers, Journal Year: 2019, Volume and Issue: 5(1)

Published: Feb. 21, 2019

Language: Английский

---

Control of Metastasis by NK Cells

Cancer Cell, Journal Year: 2017, Volume and Issue: 32(2), P. 135 - 154

Published: Aug. 1, 2017

Language: Английский

---

Inflammatory microenvironment remodelling by tumour cells after radiotherapy

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(4), P. 203 - 217

Published: March 11, 2020

Language: Английский

---