Nanoparticle‐Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(10)

Published: Jan. 21, 2019

External radiotherapy is extensively used in clinic to destruct tumors by locally applied ionizing-radiation beams. However, the efficacy of usually limited tumor hypoxia-associated radiation resistance. Moreover, as a local treatment technique, can hardly control metastases, major cause cancer death. Herein, core-shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, encapsulating water-soluble catalase (Cat), an enzyme that decompose H2 O2 generate , inside inner core, and loading hydrophobic imiquimod (R837), Toll-like-receptor-7 agonist, within PLGA shell. The formed PLGA-R837@Cat greatly enhance relieving hypoxia modulating immune-suppressive microenvironment. tumor-associated antigens generated postradiotherapy-induced immunogenic cell death presence such R837-loaded adjuvant will induce strong antitumor immune responses, which together with cytotoxic T-lymphocyte associated protein 4 (CTLA-4) checkpoint blockade be able effectively inhibit metastases abscopal effect. long term immunological memory effect protect mice from rechallenging observed post treatment. This work thus presents unique nanomedicine approach next-generation strategy enable synergistic whole-body therapeutic responses after treatment, promising for clinical translation.

Language: Английский

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The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

Cell, Journal Year: 2018, Volume and Issue: 174(6), P. 1347 - 1360

Published: Sept. 1, 2018

Language: Английский

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Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(4), P. 251 - 266

Published: Feb. 7, 2020

Language: Английский

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Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies

Immunity, Journal Year: 2018, Volume and Issue: 48(3), P. 417 - 433

Published: March 1, 2018

Language: Английский

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The hallmarks of successful anticancer immunotherapy

Science Translational Medicine, Journal Year: 2018, Volume and Issue: 10(459)

Published: Sept. 19, 2018

Various features of the tumor and immune system influence success immunotherapy.

Language: Английский

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